Biochemical and Clinical Aspects of Neuropeptides Synthesis, Processing, and Gene Structure

Biochemical and Clinical Aspects of Neuropeptides Synthesis, Processing, and Gene Structure

1st Edition - January 1, 1983

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  • Editor: Gebhard Koch
  • eBook ISBN: 9780323155595

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Biochemical and Clinical Aspects of Neuropeptides: Synthesis, Processing, and Gene Structure covers the proceedings of the Fifth Conference on Macromolecular Synthesis: Biochemical and Clinical Aspects of Neuropeptides, held in Blankenese, Hamburg, Germany. This book is composed of seven parts encompassing 23 chapters, and begins with an introduction of the proteolytic mechanisms involved in proprotein processing, their intracellular localization, and their roles in generating a diverse assortment of secreted products in a variety of neuroendocrine cells. Part I describes the structure, synthesis, biochemical aspects, gene expression, and receptor selectivity of opioid peptides. Parts II and III focus on the isolation, structure, function, and genetic linkage of neuropeptides. The remaining parts explore the posttranslational processing, regulation, metabolism, biosynthesis, and gene expression of these neuropeptides, with a particular emphasis on their triggering mechanism and the control of release. Biochemists, neurologists, geneticists, and clinicians will greatly appreciate this book.

Table of Contents

  • Contributors



    Intracellular Proteolytic Mechanisms in the Biosynthesis of Hormones and Peptide Neurotransmitters

    Part I: Opioid Peptides

    Human s-Lipotropin

    Biochemical Studies and Proenkephalin and the Products Derived from its Processing

    Expression of the Opioid Genes

    Receptor Selectivities of the Three Opioid Peptide Families

    Part II: Novel Neuropeptides

    Structure and Function of a New Neuropeptide, the Head Activator, Controlling Head Formation in Hydra

    Isolation and NH2-Terminal Sequence of a Highly Conserved Pituitary and Hypothalamic Protein Belonging to a New Superfamily

    Part III: Neuropeptide Deficiencies

    Multiple Forms of Neuropeptides in Human CSF and their Significance

    Genetic Linkage Analysis in Familial Dysautonomia Using a DNA Probe for the s-Nerve Growth Factor Gene

    Correction of Genetic GnRH (Gonadotropin-Releasing Hormone) Deficiency in the Mouse by Preoptic Area Transplants

    Part IV: Posttranslational Processing

    Posttranslational Processing of Gastrin/CCK Peptides in the Central Nervous System

    Processing in Nerves and Endocrine Cells of Peptides Related to FMRFamide and Met-Enkephalin Arg6Phe7

    Biosynthesis of Peptides in Amphibian Skin

    Processing Signals of the Vasopressin and Oxytocin Precursors

    Part V: Regulation and Metabolites

    Degradation of Neuropeptides

    Metabolites of Arginine-Vasopressin and Oxytocin Are Highly Potent Neuropeptides in the Brain

    Part VI: Structure and Biosynthesis of Releasing Factors

    Characterization of Rat Hypothalamic Growth Hormone and Corticotropin Releasing Factors

    Purification Studies on Putative LHRH Precursors

    Tentative Identification of Luteinizing Hormone Release Hormone (LHRH)-Like Immunoreactivity among in Vitro Translation Products of Hypothalamic mRNA

    Part VII: Expression of Neuropeptide Genes

    Partial Sequence of the Rat Oxytocin Gene

    Regulation of Growth Hormone Gene Expression

    Epidermal Growth Factor mRNA Codes for a Potential Polyprotein Precursor

    Structure of Precursors Derived from the Sequences of Cloned cDNAs


Product details

  • No. of pages: 330
  • Language: English
  • Copyright: © Academic Press 1983
  • Published: January 1, 1983
  • Imprint: Academic Press
  • eBook ISBN: 9780323155595

About the Editor

Gebhard Koch

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