Biochemical Actions of Hormones V8

Biochemical Actions of Hormones V8

1st Edition - January 28, 1981

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  • Editor: Gerald Litwack
  • eBook ISBN: 9780323146135

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Biochemical Actions of Hormones, Volume VIII is an eight-chapter text that covers the developments in the understanding of the biochemical aspects of hormonal action and regulation. This volume examines first the messenger functions of calcium in hormonal systems. The next chapters deal with the neuronal regulation of blood pressure; the regulation of protein synthesis by phosphorylation; and the hormonal control of hepatic gluconeogenesis. These topics are followed by discussions on the effects of insulin in intracellular functions, the mechanisms of steroidal hormones, and the membrane recognition and effector sites in steroid hormone action. A chapter focuses on the activation of steroid-receptor complexes. The final chapters survey the estradiol and progesterone receptors in the human endometrium. This book will be of great value to biologists, biochemists, and researchers in the field of hormonal action.

Table of Contents

  • List of Contributors


    1. The Messenger Function of Calcium in Endocrine Systems

    I. Introduction

    II. Historical Perspective

    III. Cellular Calcium Metabolism

    IV. Stimulus-Response Coupling

    V. Interrelationships between Calcium and Cyclic Nucleotides in Stimulus-Response Coupling

    VI. Calcium as Messenger in Specific Systems

    VII. Conclusions


    2. Neuronal Regulation of Blood Pressure

    I. Organization of Central Nervous System Areas Regulating Blood Pressure

    II. Peripheral Regulation

    III. Central Nervous System Regulation

    IV. Conclusion


    3. Regulation of Protein Synthesis by Prosphorylation

    I. Introduction

    II. Ribosomes

    III. Initiation Factors

    IV. Hemin Regulation of Protein Synthesis

    V. Interferon and Double-Stranded RNA Activated Inhibition of Protein Synthesis

    VI. Aminoacyl-tRNA Synthetases

    VII. Conclusions


    4. Hormonal Control of Hepatic Gluconeogenesis

    I. Introduction

    II. Role of Cyclic AMP in Hormonal Control of Gluconeogenesis

    III. Sites of Action of Hormones on Hepatic Gluconeogenesis

    IV. Summary

    V. Overview


    5. Effects of Insulin on Intracellular Functions

    I. Introduction

    II. Intracellular Effects of Insulin

    III. Mechanism of Insulin Action

    IV. Cellular Binding Sites for Insulin

    V. The Entry of Insulin into Target Cells

    VI. Hypothesis, Speculation, and Conclusion


    6. Membrane Recognition and Effector Sites in Steroid Hormone Action

    I. Introduction

    II. Compartmentation in the Cellular Economy

    III. Cell Surface Specialization and the Occurrence of Recognition Systems

    IV. The Cell Surface: Alterations of Membrane Architecture on Binding Site Occupancy

    V. Dynamics of Cell Surface Recognition Sites: Molecular and Cellular Aspects

    VI. Evaluation of Current Models of Steroid Hormone Accumulation and Distribution in Target Cells

    VII. Closing Comments


    7. Activation of Steroid-Receptor Complexes

    I. Introduction

    II. Methods of Studying Activation

    III. The Mechanism of Activation

    IV. Factors Effecting the Activation Reaction

    V. Reversal from the Activated to the Nonactivated State (Deactivation)

    VI. Use of Activation to Purify the Receptor

    VII. Conclusions


    8. Estradiol and Progesterone Receptors in Human Endometrium

    I. Introduction

    II. Methodological Problems

    III. Estradiol and Progesterone Receptors in the Normal Menstrual Cycle

    IV. General Conclusions



    Contents of Previous Volumes

Product details

  • No. of pages: 558
  • Language: English
  • Copyright: © Academic Press 1981
  • Published: January 28, 1981
  • Imprint: Academic Press
  • eBook ISBN: 9780323146135

About the Editor

Gerald Litwack

Dr. Litwack is an accomplished and prolific author and editor at Elsevier. Spanning over 25 years, he has been the editor of over 55 volumes of Vitamins and Hormones, co-author of Hormones, editor of 14 volumes of Biochemical Actions of Hormones, co-editor of Actions of Hormones on Molecular Processes, author of Human Biochemistry and Disease, and just wrapping up Human Biochemistry. He also authored Experimental Biochemistry [Wiley] and edited Receptor Purification, 2 volumes [Humana]. He is an author on over 300 journal articles and has been on the editorial boards of numerous journals, including Endocrinology, Oncology Research, Oncology Reports, Journal of Molecular Biochemistry, Chemtracts, Cancer Research, Apoptosis, and Critical Reviews in Eukaryotic Gene Expression.

Affiliations and Expertise

Emeritus Professor and Chair of Basic Sciences, Geisinger Commonwealth School of Medicine, Scranton, PA, USA

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