Biochemical Actions of Hormones V6

Biochemical Actions of Hormones V6

1st Edition - January 28, 1979

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  • Editor: Gerald Litwack
  • eBook ISBN: 9780323146388

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Biochemical Actions of Hormones, Volume VI is a 10-chapter text that summarizes the regulation of protein kinases and phosphoprotein phosphatases and the relationship of the endocrines to cancer. This volume describes first the precise structures of steroid hormones and carcinogens. The subsequent chapters cover the hormonal regulation of chemical carcinogenesis; the importance of steroid hormones as growth factors for mammary tumors; the effects of steroid hormones in the central nervous system; and the properties of the purified estrogen receptor. A chapter highlights the biochemical actions of neurohypophysial hormones and neurophysin. Another chapter presents the biochemistry and physiology of cytokinin, a plant hormone. The final chapter exemplifies the multihormonal systems by control of the α2u-globulin produced in the liver. This book will be of great value to endocrinologists.

Table of Contents

  • List of Contributors


    Contents of Previous Volumes

    1. The Physiological Regulation and Function of cAMP-Dependent Protein Kinases

    I. Introduction

    II. Properties of the cAMP-Dependent Protein Kinase

    III. Approaches for Evaluating the Function of cAMP-Dependent Protein Kinase: In Vitro and In Vivo Criteria

    IV. Specific Systems



    2. Hormonal and Metabolic Control of Phosphoprotein Phosphatase

    I. Introduction

    II. Enzyme Properties

    III. Hormonal Control

    IV. Conclusions


    3. Structural Aspects of Steroid Hormones and Carcinogenic Polycyclic Aromatic Hydrocarbons

    I. Structures of Steroids

    II. Biochemical Mechanisms Involving Steroids That Have Been Studied by Crystallographic Techniques

    III. Carcinogenic Polycyclic Aromatic Hydrocarbons and Their Structural Similarities to Steroids

    IV. Summary



    4. Modulation of Chemical Carcinogenesis by Hormones

    I. Introduction

    II. Mammary Gland

    III. Ovary

    IV. Liver

    V. Relationship of Binding Proteins (Enzymes) and Carcinogenesis

    VI. Conclusions



    5. How Important Are Steroids in Regulating the Growth of Mammary Tumors?

    I. General Comments on Mammary Tumor Growth

    II. Growth Characteristics of Human Breast Tumors

    III. Regulation of Cell Proliferation

    IV. Cell Loss

    V. Blood Supply

    VI. Cell-Cell Interaction

    VII. Immune Response to Breast Tumors

    VIII. Conclusions


    6. Biochemical Actions of Neurohypophysial Hormones and Neurophysin

    I. Introduction: Physiological Actions of Neurohypophysial Hormones

    II. Neurophysins

    III. Neurohypophysial Hormone-Receptor Interactions

    IV. Neurohypophysial Hormone Stimulus Generation

    V. Relationship between Stimulus Generation and Response

    VI. Molecular Events Mediating Neurohypophysial Hormone Action

    VII. Concluding Comments


    7. Biochemistry and Physiology of Cytokinins

    I. Introduction

    II. Effects of Physiological Processes

    III. Chemistry and Structure-Activity Relationships

    IV. Metabolism of Cytokinins

    V. Cytokinins in Nucleic Acids

    VI. Effects of Cytokinins on Metabolism

    VII. Concluding Remarks


    8. Steroid Hormone Receptors in the Central Nervous System

    I. Introduction

    II. Technical Aspects of Measuring Steroid Binding to Putative Receptors in Brain and Pituitary

    III. Neural and Pituitary Steroid Receptors in Relation to Function

    IV. Concluding Remarks


    9. Properties of Estrogen Receptor Purified to Homogeneity

    I. Introduction

    II. Purification to Homogeneity Estrogen Receptor

    III. Properties of Estrogen Receptor Purified to Homogeneity

    IV. Final Remarks and Conclusions


    10. Hormonal Regulation of α2u Globulin in Rat Liver

    I. Introduction

    II. Androgen-Dependent Synthesis of α2u Globulin and Its Modulation by Other Hormonal and Developmental Factors

    III. Cytoplasmic Androgen Binding Protein of Rat Liver and Its Possible Role in the Regulation of α2u Globulin

    IV. Messenger RNA for α2u Globulin and Its Regulation by Various Hormones

    V. Concluding Remarks



Product details

  • No. of pages: 548
  • Language: English
  • Copyright: © Academic Press 1979
  • Published: January 28, 1979
  • Imprint: Academic Press
  • eBook ISBN: 9780323146388

About the Editor

Gerald Litwack

Dr. Litwack is an accomplished and prolific author and editor at Elsevier. Spanning over 25 years, he has been the editor of over 55 volumes of Vitamins and Hormones, co-author of Hormones, editor of 14 volumes of Biochemical Actions of Hormones, co-editor of Actions of Hormones on Molecular Processes, author of Human Biochemistry and Disease, and just wrapping up Human Biochemistry. He also authored Experimental Biochemistry [Wiley] and edited Receptor Purification, 2 volumes [Humana]. He is an author on over 300 journal articles and has been on the editorial boards of numerous journals, including Endocrinology, Oncology Research, Oncology Reports, Journal of Molecular Biochemistry, Chemtracts, Cancer Research, Apoptosis, and Critical Reviews in Eukaryotic Gene Expression.

Affiliations and Expertise

Emeritus Professor and Chair of Basic Sciences, Geisinger Commonwealth School of Medicine, Scranton, PA, USA

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