Biochemical Actions of Hormones V5 - 1st Edition - ISBN: 9780124528055, 9780323148719

Biochemical Actions of Hormones V5

1st Edition

Editors: Gerald Litwack
eBook ISBN: 9780323148719
Imprint: Academic Press
Published Date: 28th January 1978
Page Count: 482
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Biochemical Actions of Hormones, Volume V explores the nature of interaction of multiple hormones in regulating specific phenotypes. This volume is organized into 11 chapters that include discussions on the developments in the understanding of the biochemistry and molecular biology of hormones. The opening chapters deal with the modifications of chromatin structure by hormones, the regulation of exocytosis, ontogeny of estrogen receptors, and the hormonal regulation of cells of the seminiferous tubule. The discussions then shift to the advances on the progesterone receptor, the role of glucocorticoids in the integration of mammary tumor virus genes, and a model system for estrogen action. Other chapters examine the physiology, molecular action, and biological effects of somatomedins, epidermal growth factors and 1,25-dihydroxyvitamin. The remaining chapters focus on multihormone control of mRNA for a specific hepatic protein. This book is of great value to endocrinologists.

Table of Contents

List of Contributors


Contents of Previous Volumes

1. Postsynthetic Modifications of Histone Primary Structure: Phosphorylation and Acetylation as Related to Chromatin Conformation and Function

I. Introduction

II. Histone Phosphoryfotion

III. Histone Acetylation

IV. Histone Modifications and Chromatin Structure


2. Regulation of Exocytosis

I. Introduction

II. Steps in the Secretory Process

III. Possible Mechanisms of Cell Membrane Fusion

IV. Sites of Fusion between Plasma and Secretory Granule Membranes

V. An Electrostatic Function for Calcium in Exocytosis

VI. Coupling of Endocytosis with Exocytosis

VII. Release of Secretory Granule Contents in a Cell-Free System

VIII. The Role of Calcium in Secretory Processes

IX. Microtubules and Contractile Proteins

X. Abnormalities in Exocytosis

XI. Sulfhydryl Groups and Secretory Processes

XII. A Possible Mechanism for the Regulatory Role of Calcium in Exocytosis

XIII. Summary


3. The Somatomedins and Their Actions

I. Introduction

II. History of the Somatomedins

III. Isolation and Chemistry of the Somatomedins

IV. Origin and Degradation of the Somatomedins

V. In Vitro Biological Effects of the Somatomedins

VI. Interactions of the Somatomedins with Specific Somatomedin Receptors

VII Physiological Regulation of the Somatomedins

VIII. Concluding Remarks


4. The Ontogeny of Estrogen Receptors

I. Introduction

II. Mammalian Reproductive Tract

III. The Mammalian Neuroendocrine System

IV. Mammalian Visceral Organs

V. The Chick Embryo

VI. Concluding Remarks


5. Epidermal Growth Factors

I. Introduction

II. Isolation of Epidermal Growth Factors

III. Chemical and Physical Properties of EGF

IV. Control of EGF Levels and Secretion in the Submaxillary Gland of the Mouse

V. Biological Activity of EGF In Vivo

VI. Biological Activity of EGF in Organ Culture

VII. Biological Activity of EGF in Cell Culture

VIII. Interaction of 125I-Labeled EGF with Biological Material

IX. Epilogue


6. Sites of Action of Androgens and Follicle Stimulating Hormone on Cells of the Seminiferous Tubule

I. Introduction and Perspectives

II. Evidence that Androgen Influences on Spermatogenesis are Mediated via Direct Effects on Testicular Somatic Cells and Not on Germinal Cells

III. Responses of Testicular Somatic Cells in the Seminiferous Tubule to Androgens and FSH

IV. Speculations on Mechanisms by Which Testicular Somatic Cells May Influence Germinal Cell Development


7. Biochemical Properties of the Intestinal Receptor System for the Steroid Hormone 1,25-Dihydroxyvitamin D

I. Introduction

II. Biochemical Properties of Intestinal Receptor System

III. Structure-Function Studies


8. The Chick Oviduct Progesterone Receptor

I. Introduction

II. Oviduct Progesterone Receptor-Hormone Interactions

III. Enzymatic and Binding Activities of the Chick Oviduct Progesterone Receptor

IV. Progesterone Receptor Forms

V. Characteristics of Receptor Aggregate Forms

VI. Progesterone Receptor Interaction with Nuclear Components

VII. Effects of the Chick Oviduct Progesterone Receptor on Transcription

VIII. Molecular Model of Steroid Hormone Action

IX. Future Directions


9. Integrated Mammary Tumor Virus Genes: Transcriptional Regulation by Glucocorticoids and Specific Effects on Host Gene Expression

I. Mammary Tumor Virus DNA as a Specific Genetic Probe

II. RNA Synthesis in Isolated GR Cell Nuclei

III. Responsiveness of MTV Genes in Infected HTC Cells

IV. Altered Host Gene Expression in Infected HTC Cells

V. MTV and Transposable Genetic Elements


10. Induction and Regulation of Vitellogenin Synthesis by Estrogen

I. Introduction

II. Vitellogenin

III. Physiology of Vitellogenesis

IV. Protein Synthesis in the Liver during Vitellogenin Induction

V. Translational Control and Posttranslational Modifications of Vitellogenin

VI. Estradiol Receptors and the Expression of the Vitellogenin Gene


11. Multihormonal Control of the Messenger RNA for the Hepatic Protein Globulin

I. Introduction

II. α2U Globulin

III. Effect of Thyroid Hormones on α2u Globulin Synthesis and α2u Globulin mRNA

IV. Effects of Sex Hormones on α2u Globulin Synthesis and mRNA

V. Effects of Other Hormones on α2u Globulin Synthesis and mRNA

VI. α2u Globulin Synthesis in Isolated Hepatocyte Suspensions

VII. α2u Globulin Synthesis in Hepatomas

VIII. Conclusions




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© Academic Press 1978
Academic Press
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About the Editor

Gerald Litwack

Dr. Litwack is an accomplished and prolific author and editor at Elsevier. Spanning over 25 years, he has been the editor of over 55 volumes of Vitamins and Hormones, co-author of Hormones, editor of 14 volumes of Biochemical Actions of Hormones, co-editor of Actions of Hormones on Molecular Processes, author of Human Biochemistry and Disease, and just wrapping up Human Biochemistry. He also authored Experimental Biochemistry [Wiley] and edited Receptor Purification, 2 volumes [Humana]. He is an author on over 300 journal articles and has been on the editorial boards of numerous journals, including Endocrinology, Oncology Research, Oncology Reports, Journal of Molecular Biochemistry, Chemtracts, Cancer Research, Apoptosis, and Critical Reviews in Eukaryotic Gene Expression.

Affiliations and Expertise

, Emeritus Professor and Chair of Basic Sciences, Geisinger Commonwealth School of Medicine, Scranton, PA

Ratings and Reviews