Biochemical Actions of Hormones V5

Biochemical Actions of Hormones V5

1st Edition - January 28, 1978

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  • Editor: Gerald Litwack
  • eBook ISBN: 9780323148719

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Description

Biochemical Actions of Hormones, Volume V explores the nature of interaction of multiple hormones in regulating specific phenotypes. This volume is organized into 11 chapters that include discussions on the developments in the understanding of the biochemistry and molecular biology of hormones. The opening chapters deal with the modifications of chromatin structure by hormones, the regulation of exocytosis, ontogeny of estrogen receptors, and the hormonal regulation of cells of the seminiferous tubule. The discussions then shift to the advances on the progesterone receptor, the role of glucocorticoids in the integration of mammary tumor virus genes, and a model system for estrogen action. Other chapters examine the physiology, molecular action, and biological effects of somatomedins, epidermal growth factors and 1,25-dihydroxyvitamin. The remaining chapters focus on multihormone control of mRNA for a specific hepatic protein. This book is of great value to endocrinologists.

Table of Contents


  • List of Contributors

    Preface

    Contents of Previous Volumes

    1. Postsynthetic Modifications of Histone Primary Structure: Phosphorylation and Acetylation as Related to Chromatin Conformation and Function

    I. Introduction

    II. Histone Phosphoryfotion

    III. Histone Acetylation

    IV. Histone Modifications and Chromatin Structure

    References

    2. Regulation of Exocytosis

    I. Introduction

    II. Steps in the Secretory Process

    III. Possible Mechanisms of Cell Membrane Fusion

    IV. Sites of Fusion between Plasma and Secretory Granule Membranes

    V. An Electrostatic Function for Calcium in Exocytosis

    VI. Coupling of Endocytosis with Exocytosis

    VII. Release of Secretory Granule Contents in a Cell-Free System

    VIII. The Role of Calcium in Secretory Processes

    IX. Microtubules and Contractile Proteins

    X. Abnormalities in Exocytosis

    XI. Sulfhydryl Groups and Secretory Processes

    XII. A Possible Mechanism for the Regulatory Role of Calcium in Exocytosis

    XIII. Summary

    References

    3. The Somatomedins and Their Actions

    I. Introduction

    II. History of the Somatomedins

    III. Isolation and Chemistry of the Somatomedins

    IV. Origin and Degradation of the Somatomedins

    V. In Vitro Biological Effects of the Somatomedins

    VI. Interactions of the Somatomedins with Specific Somatomedin Receptors

    VII Physiological Regulation of the Somatomedins

    VIII. Concluding Remarks

    References

    4. The Ontogeny of Estrogen Receptors

    I. Introduction

    II. Mammalian Reproductive Tract

    III. The Mammalian Neuroendocrine System

    IV. Mammalian Visceral Organs

    V. The Chick Embryo

    VI. Concluding Remarks

    References

    5. Epidermal Growth Factors

    I. Introduction

    II. Isolation of Epidermal Growth Factors

    III. Chemical and Physical Properties of EGF

    IV. Control of EGF Levels and Secretion in the Submaxillary Gland of the Mouse

    V. Biological Activity of EGF In Vivo

    VI. Biological Activity of EGF in Organ Culture

    VII. Biological Activity of EGF in Cell Culture

    VIII. Interaction of 125I-Labeled EGF with Biological Material

    IX. Epilogue

    References

    6. Sites of Action of Androgens and Follicle Stimulating Hormone on Cells of the Seminiferous Tubule

    I. Introduction and Perspectives

    II. Evidence that Androgen Influences on Spermatogenesis are Mediated via Direct Effects on Testicular Somatic Cells and Not on Germinal Cells

    III. Responses of Testicular Somatic Cells in the Seminiferous Tubule to Androgens and FSH

    IV. Speculations on Mechanisms by Which Testicular Somatic Cells May Influence Germinal Cell Development

    References

    7. Biochemical Properties of the Intestinal Receptor System for the Steroid Hormone 1,25-Dihydroxyvitamin D

    I. Introduction

    II. Biochemical Properties of Intestinal Receptor System

    III. Structure-Function Studies

    References

    8. The Chick Oviduct Progesterone Receptor

    I. Introduction

    II. Oviduct Progesterone Receptor-Hormone Interactions

    III. Enzymatic and Binding Activities of the Chick Oviduct Progesterone Receptor

    IV. Progesterone Receptor Forms

    V. Characteristics of Receptor Aggregate Forms

    VI. Progesterone Receptor Interaction with Nuclear Components

    VII. Effects of the Chick Oviduct Progesterone Receptor on Transcription

    VIII. Molecular Model of Steroid Hormone Action

    IX. Future Directions

    References

    9. Integrated Mammary Tumor Virus Genes: Transcriptional Regulation by Glucocorticoids and Specific Effects on Host Gene Expression

    I. Mammary Tumor Virus DNA as a Specific Genetic Probe

    II. RNA Synthesis in Isolated GR Cell Nuclei

    III. Responsiveness of MTV Genes in Infected HTC Cells

    IV. Altered Host Gene Expression in Infected HTC Cells

    V. MTV and Transposable Genetic Elements

    References

    10. Induction and Regulation of Vitellogenin Synthesis by Estrogen

    I. Introduction

    II. Vitellogenin

    III. Physiology of Vitellogenesis

    IV. Protein Synthesis in the Liver during Vitellogenin Induction

    V. Translational Control and Posttranslational Modifications of Vitellogenin

    VI. Estradiol Receptors and the Expression of the Vitellogenin Gene

    References

    11. Multihormonal Control of the Messenger RNA for the Hepatic Protein Globulin

    I. Introduction

    II. α2U Globulin

    III. Effect of Thyroid Hormones on α2u Globulin Synthesis and α2u Globulin mRNA

    IV. Effects of Sex Hormones on α2u Globulin Synthesis and mRNA

    V. Effects of Other Hormones on α2u Globulin Synthesis and mRNA

    VI. α2u Globulin Synthesis in Isolated Hepatocyte Suspensions

    VII. α2u Globulin Synthesis in Hepatomas

    VIII. Conclusions

    References

    Index

Product details

  • No. of pages: 482
  • Language: English
  • Copyright: © Academic Press 1978
  • Published: January 28, 1978
  • Imprint: Academic Press
  • eBook ISBN: 9780323148719

About the Editor

Gerald Litwack

Dr. Litwack is an accomplished and prolific author and editor at Elsevier. Spanning over 25 years, he has been the editor of over 55 volumes of Vitamins and Hormones, co-author of Hormones, editor of 14 volumes of Biochemical Actions of Hormones, co-editor of Actions of Hormones on Molecular Processes, author of Human Biochemistry and Disease, and just wrapping up Human Biochemistry. He also authored Experimental Biochemistry [Wiley] and edited Receptor Purification, 2 volumes [Humana]. He is an author on over 300 journal articles and has been on the editorial boards of numerous journals, including Endocrinology, Oncology Research, Oncology Reports, Journal of Molecular Biochemistry, Chemtracts, Cancer Research, Apoptosis, and Critical Reviews in Eukaryotic Gene Expression.

Affiliations and Expertise

Emeritus Professor and Chair of Basic Sciences, Geisinger Commonwealth School of Medicine, Scranton, PA, USA

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