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Biochemical Actions of Hormones V4 - 1st Edition - ISBN: 9780124528048, 9780323146326

Biochemical Actions of Hormones V4

1st Edition

Editor: Gerald Litwack
eBook ISBN: 9780323146326
Imprint: Academic Press
Published Date: 28th January 1977
Page Count: 550
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Biochemical Actions of Hormones, Volume IV explores the significant developments toward understanding the primary effects of hormones in cellular receptors at the molecular level. This volume is composed of nine chapters, and begins with a review of the developments in affinity labeling that relate principally to the determination of the mechanisms of hormone action. The following chapters examine the role of prostaglandins in ovarian function and the methods for measuring protein synthesis and degradation in the heart and skeletal muscle. These topics are followed by discussions on the regulation of cholesterol synthesis by individual hormones; the regulatory mechanisms modulating the responsiveness of pineal gland to ß-adrenergic receptor stimulation; and the unitary mechanism of thyrotropin-releasing hormone action in target cells. The remaining chapters cover the insulin binding and insulin receptors from a variety of tissues and diverse species. These chapters also look into the physiology, molecular action, and biological effects of androgens and cyclic adenosine monophosphate. This book will be of great benefit to endocrinologists.

Table of Contents

List of Contributors


Contents of Previous Volumes

Gordon M. Tomkins (1926-1975)

1. Affinity Labeling as a Technique in Determining Hormone Mechanisms

I. Introduction

II. Fundamental Considerations

III. Steroid Binding Sites

IV. Cyclic Nucleotides

V. Protein Hormones

VI. Other Hormonal Systems

VII. Invertebrate Hormones

VIII. Plant Hormones

IX. Conclusion


2. Mechanism of Prostaglandin Action in Endocrine Glands

I. Introduction

II. Prostaglandins in Ovarian Function


3. Regulation of Protein Synthesis and Degradation in Heart and Skeletal Muscle

I. Introduction

II. Measurements of the Rate of Protein Synthesis

III. Localization of the Effects of Metabolic and Hormonal Factors to Steps in the Synthetic Pathway

IV. Measurement of Protein Degradation and Factors Affecting the Rate

V. Nutritional Factors Regulating Protein Turnover

VI. Role of Insulin in the Regulation of Protein Turnover

VII. Concluding Remarks


4. Hormonal Regulation of Cholesterol Synthesis

I. Introduction

II. Pancreas

III. Pituitary

IV. Thyroid

V. Adrenals

VI. Regulation by an Interplay of Hormones

VII. Regulation via Feedback Repression

VIII. Regulation of the Level of Cholesterol

IX. Regulation in Relation to Cardiovascular Disease

X. Perspective


5. The ß-Adrenergic Receptor and the Regulation of Circadian Rhythms in the Pineal Gland

I. Biosynthesis of Melatonin

II. Circadian Rhythms in the Pineal Gland

III. Conclusion


6. Cell Culture Studies of Thyrotropin-Releasing Hormone Action

I. Introduction

II. GH Cells Produce Both Growth Hormone and Prolactin

III. Are Both Prolactin and Growth Hormone Produced by a Single Cell?

IV. Biological Responses of GH Cells to TRH

V. The TRH Receptor

VI. Unitary Hypothesis of TRH Action

VII. Spare TRH Receptors—Multiple TRH Receptors

VIII. Summary


7. The Insulin Receptor: Properties and Regulation

I. Introduction

II. Indirect Studies

III. Early Direct Studies

IV. Properties of the Insulin Receptor

V. Regulation of Insulin Bioactivity at the Receptor Level

VI. Summary and Conclusions


8. Molecular Actions of Androgens

I. Introduction

II. Evidence for Selective Androgen Retention in Target Tissue

III. Cellular Localization and Multiple Forms of Androgen Receptors

IV. Structural Recognition in Androgen-Receptor Interaction

V. Transformation and Nuclear Retention of Androgen-Receptor Complex

VI. Acceptor Molecules and Receptor-Nucleoprotein Interaction

VII. Differential Action of Androgens and Universality of Receptors

VIII. Some Biodynamic Aspects of Androgen Receptors

IX. Mode of Action of Antiandrogens

X. RNA Synthesis

XI. Protein Synthesis

XII. Concluding Remarks—Interaction of Metals and Nucleotides with Steroid Receptors


9. Actions of Cyclic AMP and Its Relationship to Transmitter Function in Nervous Tissue

I. Introduction

II. Metabolism of Cyclic AMP and Its Regulation

III. Cytochemical Localization of Cyclic AMP

IV. Actions of Cyclic AMP

V. Conclusions




No. of pages:
© Academic Press 1977
28th January 1977
Academic Press
eBook ISBN:

About the Editor

Gerald Litwack

Dr. Litwack is an accomplished and prolific author and editor at Elsevier. Spanning over 25 years, he has been the editor of over 55 volumes of Vitamins and Hormones, co-author of Hormones, editor of 14 volumes of Biochemical Actions of Hormones, co-editor of Actions of Hormones on Molecular Processes, author of Human Biochemistry and Disease, and just wrapping up Human Biochemistry. He also authored Experimental Biochemistry [Wiley] and edited Receptor Purification, 2 volumes [Humana]. He is an author on over 300 journal articles and has been on the editorial boards of numerous journals, including Endocrinology, Oncology Research, Oncology Reports, Journal of Molecular Biochemistry, Chemtracts, Cancer Research, Apoptosis, and Critical Reviews in Eukaryotic Gene Expression.

Affiliations and Expertise

Emeritus Professor and Chair of Basic Sciences, Geisinger Commonwealth School of Medicine, Scranton, PA, USA

Ratings and Reviews