Biochemical Actions of Hormones V4

Biochemical Actions of Hormones V4

1st Edition - January 28, 1977

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  • Editor: Gerald Litwack
  • eBook ISBN: 9780323146326

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Biochemical Actions of Hormones, Volume IV explores the significant developments toward understanding the primary effects of hormones in cellular receptors at the molecular level. This volume is composed of nine chapters, and begins with a review of the developments in affinity labeling that relate principally to the determination of the mechanisms of hormone action. The following chapters examine the role of prostaglandins in ovarian function and the methods for measuring protein synthesis and degradation in the heart and skeletal muscle. These topics are followed by discussions on the regulation of cholesterol synthesis by individual hormones; the regulatory mechanisms modulating the responsiveness of pineal gland to ß-adrenergic receptor stimulation; and the unitary mechanism of thyrotropin-releasing hormone action in target cells. The remaining chapters cover the insulin binding and insulin receptors from a variety of tissues and diverse species. These chapters also look into the physiology, molecular action, and biological effects of androgens and cyclic adenosine monophosphate. This book will be of great benefit to endocrinologists.

Table of Contents

  • List of Contributors


    Contents of Previous Volumes

    Gordon M. Tomkins (1926-1975)

    1. Affinity Labeling as a Technique in Determining Hormone Mechanisms

    I. Introduction

    II. Fundamental Considerations

    III. Steroid Binding Sites

    IV. Cyclic Nucleotides

    V. Protein Hormones

    VI. Other Hormonal Systems

    VII. Invertebrate Hormones

    VIII. Plant Hormones

    IX. Conclusion


    2. Mechanism of Prostaglandin Action in Endocrine Glands

    I. Introduction

    II. Prostaglandins in Ovarian Function


    3. Regulation of Protein Synthesis and Degradation in Heart and Skeletal Muscle

    I. Introduction

    II. Measurements of the Rate of Protein Synthesis

    III. Localization of the Effects of Metabolic and Hormonal Factors to Steps in the Synthetic Pathway

    IV. Measurement of Protein Degradation and Factors Affecting the Rate

    V. Nutritional Factors Regulating Protein Turnover

    VI. Role of Insulin in the Regulation of Protein Turnover

    VII. Concluding Remarks


    4. Hormonal Regulation of Cholesterol Synthesis

    I. Introduction

    II. Pancreas

    III. Pituitary

    IV. Thyroid

    V. Adrenals

    VI. Regulation by an Interplay of Hormones

    VII. Regulation via Feedback Repression

    VIII. Regulation of the Level of Cholesterol

    IX. Regulation in Relation to Cardiovascular Disease

    X. Perspective


    5. The ß-Adrenergic Receptor and the Regulation of Circadian Rhythms in the Pineal Gland

    I. Biosynthesis of Melatonin

    II. Circadian Rhythms in the Pineal Gland

    III. Conclusion


    6. Cell Culture Studies of Thyrotropin-Releasing Hormone Action

    I. Introduction

    II. GH Cells Produce Both Growth Hormone and Prolactin

    III. Are Both Prolactin and Growth Hormone Produced by a Single Cell?

    IV. Biological Responses of GH Cells to TRH

    V. The TRH Receptor

    VI. Unitary Hypothesis of TRH Action

    VII. Spare TRH Receptors—Multiple TRH Receptors

    VIII. Summary


    7. The Insulin Receptor: Properties and Regulation

    I. Introduction

    II. Indirect Studies

    III. Early Direct Studies

    IV. Properties of the Insulin Receptor

    V. Regulation of Insulin Bioactivity at the Receptor Level

    VI. Summary and Conclusions


    8. Molecular Actions of Androgens

    I. Introduction

    II. Evidence for Selective Androgen Retention in Target Tissue

    III. Cellular Localization and Multiple Forms of Androgen Receptors

    IV. Structural Recognition in Androgen-Receptor Interaction

    V. Transformation and Nuclear Retention of Androgen-Receptor Complex

    VI. Acceptor Molecules and Receptor-Nucleoprotein Interaction

    VII. Differential Action of Androgens and Universality of Receptors

    VIII. Some Biodynamic Aspects of Androgen Receptors

    IX. Mode of Action of Antiandrogens

    X. RNA Synthesis

    XI. Protein Synthesis

    XII. Concluding Remarks—Interaction of Metals and Nucleotides with Steroid Receptors


    9. Actions of Cyclic AMP and Its Relationship to Transmitter Function in Nervous Tissue

    I. Introduction

    II. Metabolism of Cyclic AMP and Its Regulation

    III. Cytochemical Localization of Cyclic AMP

    IV. Actions of Cyclic AMP

    V. Conclusions



Product details

  • No. of pages: 550
  • Language: English
  • Copyright: © Academic Press 1977
  • Published: January 28, 1977
  • Imprint: Academic Press
  • eBook ISBN: 9780323146326

About the Editor

Gerald Litwack

Dr. Litwack is an accomplished and prolific author and editor at Elsevier. Spanning over 25 years, he has been the editor of over 55 volumes of Vitamins and Hormones, co-author of Hormones, editor of 14 volumes of Biochemical Actions of Hormones, co-editor of Actions of Hormones on Molecular Processes, author of Human Biochemistry and Disease, and just wrapping up Human Biochemistry. He also authored Experimental Biochemistry [Wiley] and edited Receptor Purification, 2 volumes [Humana]. He is an author on over 300 journal articles and has been on the editorial boards of numerous journals, including Endocrinology, Oncology Research, Oncology Reports, Journal of Molecular Biochemistry, Chemtracts, Cancer Research, Apoptosis, and Critical Reviews in Eukaryotic Gene Expression.

Affiliations and Expertise

Emeritus Professor and Chair of Basic Sciences, Geisinger Commonwealth School of Medicine, Scranton, PA, USA

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