Biochemical Actions of Hormones V2

Biochemical Actions of Hormones V2

1st Edition - January 1, 1972

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  • Editor: Gerald Litwack
  • eBook ISBN: 9780323146166

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Biochemical Actions of Hormones, Volume II is a 12-chapter text that surveys the significant developments toward understanding the primary effects of hormones in cellular receptors at the molecular level. This book starts with an overview of the genetic regulation by hormones and the role of cyclic adenosine monophosphate in hormonal response. These topics are followed by discussions on the hormone-dependent molecular mechanisms, which appear to participate in the regulation of cell proliferation and differentiation in this model system, as well as how multiple hormonal signals may serve to integrate a large number of complex regulatory mechanisms. A chapter deals with the comparative aspects of the physiology and biochemistry of insulin, with an emphasis on the molecular mode of action of insulin on metabolic processes. The remaining chapters deal with the physiology, mechanism of action, and biological effects of various hormones, including catecholamines, glucocorticoids, estrogens, progestins, gonadotropins, prolactin, adrenocorticotropic hormone, 25-hydroxycholecalciferol, and insect hormones. Endocrinologists will find this book invaluable.

Table of Contents

  • List of Contributors


    Contents of Volume I

    1. The Present Status of Genetic Regulation by Hormones

    I. Simple and Complex Regulation in Microorganisms

    II. The Metabolic Code

    III. Evolutionary Origins of Cell—Cell Interaction

    IV. Pleiotypic and Specific Control by Hormones

    V. Steroid Hormones and Gene Regulation


    2. Cyclic AMP and Hormone Action

    I. Introduction

    II. Discovery of Cyclic AMP

    III. Components of the Cyclic Mechanism

    IV. Assays

    V. Hormone Actions Mediated by Increased Cyclic AMP Levels

    VI. Hormones Acting via Decreased Intracellular Levels of Cyclic AMP

    VII. Responding Systems


    3. Multiple Hormonal Interactions. The Mammary Gland

    I. Introduction

    II. Hormonal Regulation of Mammary Cell Proliferation

    III. Hormone-Dependent Cell Differentiation

    IV. The Adrenocorticoid Hormone Requirement

    V. Hormonal Regulation of RNA Synthesis

    VI. Concluding Comments


    4. The Catecholamines

    I. Introduction

    II. Problems of Classification

    III. Effects of the Catecholamines

    IV. Summary



    5. Subcellular Actions of Glucocorticoids

    I. Introduction

    II. Subcellular Fates and Binding of Glucocorticoids

    III. Interactions of Carcinogens in the Corticosteroid Binding System of Liver Cytosol

    IV. Effects of Glucocorticoids on Metabolic Systems and Certain Enzymes

    V. On the Possible Origin of the Half-Lives of Certain Complex Enzymes and Its Relationship to Steroid Induction

    VI. Conclusions


    6. Insulin Actions on Carbohydrate and Lipid Metabolism

    I. Introduction

    II. Comparative Physiology and Biochemistry of Insulin Action

    III. Evidence That Many of the Physiological Effects of Insulin on Intermediary Metabolism Are Secondary to the Actions of Insulin on the Plasma Membrane

    IV. Specific Effects of Insulin on Carbohydrate and Fatty Acid Metabolism

    V. Summary and Conclusions



    7. Estrogens and Progestins

    I. Introduction

    II. Early Biochemical Effects in Target Cells

    III. Hormone-Receptor Interactions

    IV. Hormone—Receptor Interaction Pattern and Its Biochemical Significance


    8. Androgenic Regulation of Tissue Growth and Function

    I. Introduction

    II. Fate of Androgenic Steroids in Responsive Cells

    III. Do Low Molecular Weight "Second Messengers" Mediate the Actions of Androgens on Genital Tissues?

    IV. Androgenic Control of Metabolic Process Patterns


    9. Mechanism of Action of Gonadotropins and Prolactin

    I. Introduction

    II. Ovary

    III. Testis

    IV. Effect of Anterior Pituitary Hormones on Sexual Tissues

    V. Conclusions


    10. The Mechanism of Action of Adrenocorticotropic Hormone

    I. Introduction

    II. The ACTH Molecule

    III. Site of Action of ACTH

    IV. Hydroxylation Reactions in Steroidogenesis

    V. Sources of Reducing Equivalents in Steroidogenesis

    VI. Substrates for Steroidogenesis

    VII. Effects of ACTH

    VIII. The Involvement of Macromolecules in ACTH Responsiveness

    IX. Summary


    11. 25-Hydroxycholecalciferol: A Hormonal Form of Vitamin D

    I. Introduction and History

    II. Vitamin D Active Compounds

    III. Metabolism of the D Vitamins

    IV. Physiological Action of Vitamin D

    V. Biochemistry of Vitamin D Action

    VI. Vitamin D and Bone Disease

    VII. Role of Vitamin D in Calcium and Phosphate Homeostasis

    VIII. Summary


    12. Insect Hormones

    I. Introduction

    II. The Molting Hormone—Ecdysone

    III. Juvenile Hormone

    IV. Neurohormones

    V. Other Hormones


    Author Index

    Subject Index

Product details

  • No. of pages: 556
  • Language: English
  • Copyright: © Academic Press 1972
  • Published: January 1, 1972
  • Imprint: Academic Press
  • eBook ISBN: 9780323146166

About the Editor

Gerald Litwack

Dr. Litwack is an accomplished and prolific author and editor at Elsevier. Spanning over 25 years, he has been the editor of over 55 volumes of Vitamins and Hormones, co-author of Hormones, editor of 14 volumes of Biochemical Actions of Hormones, co-editor of Actions of Hormones on Molecular Processes, author of Human Biochemistry and Disease, and just wrapping up Human Biochemistry. He also authored Experimental Biochemistry [Wiley] and edited Receptor Purification, 2 volumes [Humana]. He is an author on over 300 journal articles and has been on the editorial boards of numerous journals, including Endocrinology, Oncology Research, Oncology Reports, Journal of Molecular Biochemistry, Chemtracts, Cancer Research, Apoptosis, and Critical Reviews in Eukaryotic Gene Expression.

Affiliations and Expertise

Emeritus Professor and Chair of Basic Sciences, Geisinger Commonwealth School of Medicine, Scranton, PA, USA

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