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Biochemical Actions of Hormones, Volume XIV is a compendium of papers dealing with DNA regulatory elements, leukotriene receptors, hormonal regulation of sodium-proton exchange activity, the structure of the mammalian progesterone receptor, stimulus-response, and signaling systems. One paper analyzes the hormonal factors that regulate the kinetic properties of the plasma membrane Na+ -H+ exchanger in epithelia and relates the control mechanisms to specific physiological function. Aqueous two-phase partitioning is a method that can be used in the study of steroid receptor activation and other conversions or interactions of steroid receptors. Using the two-phase partitioning, one can form a model of molecular changes during activation based on changes in the steroid receptor physico-chemical properties associated with the activation in vitro-phase. Another paper investigates the hypothesis that early androgenic modulation of nuclear effector-independent PKs is intimately related to the initial events in androgenic control of gene expression in the prostate. One paper describes the interaction between the estrogen receptor with DNA and the mechanism of transcription regulation by steroid receptors. Another paper reviews the role of GTP-binding proteins in receptor-mediated activation of phospholipase C, the formation and metabolism of novel inositol phosphates, as well as the possible role of protein kinase C in signal modulation. Micro-biologists, biochemists, molecular biologists, cellular biologists, and investigators in the field of cell research will find this collection useful.
1. DNA Regulatory Elements for Steroid Hormone Receptors
II. Hormone Regulatory Elements
III. Mechanism of Transcriptional Regulation
IV. Open Questions and Conclusions
2. Signalling Systems in Stimulus-Response Coupling
II. Receptor Coupling through GTP-Binding Proteins
III. Metabolism of Inositol Lipids
IV. Formation and Metabolism of Inositol Phosphates: Relationship to Ca2+ Release
V. Feedback Control by Activation of Protein Kinase C
3. Leukotriene Receptors and Signal Transduction Mechanism
II. The Leukotriene Receptors
III. Signal Transduction Systems
4. Hormonal Regulation of Na+-H+ Exchange Activity in Epithelia
II. Hormonal Effectors of Na+-H+ Exchange Activity
III. The Physiological Consequences of Hormonal Regulation of Na+-H+ Exchange Activity
IV. Independent and Dependent Effectors of Na+-H+ Exchange Activity
V. Temporally Distinct Hormonal Effects on Na+-H+ Exchange Activity
5. Aqueous Two-Phase Partitioning for the Study of Steroid Receptor Activation
II. Methods Used to Study Steroid-Receptor Activation
III. The Method of Aqueous Two-Phase Partitioning
IV. Activation of Glucocorticoid Receptors and Estrogen Receptors Is Associated with a Change in Their Partition Coefficients
V. Changes in Different Domains of the Glucocorticoid Receptor During Activation
VI. Hormone-Dependent Changes in Receptor Properties
VII. Kinetics of Glucocorticoid Receptor Activation
VIII. Modifiers of Receptor Activation
IX. Summary, Conclusions, and Perspectives
6. Androgenic Regulation of Prostatic Protein Phosphokinases and Protein Phosphorylation
II. The Experimental Model
III. Prostatic Nuclear Protein Kinase Reactions
IV. Prostatic Nuclear Protein Phosphokinases
V. Prostatic Cytosolic Protein Kinases and Phosphoproteins
VI. Factors That Influence Protein Kinase Reactions
VII. Prostatic Nuclear-Associated Protein Phosphatases
VIII. Age-Associated Changes in Prostatic Protein Kinases and Protein Phosphorylation
IX. Concluding Comments
7. Heat Shock Proteins and Steroid Hormone Receptors
II. Composition of the Avian Progesterone Receptor
III. Properties and Identification of the 90kDa Protein
IV. Proteins Associated with Other Steroid Receptors
V Possible Functions of hsp90
8. The Allosteric Estrogen- and DNA-Binding Mechanism of the Estrogen Receptor
II. The Site: Site Interactions of the Estrogen Receptor Induced by Steroid Binding
III. Modulation of the Estrogen Receptor's Affinity for DNA by Estradiol
9. Structure of the Mammalian Progesterone Receptor
I. Size of the Steroid Binding Subunit of the Progesterone Receptor
II. Non-Steroid Binding Subunits of the Progesterone Receptor
III. Receptor Phosphorylation
IV. Receptor Gene and Messenger RNA
- No. of pages:
- © Academic Press 1987
- 28th January 1987
- Academic Press
- eBook ISBN:
Dr. Litwack is an accomplished and prolific author and editor at Elsevier. Spanning over 25 years, he has been the editor of over 55 volumes of Vitamins and Hormones, co-author of Hormones, editor of 14 volumes of Biochemical Actions of Hormones, co-editor of Actions of Hormones on Molecular Processes, author of Human Biochemistry and Disease, and just wrapping up Human Biochemistry. He also authored Experimental Biochemistry [Wiley] and edited Receptor Purification, 2 volumes [Humana]. He is an author on over 300 journal articles and has been on the editorial boards of numerous journals, including Endocrinology, Oncology Research, Oncology Reports, Journal of Molecular Biochemistry, Chemtracts, Cancer Research, Apoptosis, and Critical Reviews in Eukaryotic Gene Expression.
Emeritus Professor and Chair of Basic Sciences, Geisinger Commonwealth School of Medicine, Scranton, PA, USA
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