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Biocatalysis in Green Solvents
- 1st Edition - August 2, 2022
- Editor: Pedro Lozano
- Language: English
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 9 1 3 0 6 - 5
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 1 4 2 5 - 3
Biocatalysis in Green Solvents offers a pragmatic overview and instruction in biocatalysis and enzymology of green solvents for sustainable industries and medicine, running f… Read more
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Request a sales quoteBiocatalysis in Green Solvents offers a pragmatic overview and instruction in biocatalysis and enzymology of green solvents for sustainable industries and medicine, running from concept to application. Here, international experts in the field discuss structure-function relationships of enzymes in ionic liquids (ILs) and examine how enzymes act as selective catalysts for fine biochemical synthesis in non-aqueous environments. Several integral green biochemical processes of biocatalytic transformation and pure product separation are described in detail.
Application focused chapters discuss the role of biocatalysis in creating and implementing deep eutectic solvents, biomass derived solvents, sub and supercritical fluids, carbon dioxide biphasic systems, and enzymatic membrane reactors, as well as applying these biocatalytic processes in drug discovery and production.
- Examines the structure-function relationships of enzymes in ionic liquids and biocatalytic processes for various applications across industry and medicine
- Includes clear instruction in core green biochemical processes—of (bio)catalytic transformation—and pure product separation
- Features chapter contributions from international experts across academia and industry
Basic and translational researchers in biochemistry, biotechnology, molecular biology, cellular biology, biomaterials and engineering, chemical biology, and sustainability science, life science researchers, bioengineers, clinicians and graduate students in the biosciences
- Cover image
- Title page
- Table of Contents
- Copyright
- Dedication
- List of contributors
- Foreword
- Preface
- Chapter 1. Biocatalysis, solvents, and green metrics in sustainable chemistry
- Abstract
- 1.1 Introduction to green chemistry and sustainability
- 1.2 The role of catalysis
- 1.3 Advantages and limitations of biocatalysis
- 1.4 The metrics of waste minimization
- 1.5 Atom economy: every atom counts
- 1.6 The E-factor: the environmental footprint of chemicals
- 1.7 Intrinsic E-factors and system boundaries
- 1.8 The climate factor
- 1.9 The nature and environmental impact of wastes
- 1.10 The role of solvents: the medium is the message
- 1.11 Bio-based solvents
- 1.12 Water as a reaction medium
- 1.13 Aqueous biphasic catalysis
- 1.14 Surfactants in water: aqueous micelles as nanoreactors
- 1.15 Neoteric solvents: ionic liquids and deep eutectic solvents
- 1.16 Concluding remarks
- References
- Chapter 2. Nonconventional biocatalysis: from organic solvents to green solvents
- Abstract
- 2.1 Introduction
- 2.2 Biocatalysis strengths and weaknesses at industrial level
- 2.3 Whole cell biocatalysis
- 2.4 Isolation of new biocatalysts
- 2.5 Recombinant technologies and enzyme evolution
- 2.6 Immobilization of biocatalysts
- 2.7 Volume-confined biocatalysis
- 2.8 Solvent engineering: organic media
- 2.9 From organic solvents to green solvents
- 2.10 Solvent-free biocatalysis
- 2.11 Conclusions
- References
- Chapter 3. Activation and stabilization of enzymes using ionic liquid engineering
- Abstract
- 3.1 Introduction
- 3.2 How to use an ionic liquids as a solvent for enzymatic reactions
- 3.3 Activation of lipase-catalyzed reactions using ionic liquid engineering
- 3.4 Laccase-catalyzed reactions in ionic liquids
- 3.5 Conclusions and future perspective of enzymatic reaction using ionic liquids
- References
- Further reading
- Chapter 4. Refolding ability of ionic liquids against denatured proteins
- Abstract
- 4.1 Introduction
- 4.2 Structural aspects of ionic liquids and their important applications in various bioscientific fields
- 4.3 Protein folding/unfolding mechanism
- 4.4 Overview of protein stability in ionic liquids
- 4.5 Refolding ability of ionic liquids on the perturbed proteins
- 4.6 Ammonium-based ionic liquids acted as refolding additives for denatured proteins
- 4.7 Imidazolium-based ionic liquids acted as refolding additives for perturbed proteins
- 4.8 Cholinium-based ionic liquids acted as refolding additives for perturbed proteins
- 4.9 Pyridinium-based ionic liquids acted as refolding additives for perturbed proteins
- 4.10 Pyrrolidinium-based ionic liquids acted as refolding additives for perturbed proteins
- 4.11 Phosphonium-based ionic liquids acted as refolding additives for perturbed proteins
- 4.12 Morpholinium-based ionic liquids acted as refolding additives for perturbed proteins
- 4.13 Conclusions
- References
- Chapter 5. Stability and stabilization of biocatalysts by ionic liquids
- Abstract
- 5.1 Introduction
- 5.2 Enzyme stability in ionic liquids: controlling factors
- 5.3 Enzyme stabilization by ionic liquids
- 5.4 Summary
- Acknowledgments
- References
- Chapter 6. Clean biocatalysis in sponge-like ionic liquids
- Abstract
- 6.1 Solvents, enzymes, and sustainable chemistry
- 6.2 Essentials of ionic liquids
- 6.3 Understanding biocatalysis in ionic liquids and beyond
- 6.4 Sponge-like ionic liquids: an enabling green tool to integrate reaction and separation processes
- 6.5 Biocatalytic production of flavor esters by using the sponge-like ionic liquid technology
- 6.6 Green biocatalytic production of biodiesel by using the sponge-like ionic liquid technology
- 6.7 Green biocatalytic production of monoacylglycerides by using the sponge-like ionic liquid technology
- 6.8 Conclusions
- Acknowledgements
- References
- Chapter 7. Biocatalysis in biphasic systems based on ionic liquids
- Abstract
- 7.1 Introduction
- 7.2 Biocatalysis in biphasic systems
- 7.3 Biocatalysis in aqueous biphasic systems
- 7.4 Concluding remarks
- Acknowledgments
- References
- Chapter 8. Biotransformations of carbohydrates in ionic liquids
- Abstract
- 8.1 Introduction
- 8.2 Ionic liquids
- 8.3 Ionic liquids can dissolve carbohydrates: properties and descriptions
- 8.4 Ionic liquids in carbohydrate synthesis
- 8.5 Enzymatic processes developed in ionic liquids for carbohydrate synthesis: lipases and glycosidases
- 8.6 Conclusions
- Acknowledgments
- References
- Chapter 9. Recent progress in ionic liquid-assisted processing and extraction of biopolymers
- Abstract
- 9.1 Introduction
- 9.2 Ionic liquid-assisted dissolution and processing of biopolymers
- 9.3 Relevant properties of ionic liquids for biopolymer dissolution and processing
- 9.4 Conclusions and prospects
- Acknowledgments
- References
- Chapter 10. Ionic liquids for biomass biotransformation
- Abstract
- 10.1 Introduction
- 10.2 Ionic liquid pretreatment prior to enzymatic transformation of biomass
- 10.3 In situ enzymatic transformation of biomass in ionic liquid-aqueous media
- 10.4 Biopolymer esterification: a promising alternative of lignocellulosic biomass valorization
- References
- Chapter 11. Biocatalysis in ionic liquids for a low carbon future
- Abstract
- 11.1 Introduction
- 11.2 Biocatalysis in ionic liquids
- 11.3 Chemicals and liquid fuels from biomass
- 11.4 Potential applications in a hydrogen economy
- 11.5 Conclusion and future prospects
- Funding
- References
- Chapter 12. Application of ionic liquids in pharmaceutics and medicine
- Abstract
- 12.1 Introduction
- 12.2 Physicochemical properties of ionic liquids of relevance for the pharmaceutical industry
- 12.3 Bioactivity of ionic liquids
- 12.4 Ionic liquids as enhancers in the pharmaceutical industry
- 12.5 Biological mechanism of interactions
- 12.6 Conclusions
- References
- Chapter 13. Biocatalysis in subcritical and supercritical fluids
- Abstract
- 13.1 Introduction
- 13.2 High-pressure reactors for biocatalysis
- 13.3 Biochemical reactions in supercritical fluids
- 13.4 Other applications of supercritical fluids in biocatalysis
- 13.5 Conclusion: the state of the art
- References
- Chapter 14. Biocatalytic processes in ionic liquids and supercritical carbon dioxide biphasic systems
- Abstract
- 14.1 Green chemistry: biocatalysis in organic versus neoteric solvents
- 14.2 Supercritical fluids and supercritical carbon dioxide
- 14.3 Ionic liquids
- 14.4 Biocatalysts in nonaqueous environments
- 14.5 Biocatalysis in supercritical CO2
- 14.6 Essentials of biocatalysis in ionic liquids
- 14.7 Phase behavior of ionic liquids and scCO2 mixtures
- 14.8 Biocatalytic processes in ionic liquid/scCO2 biphasic systems
- 14.9 Conclusions
- Acknowledgments
- References
- Chapter 15. Enzymatic membrane reactors and nonconventional solvents
- Abstract
- 15.1 Introduction
- 15.2 Membrane separation processes
- 15.3 Integration of a membrane separation and a catalytic reaction
- 15.4 Enzymatic membrane reactors
- 15.5 Immobilization of enzymes
- 15.6 Enzymes immobilized on membranes
- 15.7 Enzymatic membrane reactors and nonconventional solvents
- 15.8 Conclusions
- References
- Chapter 16. Applied biocatalysis in deep eutectic solvents
- Abstract
- 16.1 Introduction
- 16.2 Hydrolases
- 16.3 Redox enzymes
- 16.4 Lyases and transferases in single transformations using deep eutectic solvents as solvents
- 16.5 Multicatalytic transformations
- 16.6 Conclusions and perspectives
- References
- Chapter 17. Biocatalysis and green solvents: trends, needs, and opportunities
- Abstract
- 17.1 On the need of using green solvents to reach truly sustainable processes
- 17.2 Solvent-free processes in biocatalysis: keeping things as simple as possible, but not simpler!
- 17.3 Biogenic solvents for biocatalysis: recent examples related to 2-methyltetrahydrofuran, cyclopentyl-methyl ether and cyrene
- 17.4 Deep eutectic solvents: from proof of concept to continuous biocatalytic processes
- 17.5 Concluding remarks
- References
- Index
- No. of pages: 560
- Language: English
- Edition: 1
- Published: August 2, 2022
- Imprint: Academic Press
- Paperback ISBN: 9780323913065
- eBook ISBN: 9780323914253
PL
Pedro Lozano
Dr. Pedro Lozano is a Professor of Biochemistry and Molecular Biology at the University of Murcia in Murcia, Spain. Born in Ceuti, Spain in 1961, Prof. Lozano received his PhD at the University of Murcia in 1988. Between 1990 and 1991, he spent two years at the Centre de Bioingénierie Gilbert Durand, Toulouse (France) as a post-doctoral fellow. In 1993, he returned to the University of Murcia (Spain) as Lecturer in Biochemistry and Molecular Biology, later being promoted to Full Professor in 2004. His research activity has always been related to enzyme technology in ionic liquids and supercritical fluids. In 2002, he published a paper on the first continuous green biocatalytic reactor, based on the combination of enzymes with ILs and scCO2 able to directly provide pure products.
Affiliations and expertise
Professor of Biochemistry and Molecular Biology, University of Murcia in Murcia, Murcia, Murcia, SpainRead Biocatalysis in Green Solvents on ScienceDirect