Bioactive Nutraceuticals and Dietary Supplements in Neurological and Brain Disease

1st Edition

Prevention and Therapy

Editors: Ronald Ross Watson Victor Preedy
Print ISBN: 9780128103029
eBook ISBN: 9780124115293
Imprint: Academic Press
Published Date: 11th September 2014
Page Count: 528
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Nutritional supplement research concerning brain health and neurological disease is becoming an important focus. While nutritional supplements are very popular for general health and well being, the effectiveness of common supplements and their impact on general brain health and for the treatment or prevention of neurological disease is not clearly understood. This comprehensive introduction to bioactive nutraceuticals for brain and neurological provides a foundation review for research neuroscientists, clinical neurologists, pharmacology researchers and nutrition scientists on what we know now about these supplements and the brain and where focused research is still necessary.

Key Features

  • Foundational review content covering nutrition and brain and neurological health
  • Reviews known nutritional supplements and impact on brain and neurological health
  • Comprehensive coverage ideal for research scientists and clinical practitioners


Neuroscience\Neurology Research, Nutrition Research

Table of Contents

  • Preface
  • About the Editors
  • <li>Acknowledgments</li> <li>Section I. The Role of Complementary and Alternative Supplements: An Overview of Mechanisms of Action and Neurological Targets<ul><li>Chapter 1. Anti-Inflammatory Properties of Botanical Extracts Contribute to Their Protective Effects in Brain Edema in Cerebral Ischemia<ul><li>Introduction</li><li>Role of ProInflammatory Proteins in Brain Edema in Ischemic Injury</li><li>The Role of Botanical Extracts in Attenuating Brain Edema and Cell Swelling in Ischemia</li><li>The Role of Botanical Extracts in Reducing Inflammation in Injury</li><li>Conclusion</li><li>Conflict of Interest Statement</li></ul></li><li>Chapter 2. Blueberry Polyphenols and Neuroprotection<ul><li>Introduction</li><li>Blueberry Polyphenols</li><li>Neurodegeneration: Mechanisms and Implications for Brain Performance</li><li>Neuroprotective Effects of Blueberry Polyphenols</li><li>Conclusions</li></ul></li><li>Chapter 3. Neuropharmacology Effects of Saffron (<i>Crocus sativus</i>) and Its Active Constituents<ul><li>Introduction</li><li>Animal Studies</li><li>Clinical Studies</li><li>Conclusion</li></ul></li><li>Chapter 4. Lutein, Brain, and Neurological Functions<ul><li>Adults and Cognitive Function</li><li>Eye&#x2013;Brain Connection</li><li>Carotenoids in Eye and Brain</li><li>Early Life Period</li><li>Influence of Carotenoids on Brain Functions</li><li>Lutein and Cognitive Function</li><li>Lutein and Parkinson&#x2019;s Disease</li><li>Lutein and Huntington&#x2019;s Disease</li><li>Conclusion</li></ul></li><li>Chapter 5. Bioactive Nutrients for Brain Health<ul><li>Diet and Cognitive Function</li></ul></li><li>Chapter 6. Using Paullinia cupana (Guarana) to Treat Fatigue and Other Symptoms of Cancer and Cancer Treatment<ul><li>Introduction</li><li><i>Paullinia cupana</i> (guarana)</li><li>Cancer-Related Fatigue</li><li>The Use of Guarana for CRF Treatment</li><li>Mechanism of Action of Guarana in Patient


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About the Editor

Ronald Ross Watson

Ronald R. Watson, Ph.D., attended the University of Idaho but graduated from Brigham Young University in Provo, Utah, with a degree in chemistry in 1966. He earned his Ph.D. in biochemistry from Michigan State University in 1971. His postdoctoral schooling in nutrition and microbiology was completed at the Harvard School of Public Health, where he gained 2 years of postdoctoral research experience in immunology and nutrition. From 1973 to 1974 Dr. Watson was assistant professor of immunology and performed research at the University of Mississippi Medical Center in Jackson. He was assistant professor of microbiology and immunology at the Indiana University Medical School from 1974 to 1978 and associate professor at Purdue University in the Department of Food and Nutrition from 1978 to 1982. In 1982 Dr. Watson joined the faculty at the University of Arizona Health Sciences Center in the Department of Family and Community Medicine of the School of Medicine. He is currently professor of health promotion sciences in the Mel and Enid Zuckerman Arizona College of Public Health. Dr. Watson is a member of several national and international nutrition, immunology, cancer, and alcoholism research societies. Among his patents he has one on a dietary supplement; passion fruit peel extract with more pending. He continues to do research in animals and in clinical trials on dietary supplements and health including studies using omega-3 fatty acids in heart disease prevention and therapy. For 30 years he was funded by Wallace Research Foundation to study dietary supplements in health promotion. Dr. Watson has edited more than 110 books on nutrition, dietary supplements and over-the-counter agents, and drugs of abuse as scientific reference books. He has published more than 500 research and review articles.

Affiliations and Expertise

Mel and Enid Zuckerman College of Public Health, and School of Medicine, University of Arizona, Tucson, AZ, USA

Victor Preedy

Victor R. Preedy BSc, PhD, DSc, FRSB, FRSPH, FRCPath, FRSC is a senior member of King's College London. He is also Director of the Genomics Centre and a member of the Faculty of Life Sciences and Medicine. Professor Preedy has longstanding academic interests in substance misuse especially in relation to health and well being. He is a member of the Editorial Board of Drug and Alcohol Dependence and a founding member of the Editorial Board of Addiction Biology. In his career Professor Preedy was Reader at the Addictive Behaviour Centre at The University of Roehampton, and also Reader at the School of Pharmacy (now part of University College London; UCL). Professor Preedy is Editor of the influential works The Handbook Of Alcohol Related Pathology, The Neuropathology of Drug Addictions and Substance Misuse and The Handbook of Cannabis and Related Pathologies (all published by Academic Press-Elsevier). Professor Preedy graduated in 1974 with an Honours Degree in Biology and Physiology with Pharmacology. He gained his University of London PhD in 1981. In 1992, he received his Membership of the Royal College of Pathologists and in 1993 he gained his second doctoral degree (DSc). Professor Preedy was elected as a Fellow of the Institute of Biology in 1995 and also as a Fellow to the Royal College of Pathologists in 2000. He was then elected as a Fellow of the Royal Society for the Promotion of Health (2004) and The Royal Institute of Public Health and Hygiene (2004). In 2009, Professor Preedy became a Fellow of the Royal Society for Public Health and in 2012 a Fellow of the Royal Society of Chemistry. To his credit, Professor Preedy has published over 600 articles, which includes peer-reviewed manuscripts based on original research, abstracts and symposium presentations, reviews and numerous books and volumes.

Affiliations and Expertise

Department of Dietetics, King's College London, UK


"...this book is helpful as a review of the current body of literature on foods and supplements that can aid in combating neurological diseases.  Score: 80 - 3 Stars" --Doody's