Bioactive Nutraceuticals and Dietary Supplements in Neurological and Brain Disease

1st Edition

Prevention and Therapy

Editors: Ronald Ross Watson Victor Preedy
Hardcover ISBN: 9780124114623
eBook ISBN: 9780124115293
Imprint: Academic Press
Published Date: 11th September 2014
Page Count: 528
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Nutritional supplement research concerning brain health and neurological disease is becoming an important focus. While nutritional supplements are very popular for general health and well being, the effectiveness of common supplements and their impact on general brain health and for the treatment or prevention of neurological disease is not clearly understood. This comprehensive introduction to bioactive nutraceuticals for brain and neurological provides a foundation review for research neuroscientists, clinical neurologists, pharmacology researchers and nutrition scientists on what we know now about these supplements and the brain and where focused research is still necessary.

Key Features

  • Foundational review content covering nutrition and brain and neurological health
  • Reviews known nutritional supplements and impact on brain and neurological health
  • Comprehensive coverage ideal for research scientists and clinical practitioners


Neuroscience\Neurology Research, Nutrition Research

Table of Contents

  • Preface
  • About the Editors
  • <li>Acknowledgments</li> <li>Section I. The Role of Complementary and Alternative Supplements: An Overview of Mechanisms of Action and Neurological Targets<ul><li>Chapter 1. Anti-Inflammatory Properties of Botanical Extracts Contribute to Their Protective Effects in Brain Edema in Cerebral Ischemia<ul><li>Introduction</li><li>Role of ProInflammatory Proteins in Brain Edema in Ischemic Injury</li><li>The Role of Botanical Extracts in Attenuating Brain Edema and Cell Swelling in Ischemia</li><li>The Role of Botanical Extracts in Reducing Inflammation in Injury</li><li>Conclusion</li><li>Conflict of Interest Statement</li></ul></li><li>Chapter 2. Blueberry Polyphenols and Neuroprotection<ul><li>Introduction</li><li>Blueberry Polyphenols</li><li>Neurodegeneration: Mechanisms and Implications for Brain Performance</li><li>Neuroprotective Effects of Blueberry Polyphenols</li><li>Conclusions</li></ul></li><li>Chapter 3. Neuropharmacology Effects of Saffron (<i>Crocus sativus</i>) and Its Active Constituents<ul><li>Introduction</li><li>Animal Studies</li><li>Clinical Studies</li><li>Conclusion</li></ul></li><li>Chapter 4. Lutein, Brain, and Neurological Functions<ul><li>Adults and Cognitive Function</li><li>Eye&#x2013;Brain Connection</li><li>Carotenoids in Eye and Brain</li><li>Early Life Period</li><li>Influence of Carotenoids on Brain Functions</li><li>Lutein and Cognitive Function</li><li>Lutein and Parkinson&#x2019;s Disease</li><li>Lutein and Huntington&#x2019;s Disease</li><li>Conclusion</li></ul></li><li>Chapter 5. Bioactive Nutrients for Brain Health<ul><li>Diet and Cognitive Function</li></ul></li><li>Chapter 6. Using Paullinia cupana (Guarana) to Treat Fatigue and Other Symptoms of Cancer and Cancer Treatment<ul><li>Introduction</li><li><i>Paullinia cupana</i> (guarana)</li><li>Cancer-Related Fatigue</li><li>The Use of Guarana for CRF Treatment</li><li>Mechanism of Action of Guarana in Patient


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About the Editor

Ronald Ross Watson

Ronald Ross Watson PhD is a professor of Health Promotion Sciences in the University of Arizona Mel and Enid Zuckerman College of Public Health. He was one of the founding members of this school serving the mountain west of the USA. He is a professor of Family and Community Medicine in the School of Medicine at the University of Arizona. He began his research in public health at the Harvard School of Public Health as a fellow in 1971 doing field work on vaccines in Saudi Arabia. He has done clinical studies in Colombia, Iran, Egypt, Saudi Arabia, and USA which provides a broad international view of public health. He has served in the military reserve hospital for 17 years with extensive training in medical responses to disasters as the chief biochemistry officer of a general hospital, retiring at a Lt. Colonel. He published 450 papers, and presently directs or has directed several NIH funded biomedical grants relating to alcohol and disease particularly immune function and cardiovascular effects including studying complementary and alternative medicines. Professor Ronald Ross Watson was Director of a National Institutes of Health funded Alcohol Research Center for 5 years. The main goal of the Center was to understand the role of ethanol-induced immunosuppression on immune function and disease resistance in animals. He is an internationally recognized alcohol-researcher, nutritionist and immunologist. He also initiated and directed other NIH-associated work at The University of Arizona, College of Medicine. Dr. Watson has funding from companies and non-profit foundations to study bioactive foods’ components in health promotion. Professor Watson attended the University of Idaho, but graduated from Brigham Young University in Provo, Utah, with a degree in Chemistry in 1966. He completed his Ph.D. degree in 1971 in Biochemistry from Michigan State University. His postdoctoral schooling was completed at the Harvard School of Public Health in Nutrition and Micro

Affiliations and Expertise

Mel and Enid Zuckerman College of Public Health, School of Medicine, University of Arizona, Tucson, AZ, USA

Victor Preedy

Victor R. Preedy BSc, PhD, DSc, FRSB, FRSPH, FRCPath, FRSC is a senior member of King's College London. He is also Director of the Genomics Centre and a member of the Faculty of Life Sciences and Medicine. Professor Preedy has longstanding academic interests in substance misuse especially in relation to health and well being. He is a member of the Editorial Board of Drug and Alcohol Dependence and a founding member of the Editorial Board of Addiction Biology. In his career Professor Preedy was Reader at the Addictive Behaviour Centre at The University of Roehampton, and also Reader at the School of Pharmacy (now part of University College London; UCL). Professor Preedy is Editor of the influential works The Handbook Of Alcohol Related Pathology, The Neuropathology of Drug Addictions and Substance Misuse and The Handbook of Cannabis and Related Pathologies (all published by Academic Press-Elsevier). Professor Preedy graduated in 1974 with an Honours Degree in Biology and Physiology with Pharmacology. He gained his University of London PhD in 1981. In 1992, he received his Membership of the Royal College of Pathologists and in 1993 he gained his second doctoral degree (DSc). Professor Preedy was elected as a Fellow of the Institute of Biology in 1995 and also as a Fellow to the Royal College of Pathologists in 2000. He was then elected as a Fellow of the Royal Society for the Promotion of Health (2004) and The Royal Institute of Public Health and Hygiene (2004). In 2009, Professor Preedy became a Fellow of the Royal Society for Public Health and in 2012 a Fellow of the Royal Society of Chemistry. To his credit, Professor Preedy has published over 600 articles, which includes peer-reviewed manuscripts based on original research, abstracts and symposium presentations, reviews and numerous books and volumes.

Affiliations and Expertise

Department of Dietetics, King's College London, UK


"...this book is helpful as a review of the current body of literature on foods and supplements that can aid in combating neurological diseases.  Score: 80 - 3 Stars" --Doody's