Bioactive Food as Dietary Interventions for Diabetes

1st Edition

Bioactive Foods in Chronic Disease States

Editors: Ronald Ross Watson Victor Preedy
Print ISBN: 9780123971531
eBook ISBN: 9780123977625
Imprint: Academic Press
Published Date: 22nd October 2012
Page Count: 658
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The role of diet in the prevention, control and treatment of diabetes continues to provide significant opportunity for non-pharmaceutical interventions for many of the over 20 million people who live with this disease. Looking beyond traditional dietary controls may lead to more effective, cost efficient, and flexible options for many patients.

Bioactive Food as Dietary Interventions for Diabetes is the only available scientific resource focused on exploring the latest advances in bioactive food research, and the potential benefit of bioactive food choice on the diabetic condition. Written by experts from around the world, it presents important information that can help improve the health of those at risk for diabetes and diabetes related conditions using food selection as its foundation.

Key Features

  • Focuses on the role of bioactive foods in addressing pre-diabetes symptoms, their potential to complement other treatments for those suffering from diabetes and diabetic-related obesity and other health issues
  • Documents foods that can affect metabolic syndrome and ways the associated information could be used to understand other diseases that share common etiological pathways
  • Includes insights from experts from around the world, providing global perspectives and options based on various regional foods


Nutritionists, dieticians, and biomedical researchers whose focus is in identifying pre-diabetic symptoms, diabetes, and its relationship to obesity and weight issues; food scientists targeting health-related product development.

Table of Contents

Preface: Diabetes Food


Chapter 1. Role of Oxidative Stress in the Pathogenesis of Insulin Resistance and Type 2 Diabetes


1 Introduction

2 Systemic Glucose Homeostasis is a Multiorgan Process

3 Glucose Dysregulation: The Pathogenesis of Insulin Resistance

4 Origins of Oxidative Stress in Various Cell Types

5 Mechanisms of Oxidative Stress-Associated Insulin Resistance

6 Utility of Select Antioxidants as Interventions in Oxidative Stress-Associated Insulin Resistance

7 Conclusion and Perspectives



Relevant Websites

Chapter 2. Diabetes and the Role of Dietary Supplements

1 Introduction

2 Alpha-Lipoic Acid

3 Omega-3 Oils

4 Chromium

5 Gymnemma Sylvestre

6 Fenugreek

7 Vitamin D

8 Conclusion



Chapter 3. Government Regulation of Dietary Supplements and Foods: Role in Diabetes

1 Introduction

2 Nongovernmental Recommendations for Diabetics

3 NHPS for Diabetics

4 Food Label Information and Nutrition – Health Claims

5 Nutrition Recommendations for Diabetics

6 Conclusions


Chapter 4. Diabetes as an Immune Dysfunction Syndrome

1 Diagnostic Laboratory Testing

2 Key Clinical Issues

3 Diagnoses and Comorbidities

4 Conclusion


Relevant Websites

Chapter 5. Antihyperglycemic Potential of Secoisolaricinol Diglucoside


1 Introduction

2 Botanical Description

3 Antihyperglycemic Potential of Secoisolaricinol diglucoside

4 Adverse Effects and Reactions (Allergies and Toxicity)

5 Summary Points


Chapter 6. Antidiabetic Potential of Trigonelline and 4-Hydroxyisoleucine in Fenugreek

1 In


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About the Editor

Ronald Ross Watson

Ronald R. Watson, Ph.D., attended the University of Idaho but graduated from Brigham Young University in Provo, Utah, with a degree in chemistry in 1966. He earned his Ph.D. in biochemistry from Michigan State University in 1971. His postdoctoral schooling in nutrition and microbiology was completed at the Harvard School of Public Health, where he gained 2 years of postdoctoral research experience in immunology and nutrition. From 1973 to 1974 Dr. Watson was assistant professor of immunology and performed research at the University of Mississippi Medical Center in Jackson. He was assistant professor of microbiology and immunology at the Indiana University Medical School from 1974 to 1978 and associate professor at Purdue University in the Department of Food and Nutrition from 1978 to 1982. In 1982 Dr. Watson joined the faculty at the University of Arizona Health Sciences Center in the Department of Family and Community Medicine of the School of Medicine. He is currently professor of health promotion sciences in the Mel and Enid Zuckerman Arizona College of Public Health. Dr. Watson is a member of several national and international nutrition, immunology, cancer, and alcoholism research societies. Among his patents he has one on a dietary supplement; passion fruit peel extract with more pending. He continues to do research in animals and in clinical trials on dietary supplements and health including studies using omega-3 fatty acids in heart disease prevention and therapy. For 30 years he was funded by Wallace Research Foundation to study dietary supplements in health promotion. Dr. Watson has edited more than 110 books on nutrition, dietary supplements and over-the-counter agents, and drugs of abuse as scientific reference books. He has published more than 500 research and review articles.

Affiliations and Expertise

Mel and Enid Zuckerman College of Public Health, and School of Medicine, University of Arizona, Tucson, AZ, USA

Victor Preedy

Victor R. Preedy BSc, PhD, DSc, FRSB, FRSPH, FRCPath, FRSC is a senior member of King's College London. He is also Director of the Genomics Centre and a member of the Faculty of Life Sciences and Medicine. Professor Preedy has longstanding academic interests in substance misuse especially in relation to health and well being. He is a member of the Editorial Board of Drug and Alcohol Dependence and a founding member of the Editorial Board of Addiction Biology. In his career Professor Preedy was Reader at the Addictive Behaviour Centre at The University of Roehampton, and also Reader at the School of Pharmacy (now part of University College London; UCL). Professor Preedy is Editor of the influential works The Handbook Of Alcohol Related Pathology, The Neuropathology of Drug Addictions and Substance Misuse and The Handbook of Cannabis and Related Pathologies (all published by Academic Press-Elsevier). Professor Preedy graduated in 1974 with an Honours Degree in Biology and Physiology with Pharmacology. He gained his University of London PhD in 1981. In 1992, he received his Membership of the Royal College of Pathologists and in 1993 he gained his second doctoral degree (DSc). Professor Preedy was elected as a Fellow of the Institute of Biology in 1995 and also as a Fellow to the Royal College of Pathologists in 2000. He was then elected as a Fellow of the Royal Society for the Promotion of Health (2004) and The Royal Institute of Public Health and Hygiene (2004). In 2009, Professor Preedy became a Fellow of the Royal Society for Public Health and in 2012 a Fellow of the Royal Society of Chemistry. To his credit, Professor Preedy has published over 600 articles, which includes peer-reviewed manuscripts based on original research, abstracts and symposium presentations, reviews and numerous books and volumes.

Affiliations and Expertise

Department of Dietetics, King's College London, UK


"Watson and Preedy assemble an international group of researchers for 47 chapters that examine the role of foods, herbs, and novel extracts in moderating the pathology leading to diabetes and its risk factors for other chronic diseases."--Reference and Research Book News, December 2012