The role of diet in the prevention, control and treatment of diabetes continues to provide significant opportunity for non-pharmaceutical interventions for many of the over 20 million people who live with this disease. Looking beyond traditional dietary controls may lead to more effective, cost efficient, and flexible options for many patients.

Bioactive Food as Dietary Interventions for Diabetes is the only available scientific resource focused on exploring the latest advances in bioactive food research, and the potential benefit of bioactive food choice on the diabetic condition. Written by experts from around the world, it presents important information that can help improve the health of those at risk for diabetes and diabetes related conditions using food selection as its foundation.

Key Features

  • Focuses on the role of bioactive foods in addressing pre-diabetes symptoms, their potential to complement other treatments for those suffering from diabetes and diabetic-related obesity and other health issues
  • Documents foods that can affect metabolic syndrome and ways the associated information could be used to understand other diseases that share common etiological pathways
  • Includes insights from experts from around the world, providing global perspectives and options based on various regional foods


Nutritionists, dieticians, and biomedical researchers whose focus is in identifying pre-diabetic symptoms, diabetes, and its relationship to obesity and weight issues; food scientists targeting health-related product development.

Table of Contents

Preface: Diabetes Food


Chapter 1. Role of Oxidative Stress in the Pathogenesis of Insulin Resistance and Type 2 Diabetes


1 Introduction

2 Systemic Glucose Homeostasis is a Multiorgan Process

3 Glucose Dysregulation: The Pathogenesis of Insulin Resistance

4 Origins of Oxidative Stress in Various Cell Types

5 Mechanisms of Oxidative Stress-Associated Insulin Resistance

6 Utility of Select Antioxidants as Interventions in Oxidative Stress-Associated Insulin Resistance

7 Conclusion and Perspectives



Relevant Websites

Chapter 2. Diabetes and the Role of Dietary Supplements

1 Introduction

2 Alpha-Lipoic Acid

3 Omega-3 Oils

4 Chromium

5 Gymnemma Sylvestre

6 Fenugreek

7 Vitamin D

8 Conclusion



Chapter 3. Government Regulation of Dietary Supplements and Foods: Role in Diabetes

1 Introduction

2 Nongovernmental Recommendations for Diabetics

3 NHPS for Diabetics

4 Food Label Information and Nutrition – Health Claims

5 Nutrition Recommendations for Diabetics

6 Conclusions


Chapter 4. Diabetes as an Immune Dysfunction Syndrome

1 Diagnostic Laboratory Testing

2 Key Clinical Issues

3 Diagnoses and Comorbidities

4 Conclusion


Relevant Websites

Chapter 5. Antihyperglycemic Potential of Secoisolaricinol Diglucoside


1 Introduction

2 Botanical Description

3 Antihyperglycemic Potential of Secoisolaricinol diglucoside

4 Adverse Effects and Reactions (Allergies and Toxicity)

5 Summary Points


Chapter 6. Antidiabetic Potential of Trigonelline and 4-Hydroxyisoleucine in Fenugreek

1 In


No. of pages:
© 2013
Academic Press
Print ISBN:
Electronic ISBN:

About the authors

Ronald Ross Watson

Ronald R. Watson, Ph.D., attended the University of Idaho but graduated from Brigham Young University in Provo, Utah, with a degree in chemistry in 1966. He earned his Ph.D. in biochemistry from Michigan State University in 1971. His postdoctoral schooling in nutrition and microbiology was completed at the Harvard School of Public Health, where he gained 2 years of postdoctoral research experience in immunology and nutrition. From 1973 to 1974 Dr. Watson was assistant professor of immunology and performed research at the University of Mississippi Medical Center in Jackson. He was assistant professor of microbiology and immunology at the Indiana University Medical School from 1974 to 1978 and associate professor at Purdue University in the Department of Food and Nutrition from 1978 to 1982. In 1982 Dr. Watson joined the faculty at the University of Arizona Health Sciences Center in the Department of Family and Community Medicine of the School of Medicine. He is currently professor of health promotion sciences in the Mel and Enid Zuckerman Arizona College of Public Health. Dr. Watson is a member of several national and international nutrition, immunology, cancer, and alcoholism research societies. Among his patents he has one on a dietary supplement; passion fruit peel extract with more pending. He continues to do research in animals and in clinical trials on dietary supplements and health including studies using omega-3 fatty acids in heart disease prevention and therapy. For 30 years he was funded by Wallace Research Foundation to study dietary supplements in health promotion. Dr. Watson has edited more than 110 books on nutrition, dietary supplements and over-the-counter agents, and drugs of abuse as scientific reference books. He has published more than 500 research and review articles.


"Watson and Preedy assemble an international group of researchers for 47 chapters that examine the role of foods, herbs, and novel extracts in moderating the pathology leading to diabetes and its risk factors for other chronic diseases."--Reference and Research Book News, December 2012