Description

This work contains over thirty chapters by leading researchers in the field of oxidative biology, originally presented as articles in an extended Forum in the highly-cited journal, Free Radical Biology & Medicine. The papers in this Forum (or Symposium-in-print) spanned seven issues of the journal, over many months. This is the first time that all of these expert contributions are presented in one place.

Reliable methods for measuring OSS in organisms are essential. These would, amongst other things, offer applications as early warning signals for cancer and heart disease - eventually giving a range of measurable oxidation products best related to any given disease state.

Additional observations relevant to OSS include: how much do measures of OSS vary in a group of humans? Does OSS decrease as a result of life-change factors and does it increase with age? With disease? With stress? Can a non-invasive, reliable, reputable measure of OSS be identified?

This informative book provides the reader with the latest status of studies into OSS, currently used examples of BOSS, and answers to at least some of the questions posed above.

Table of Contents

Introduction to oxidative stress status (OSS) (W.A. Pryor). 1. Oxidative stress status: OSS, BOSS, and "Wild Bill" Donovan (W.A. Pryor). 2. Novel HPLC analysis of tocopherols, tocotrienols, and cholesterol in tissue (E. Katsanidis, P.B. Addis). 3. Baseline diene conjugation in LDL lipids: an indicator of circulating oxidized LDL (M. Ahotupa, T.J. Vasankari). 4. Stable markers of oxidant damage to proteins and their application in the study of human disease (M.J. Davies, et al.). 5. Measurement of oxidant-induced signal transduction proteins using cell imaging (M.E. Poynter, et al.). 6. In vivo total antioxidant capacity: comparison of different analytical methods (R.L. Prior, Guohua Cao). 7. Clinical application of breath biomarkers of oxidative stress status (T.H. Risby, S.S. Sehnert). 8. Analysis of oxidized heme proteins and its application to multiple antioxidant protection (A.L. Tappel). 9. Oxidative stress status - the second set (W.A. Pryor). 10. Measurement of F2-isoprostanes as an index of oxidative stress in vivo (L.J. Roberts II, J.D. Morrow). 11. Methods for measuring ethane and pentane in expired air from rats and humans (M.D. Knutson, G.J. Handelman, F.E. Viteri). 12. Measurement of 3-nitrotyrosine and 5-nitro-&ggr;-tocopherol by high-performance liquid chromatography with electrochemical detection (K. Hensley, K.S. Williamson, R.A. Floyd). 13. Detection of oxidative DNA damage in human sperm and its association with sperm function and male infertility (Han-Ming Shen, Choon-Nam Ong). 14. Oxidative stress status - the third set (W.A. Pryor). 15. Biomarkers of oxidative stress study: are plasma antioxidants markers of CC14 poisoning? (M.B. Kadiiska, et al.). 16. Analysis of hepatic oxidative stress status by electron

Details

No. of pages:
296
Language:
English
Copyright:
© 2001
Published:
Imprint:
Elsevier Science
Electronic ISBN:
9780080929927
Print ISBN:
9780444509574
Print ISBN:
9780444567086

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