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Big on Bk
Current Insights into the Function of Large Conductance Voltage- and Ca2+- Activated K+ Channels at the Molecular, Cellular and Systemic Levels
1st Edition, Volume 128 - May 26, 2016
Editor: Candice Contet
Language: English
Hardback ISBN:9780128036198
9 7 8 - 0 - 1 2 - 8 0 3 6 1 9 - 8
eBook ISBN:9780128036471
9 7 8 - 0 - 1 2 - 8 0 3 6 4 7 - 1
Big on Bk: Current Insights into the Function of Large Conductance Voltage- and Ca2+- Activated K+ Channels at the Molecular, Cellular and Systemic Levels, a volume in the Inter…Read more
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Big on Bk: Current Insights into the Function of Large Conductance Voltage- and Ca2+- Activated K+ Channels at the Molecular, Cellular and Systemic Levels, a volume in the International Review of Neurobiology series, is a comprehensive overview of the state-of-the-art research into this area. It reviews current knowledge and understanding, and also provides a starting point for researchers and practitioners entering the field.
The latest volume in the International Review of Neurobiology series
Provides a broad coverage of subject matter at the molecular, cellular and systemic levels
Presents an ideal resource for researchers and practitioners, and those just entering the field
Primarily medical scientists and physicians (diabetologists, endocrinologists, neurologists, internists)
Preface
Chapter One: Biophysics of BK Channel Gating
Abstract
1 Introduction
2 Voltage-Dependent Gating in BK Channels
3 Ligand-Dependent Gating in BK Channels
4 The BK Allosteric Gating Mechanism
5 The Extraordinary Conductance of BK Channels
6 Concluding Remarks: The BK Channel as a Rebel and a Model
Acknowledgments
Chapter Two: Modulation of BK Channel Function by Auxiliary Beta and Gamma Subunits
Abstract
1 Introduction
2 Discovery
3 Structural Characteristics
4 Modulation of the BK Channel's Biophysical Properties by β Subunits
5 Modulation of the BK Channel's Biophysical Properties by γ Subunits
6 Modulation of the BK Channel's Pharmacological Properties by β and γ Subunits
7 Stoichiometry
8 Physiological and Pathological Relevance or Roles
9 Perspectives
Acknowledgment
Chapter Three: Posttranscriptional and Posttranslational Regulation of BK Channels
Abstract
1 Introduction
2 Posttranscriptional Regulation
3 Posttranslational Modification
4 Conclusions and Perspectives
Acknowledgments
Chapter Four: Protein Network Interacting with BK Channels
Abstract
1 Introduction
2 Calcium Channels that Functionally Couple with BK Channels
3 Actin Cytoskeleton
4 Targeting/Trafficking of BK Channels to the Plasma Membrane
5 Proteins that Affect the Localization of BK Channels to Specific Plasma Membrane Compartments
6 Proteins that Mediate the Removal or Degradation of BK Channels: Dynamin-1
7 Proteins that Alter Channel Function
8 Examples of BK Channel Interactomes
9 Discussion
Acknowledgments
Chapter Five: Functional Role of Mitochondrial and Nuclear BK Channels
Abstract
1 Mitochondrial BK Channels
2 Nuclear BK Channels
3 Summary and Future Perspectives
Acknowledgments
Chapter Six: Modulation of BK Channels by Small Endogenous Molecules and Pharmaceutical Channel Openers
Abstract
1 Introduction
2 Salient Features of the BK Channel
3 Classification of Modulators by Their Mode of Action
4 Modulation of “N”
5 Modulation of “i(Vm)”
6 Modulation of Open Probability
7 G(Vm) Changes by Modulators with Different Modes of Action
8 Intrinsic Behavior of the Ion Conduction Gate
9 Voltage-Sensor Domain Function
10 Coupling Between the Ion Conduction Gate and VSDs
11 Ca2 + Sensors
12 Coupling Between the Ion Conduction Gate and Ca2 + Sensors
13 Coupling Between the VSDs and Ca2 + Sensors
14 Multistep Interactions
15 Modulators with Well-Characterized Mechanisms of Action
16 Modulators Whose Mechanisms Can Be Inferred
17 Modulators with an Unknown Mode of Action
18 Structural Bases of Modulatory Action
19 Importance of Mechanistic Information
20 Summary and Future Outlook
Acknowledgments
Chapter Seven: Modulation of BK Channels by Ethanol
Abstract
1 Introduction: Is the BK Channel an Ethanol Receptor?
2 Responses of Native BK Channels to Clinically Relevant Ethanol Concentrations in Ethanol-Naïve Systems
3 Molecular Determinants of Changes in BK Channel Steady-State Activity Evoked by Clinically Relevant Ethanol Concentrations in Ethanol-Naïve Systems
4 Adaptations in BK Channel/Coding Genes to Protracted or Repeated Ethanol Exposure: From Molecular Mechanisms to Modification of Ethanol-Induced Perturbation of Behavior
5 Conclusions
Acknowledgment
Chapter Eight: BK Channels in the Central Nervous System
Abstract
1 Overview
2 Expression Patterns of BK Channel Subunits in the CNS
3 Role of BK Channels in CNS Cellular Physiology
4 Role of BK Channels in CNS Function and Pathologies
5 Conclusions
Acknowledgments
Chapter Nine: BK Channels and the Control of the Pituitary
Abstract
1 Overview and Anatomy of the Pituitary Gland
2 Electrical Excitability of Anterior Pituitary Cells
3 Paradoxical Role of BK Channels and Bursting
4 BK Channels in Hypothalamic Neurons Regulating the Pituitary
5 Aims and Challenges for Understanding the Role of BK Channels in the Pituitary
Acknowledgments
Chapter Ten: BK Channels in the Vertebrate Inner Ear
Abstract
1 Introduction to the Auditory Periphery
2 BK Channel Structure and Function in Nonmammalian Auditory Organs
3 BK Channels in the Mammalian Cochlea
4 Conclusion
Chapter Eleven: BK Channels in the Vascular System
Abstract
1 Introduction
2 BK Channels in Vascular Smooth Muscle
3 Vascular Regulation by BK Channels
4 Regulation of Neurogenic Tone by BK Channels
5 Vascular Pathology Caused by BK Channel Dysregulation
Chapter Twelve: Developing Molecular Pharmacology of BK Channels for Therapeutic Benefit
Abstract
1 Potential Therapeutic Benefits of Targeting BK Channels
2 Issues Facing the BK Channel as a Drug Target
3 Natural Product Screening as a Way to Develop Molecular Pharmacology of BK Channels
4 Discovery of Small Molecule BK Channel Agonists
5 Identification of Potent and Selective Small Molecule BK Channel Inhibitors
6 Conclusions
Acknowledgments
Index
Contents of Recent Volumes
No. of pages: 550
Language: English
Edition: 1
Volume: 128
Published: May 26, 2016
Imprint: Academic Press
Hardback ISBN: 9780128036198
eBook ISBN: 9780128036471
CC
Candice Contet
Candice Contet, Ph.D., is Assistant Professor at The Scripps Research Institute (TSRI), La Jolla, CA. She is an NIH-funded investigator with 15 years of experience in the study of drug addiction. She is a member of the Integrative Neuroscience Initiative on Alcoholism (INIA-WEST) consortium funded by NIAAA, and directs the Viral Vector Core of TSRI Alcohol Research Center. She has a documented track record of investigating the molecular changes elicited by drugs of abuse and their relevance to behavioral adaptations. She has authored more than 20 peer-reviewed publications. She is on the editorial board of the journal Frontiers in Molecular Neuroscience. She attended the Ecole Normale Superieure (Paris, France) and obtained her PhD from the University of Strasbourg (France). She completed her research training under the mentoring of Drs. Nick Rawlins, Brigitte Kieffer, Athina Markou and George Koob.