Biflavanoids - 1st Edition - ISBN: 9780081010303


1st Edition

Chemical and Pharmacological Aspects

Authors: Shabir Hussain Lone Mohd Akbar Khuroo
Paperback ISBN: 9780081010303
Imprint: Elsevier
Published Date: 28th April 2016
Page Count: 52


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Biflavanoids are an important class of plant metabolites offering a range of activities, good availability and relatively low toxicity. Long thought to hold possible therapeutic potential, the recent surge in interest for natural product drug discovery has further highlighted the possibility of using them in the discovery of new drugs, and Biflavanoids: Chemical and Pharmacological Aspects provides a quick reference to the area in a focused manner, to support and encourage further research.

Beginning with a focus on the structural features and occurrence of biflavanoids, Chapter 1 reviews key background information including notes on nomenclature and natural distribution. Chapter 2 then goes on to discuss methods for identification and isolation, with separation and purification using various chromatography methods reviewed, followed by identification via UV spectroscopy, NRM spectroscopy and mass spectrometry. Synthesis is the focus of Chapter 3, with a broad range of synthetic methods outlined, before the book concludes in Chapter 4 by describing the biochemical pharmacology of Biflavanoids and their anticancer, antimicrobial, antiviral, anti-inflammatory and analgesic activity.

With its discussion of both the underlying chemistry and biological activity of Biflavanoids, Biflavanoids: Chemical and Pharmacological Aspects is a concise guide to this important class of compounds for all those working in the fields of medicinal chemistry and natural products drug discovery.

Key Features

  • Focused coverage of techniques for the isolation, identification, and synthesis of Biflavanoids
  • Practical tool for researchers working with these flavonoid compounds
  • Real-world expertise from the authors provides support for further developments in the growing field of natural product drug discovery
  • Useful, clear illustrations of key structures throughout the text


The book is intended to draw the widespread attention of drug discovery researchers/ scientists, particularly medicinal chemists, natural product chemists, pharmaceutical scientists and bioorganic chemists. Will also be useful for those studying and teaching advanced academic courses in natural products and medicinal chemistry

Table of Contents

  • Chapter 1. Structural Features and Occurrence of Biflavanoids
    • Abstract
    • 1.1 Introduction
    • 1.2 Nomenclature of Biflavanoids
    • 1.3 Structures of Biflavanoids
    • 1.4 Natural Distribution of Biflavanoids
    • 1.5 Conclusion
    • References
  • Chapter 2. Isolation and Identification of Biflavanoids
    • Abstract
    • 2.1 Introduction
    • 2.2 Separation and Purification
    • 2.3 Identification
    • 2.4 Conclusion
    • References
  • Chapter 3. Synthesis of Biflavanoids
    • Abstract
    • 3.1 Ullmann Coupling of Halogenated Flavones
    • 3.2 Synthesis of Biflavones via 1,1′-Biphenyls
    • 3.3 Metal-Catalyzed Cross-Coupling of Flavones
    • 3.4 Wessely–Moser Rearrangements
    • 3.5 Phenol Oxidative Coupling of Flavones
    • 3.6 Ullmann Condensation With Flavone Salts
    • 3.7 Nucleophilic Substitution
    • 3.8 Dehydrogenation of Biflavanones Into Biflavones
    • 3.9 Hydrogenation of Biflavone Into Biflavanone
    • 3.10 Special Approaches for the Synthesis of Selective Biflavanoids
    • 3.11 Conclusion
    • References
  • Chapter 4. Biochemical Pharmacology of Biflavanoids
    • Abstract
    • 4.1 General Biological Properties of Biflavanoids
    • 4.2 Anticancer Action of Bioflavonoids
    • 4.3 Antimicrobial and Antiviral Activity of Bioflavonoids
    • 4.4 Antiinflammatory Activity of Bioflavonoids: Cellular Mechanisms of Antiinflammatory Bioflavonoids
    • 4.5 Analgesic Activity of Bioflavonoids
    • 4.6 Antiinflammatory Activity of Synthetic Flavanoids
    • 4.7 Conclusion
    • References


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© Elsevier 2016
Paperback ISBN:

About the Author

Shabir Hussain Lone

Dr. Lone is a researcher at the Indian Institute of Integrative Medicine, India. His work, which has appeared in a number of top journals, is predominantly based on the discovery of bioactive compounds from natural products for drug development using a broad range of both classical and novel techniques.

Affiliations and Expertise

Indian Institute of Integrative Medicine, India

Mohd Akbar Khuroo

Mohd Akbar Khuroo is Senior Associate Professor for the Department of Chemisty and Coordinator of the Department of Science and Technology at the University of Kashmir, India. He has 22 publications to his name across a number of top journals, with a particular focus on collaborations with US institutes (including the universities of Mississippi, Pittsburg and Texas-Pan American). He is also co-author of two books with Dr Lone due to publish/published respectively with Springer and Lambert Academic Publishing. His research interests include drug discovery from natural products, with particular focus on structure based drug design, synthesis and biological evaluation of the natural products with high therapeutic potential

Affiliations and Expertise

University of Kashmir, India