Bidirectional Gene Promoters

Bidirectional Gene Promoters

1st Edition - September 1, 2022

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  • Editors: Fumiaki Uchiumi, Satoru Miyazaki
  • Paperback ISBN: 9780128187876

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Description

Recent studies in human genetics and in silico analyses have revealed that a number of genes are head-head orientated with other genes or non-coding RNAs. The expression of regulatory element-containing 5’-upstream regions of gene pairs are referred to as bi-directional promoters and are thought to have a key role in biological regulatory mechanisms. For example, tumor suppressor protein-encoding TP53 and BRCA1 genes are head-head bound with WRAP53 and NBR2, respectively. DNA-repair factor-encoding ATM and PRKDC (DNA-PKcs) genes have bidirectional partner NPAT and MCM4, respectively. Surveillance of the human DNA database has revealed that the numbers of DNA repair/mitochondrial function/immune response-associated genes are bound with other genes that are transcribed to opposite direction. The observations may encourage us to investigate in the molecular mechanisms how DNA repair/mitochondrial function/immune response-associated genes are regulated by bidirectional promoters. Not only protein-coding genes, but also quite a few ncRNAs, which play important roles in various cellular events, are transcribed under the regulation of the bidirectional promoters. More importantly, we know that dysregulation in the promoter activity and transcription initiation of genes might cause human diseases.

Key Features

  • Provides an overview of the process of transcription
  • Explains why there so many bidirectional promoters present in human genomes
  • Covers how the diverse biological functions of (non-coding RNAs) ncRNAs are controlled

Readership

Basic scientists and clinical or medicinal scientists who are investigating transcriptional regulation in mammalian cells

Table of Contents

  • 1. Introductory Chapter
    DNA replication and transcription

    Section I. Biological significances of the bidirectional transcription in eukaryotic cells

    2. Mitochondrial function and immune response factor encoding gene promoters
    3. DNA replication and repair factor-encoding gene promoters
    4. Regulation of miRNA and lncRNA promoters
    5. Parameters that determine direction of transcription

    Section II. Control of bidirectional promoters and the relevance to human diseases

    6. Dysregulation of transcription from bi-directional promoters
    7. Regulation of cell proliferation by transcription of the bi-directional promoter driven genes

    Section III. In silico and bioinformatic studies in gene expression system

    8. The distal transcriptional enhancers and repressors of bi-directional promoters
    9. Bioinformatic analysis and landscape of the human genome
    10. Application of the bioinformatics on therapeutics of human diseases

    Section IV. Evolution of transcription system in eukaryotic cells
     
    11.  Retrotransposons and transposable elements that contributed to evolution of transcription regulatory elements
    12. Molecular mechanisms that have brought bidirectional gene promoters

Product details

  • No. of pages: 210
  • Language: English
  • Copyright: © Elsevier 2022
  • Published: September 1, 2022
  • Imprint: Elsevier
  • Paperback ISBN: 9780128187876

About the Editors

Fumiaki Uchiumi

Professor Uchiumi received his Bachelor's degree (Chemistry) from Tokyo University of Science in 1987. In 1993, after obtaining his Ph.D. degree (Molecular Biology) from Tokyo University, he joined Professor S. Tanuma's Laboratory at Tokyo University of Science as an Assistant Professor. He obtained his second Ph.D. (Pharmaceutical Science) from Tokyo University of Science in 1999 and in 2000 was promoted to the position of Lecturer at Tokyo University of Science. Professor Uchiumi then went abroad as a post-doctoral researcher for the United States-Japan Cooperative Cancer Research Program in Professor E. Fanning’s Laboratory at Vanderbilt University, 2000-2001. Professor Uchiumi was promoted to Associate Professor and then Full Professor at Tokyo University of Science in 2010 and 2016, respectively.

Affiliations and Expertise

Professor of Pharmaceutical Sciences, Tokyo University of Science, Japan

Satoru Miyazaki

Professor Satoru Miyazaki’s key area of research is genome biology (Bioinformatics, databases).

Affiliations and Expertise

Department of Biochemistry, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Japan

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