Best Synthetic Methods: Organophosphorus (V) Chemistry

1st Edition

Authors: Chris Timperley
Hardcover ISBN: 9780080982120
eBook ISBN: 9780080982243
Imprint: Academic Press
Published Date: 4th December 2014
Page Count: 786
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Best Synthetic Methods: ORGANOPHOSPHORUS (V) CHEMISTRY provides systematic coverage of the most common classes of pentavalent organophosphorus compounds and reagents (including phosphonyl, phosphoryl, and organophosphates), and allows researchers an easy point of entry into this complex and economically important field. The book follows the Best Synthetic Methods format, containing practical methods, synthetic tips, and shortcuts. Where relevant, articles include toxicity data and historical context for the reactions. Typical analytical and spectroscopic data are also presented to enable scientists to identify key compound characteristics.

The book is a valuable companion to research chemists in both academia and industry, summarizing the best practical methods (often originating in difficult-to-access, foreign-language primary literature) in one place. It is ideally suited for those working on industrial applications of these compounds, including insecticides, herbicides, flame retardants, and plasticizers.

Key Features

  • Includes a mixture of tried and tested, historical methods that are proven to work, alongside new methods to provide scientists with a quick, time-saving resource of reliable methods
  • Includes tips and tricks to get reactions to work; important information often missing from other sources
  • Includes key analytical data for compounds, so scientists have one handy resource to select, perform, and analyze the best reaction


post graduates, postdocs and researchers in chemistry, engineering and materials science

Table of Contents

  • Preface
  • Chapter 1. General Overview

    • 1.1. Introduction
    • 1.2. Natural Occurrence of Phosphorus
    • 1.3. Principal Compounds of Phosphorus
    • 1.4. Phosphorus Compounds in Living Systems
    • 1.5. A Brief History of Synthetic Organophosphorus Chemistry
    • 1.6. Nomenclature of Organophosphorus Compounds
    • 1.7. Chiral Phosphorus Compounds and Biological Implications
    • 1.8. Phosphorus-Containing Pharmaceuticals
    • 1.9. Fire Retardants and Fire-Extinguishing Compounds
    • 1.10. Toxicology and Medical Treatment of organophosphorus Compounds
    • 1.11. Fluorogenic Nerve Agent Mimics for Screening for Improved Bioscavengers
    • 1.12. Biotinylated Nerve Agent Mimics for Activity-Based Enzyme Profiling
    • 1.13. Working Safely with Organophosphorus Compounds
  • Chapter 2. Phosphonyl Compounds

    • 2.1. Introduction
    • 2.2. Alkyl Alkyl-H-Phosphinates R(R′O)P(O)H
    • 2.3. Alkylphosphonic Dichlorides RP(O)Cl2
    • 2.4. Alkylphosphonic Dibromides RP(O)Br2
    • 2.5. Alkylphosphonic Difluorides RP(O)F2
    • 2.6. Alkylphosphonofluoridic Acids RP(O)(OH)F
    • 2.7. Alkylphosphonic Chlorofluorides RP(O)CIF
    • 2.8. Alkylphosphonic Isocyanatofluorides RP(O)(NCO)F
    • 2.9. Alkylphosphonic Isothiocyanatofluorides RP(O)(NCS)F
    • 2.10. Alkylphosphonic Diisocyanates RP(O)(NCO)2
    • 2.11. Alkylphosphonic Diisothiocyanates RP(O)(NCS)2
    • 2.12. Alkylphosphonic Acids RP(O)(OH)2
    • 2.13. Dialkyl Alkylphosphonates RP(O)(OR)2
    • 2.14. Dialkyl Arylphosphonates ArP(O)(OR)2
    • 2.15. Dialkyl α-Ketophosphonates (RO)2P(O)C(O)R′
    • 2.16. Dialkyl α-Hydroxyphosphonates (RO)2P(O)CH(OH)R′ (Pudovik Reaction)
    • 2.17. Dialkyl α-Siloxypho


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About the Author

Chris Timperley

Affiliations and Expertise

Defence Science and Technology Laboratory (Dstl), Porton Down, Wiltshire, UK