Basic Science in Obstetrics and Gynaecology

A Textbook for MRCOG Part 1

5th Edition - December 26, 2022
Authors: Phillip Bennett, Catherine Williamson, Lynne Sykes, David A MacIntyre, Peter H Dixon
Language: English
Paperback ISBN:
9 7 8 - 0 - 7 0 2 0 - 7 4 2 2 - 6
eBook ISBN:
9 7 8 - 0 - 7 0 2 0 - 7 4 2 1 - 9

Basic Science in Obstetrics and Gynaecology is an essential one-stop, portable revision tool for candidates preparing for Part 1 of the MRCOG specialist examination. Fully updated… Read more

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Basic Science in Obstetrics and Gynaecology is an essential one-stop, portable revision tool for candidates preparing for Part 1 of the MRCOG specialist examination.

Fully updated by experts who are internationally recognised in their fields, the chapters match the syllabus of the exam, combining detailed coverage of the science with related self-assessment questions that you will encounter in the MRCOG.

This book is suitable for doctors specialising in obstetrics and gynaecology who want the best chance possible to pass this difficult exam.

Cover image
Title page
Table of Contents
Any screen, Any time, Anywhere
Copyright
Preface
Contributors
Acknowledgements
1. Structure and Function of the Genome
Chapter outline
Chromosomes
Gene Structure and Function
The Central Dogma of Molecular Biology
Epigenetics
Mitochondrial DNA
Studying DNA
Molecular Biology Techniques
The ‘Postgenomic’ Era
The Molecular Basis of Inherited Disease – DNA Mutations
2. Clinical Genetics
Chapter outline
Chromosome Abnormalities
Single Gene Disorders
Multifactorial Inheritance
Genetic Testing and Interpretation of a Genetic Result
3. Embryology
Chapter outline
Oogenesis and Spermatogenesis
Development of the Genital Organs
Development of the Placenta
Development of Membranes and Formation of Amniotic Fluid
4. Fetal and Placental Physiology
Chapter Outline
Introduction
Fetal Development and Preparation for Birth
Placental Growth and Development
Fetal Growth and Growth Restriction
References
5. Applied Anatomy
Chapter outline
Introduction
Body Tissues and Cells
The Nervous System
Anatomy of the Brain
The Lymphatic System
The Vascular System
The Arterial System
The Venous System
The Musculoskeletal System
The Fetal Skull
Relevant Regional Anatomy of the Thorax
The Abdomen
The Liver
The Alimentary Tract
Retroperitoneal Organs
The Urinary Tract
The Pelvis
The Perineum
The Ischiorectal Fossae (Fig. 5.25)
Lateral Pelvic Wall
Pelvic Organs
The Rectum
The Anal Canal
The Bladder
The Breast
6. Pathology
Chapter outline
General Pathological Principles
Cellular Injury and Death
Pathology of Gynaecological Tumours
Pathology of Miscarriage and Gestational Trophoblastic Disease
Pathology of Common Congenital Abnormalities and Teratogenesis
Pathology of the Placenta
7. Microbiology and Virology
Chapter outline
Bacteriology, Mycology and Parasitology
Laboratory Identification
Bacteria and Disease
Killing Bacteria
Mycology
Parasites
Virology
Viral Nucleic Acid
Viruses of Importance in Obstetrics and Gynaecology
References
8. Immunology
Chapter outline
Introduction
The Immune System
Adaptive Immune Systems
Cells of the Innate Immune System
Regulation of the Immune System
The Fetus as an Allograft
Conclusion
9. Biochemistry
Chapter outline
Structure and Function of the Normal Cell
Proteins, Peptides and Amino Acids
Metabolism
Catabolism
Enzymes
Cell Signalling and Second Messaging
Biochemistry Exam Notes
10. Physiology
Chapter Outline
Biophysical Definitions
Distribution of Water and Electrolytes
Cellular Transport Mechanisms
Acid–Base Balance
Cardiovascular System
Endothelium in Pregnancy
Respiration
Urinary System
Gastrointestinal Tract
Liver
Nervous System
Blood
References
11. Endocrinology
Chapter Outline
Introduction
Mechanisms of Hormone Action and Second Messenger Systems
Hormone Types
Hypothalamus and Pituitary
Pineal Gland
Reproductive Hormones
Puberty
Leptin
Pregnancy
Menopause
Growth
Pancreas
Thyroid
Adrenal Gland
Calcium Homeostasis
12. Drugs and Drug Therapy
Chapter outline
Introduction
Language of Clinical Pharmacy
Factors that Influence Drug Action
Physiological Changes that Affect Drug Metabolism in Pregnancy
The Placental Barrier
Some Commonly Used Drugs
Psychotropic Drugs
Oral Contraceptives
Mechanism of Action of the Combined Pill
Drugs of Choice in Breastfeeding
Conclusion
13. Physics in Obstetrics and Gynaecology
Chapter Contents
Introduction
Physics for Surgery
Laser
Imaging
Ionising Radiation
Nuclear Medicine
Ultrasound
14. Statistics and Evidence-Based Healthcare
Chapter Outline
Introduction
Some Basic Statistical Principles
Primary and Secondary Outcomes
Data Types, Distribution Assumptions and Parametric Tests
Data Collection and Presentation
Measures of Outcome, Exposure and Effect
Equations for Basic Power Calculations
Acknowledgement
Recommended Statistics Texts
15. Clinical Research Methodology
Chapter outline
Introduction
Types of Clinical Investigation
The Clinical Research Process
Registration of Trials
Data
Consent, Information and Sponsors
Trial Steering Committees and Data Monitoring and Ethics Committees
Review of the Literature
Amendments and Reports
Promoting and Maintaining a Trial
Common Statistical Terms Used in Clinical Trials
References
Useful Sources of Information
16. Self-Assessment
Chapter Outline
Chapter 1: Structure and Function of the Genome Questions
Chapter 2: Clinical Genetics Questions
Chapter 3: Embryology Questions
Chapter 4: Fetal and Placental Physiology Questions
Chapter 5: Applied Anatomy Questions
Chapter 6: Pathology Questions
Chapter 7: Microbiology and Virology Questions
Chapter 8: Immunology Questions
Chapter 9: Biochemistry Questions
Chapter 10: Physiology Questions
Chapter 11: Endocrinology Questions
Chapter 12: Drugs and Drug Therapy Questions
Chapter 13: Physics in Obstetrics and Gynaecology Questions
Chapter 14: Statistics and Evidence-Based Health Care Questions
Chapter 15: Clinical Research Methodology Questions
Mock Exam Papers
Answers
Index

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Phillip Bennett

Catherine Williamson