Basic Principles in Nucleic Acid Chemistry V1 - 1st Edition - ISBN: 9780127019017, 9780323144001

Basic Principles in Nucleic Acid Chemistry V1

1st Edition

Editors: Paul O.P. Ts'o
eBook ISBN: 9780323144001
Imprint: Academic Press
Published Date: 1st January 1974
Page Count: 648
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Basic Principles in Nucleic Acid Chemistry, Volume I provides information pertinent to the fundamental aspects of nucleic acids. This book discusses the development of the basic principles in nucleic acid research that will serve as a foundation for further advancement in nucleic acid research.

Organized into six chapters, this volume begins with an overview of the history of the scientific study of nucleic acid as a genetic material. This text then examines the utility of the analogs of the naturally occurring nucleic acid components as biochemical tools and as therapeutic agents. Other chapters consider mass spectrometry that deals with the production and chemistry of ions in the vapor phase. This book discusses as well the various aspects of the excited states of the nucleic acids. The final chapter deals with the systematic study of the physiochemical properties of the monomeric units of nucleic acid.

This book is a valuable resource for molecular biologists, scientists, and research workers.

Table of Contents

List of Contributors


Contents of Other Volumes

1. In the Beginning

I. The Beginning of the Scientific Investigation of Nucleic Acid

II. The Beginning of the Formation of Nucleic Acid as Genetic Material and its Progressive Change Reflected in the Evolution of the Biological Kingdom

III. The Beginning of the Influence of Nucleic Acid Research on the Future of Man—"Intelligent" Evolution


2. Chemical Syntheses and Transformations of Nucleosides

I. Introduction

II. Synthesis of Nucleosides

III. Chemical Transformation of the Sugar Moieties of Nucleosides

IV. Chemical Transformations of the Heterocyclic Base Moieties of Nucleosides

V. Chemical Transformations That Involve both the Sugar and the Heterocyclic Base

3. Mass Spectrometry

I. Introduction

II. Production of Mass Spectra

III. Mass Spectra of Purine and Pyrimidine Bases

IV. Nucleosides and their Derivatives

V. Applications of Mass Spectrometry to Nucleotides

VI. Experimental Note


4. Excited States of Nucleic Acids

I. Introduction

II. Summary of Molecular Electronic Excited States

III. Excited States of Nucleotides

IV. Luminescence of Nucleotides as a Probe: The Y Base in tRNA

V. Interacting Chromophores

VI. Excited Polynucleotides

VII. Excited State Precursors for Photoproducts


5. Infrared and Raman Spectroscopy

I. Introduction

II. Vibrations in Nucleic Acids

III. Infrared Spectra of Nucleic Acids

IV. Raman Spectra of Nucleic Acids


6. Bases, Nucleosides, and Nucleotides

I. Structure, Configuration, Conformation, and Other Intrinsic Properties

II. Interaction of the Monomers


Author Index

Subject Index


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© Academic Press 1974
Academic Press
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About the Editor

Paul O.P. Ts'o

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