Basic Pharmacology

Basic Pharmacology

3rd Edition - October 28, 1991

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  • Editor: R W Foster
  • eBook ISBN: 9781483142029

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Description

Basic Pharmacology, Third Edition aims to present accounts of drug actions and their mechanisms in a compact, inexpensive, and updated form, and explain the basis of the therapeutic exploitation of drugs. This book is divided into sections that follow a particular theme and is introduced by the relevant pharmacological general principles. In each section, the major groups of drugs related to the theme are discussed with detailed expositions of the important “type” substances. Drugs of lesser importance are placed in proper context. A list of abbreviations that are referenced throughout the book is provided after the introduction. An index is also included at the end. This edition is designed to help students taking pharmacology, including medical students of subjects affiliated to medicine, to appreciate the rationale underlying the uses of drugs in therapeutics.

Table of Contents


  • Preface

    Introduction

    List of Abbreviations

    1 General Pharmacology

    Mechanisms of Drug Action

    Receptor Mediation of Drug Effects

    Adverse Effects of Drugs

    Allergically Determined Hypersensitivity to Drugs

    Genetically Determined Idiosyncracy to Drugs (Pharmacogenetics)

    Developmental Toxicity

    Adverse Drug Interactions

    Abuse of Drugs

    Drug Design, Development and Testing

    2 Drug Action on Peripheral Excitable Tissues - Drugs Acting on Signaling and Transduction Mechanisms Directly Related to Receptors for the Neurotransmitters Acetylcholine and Noradrenaline

    The Efferent Peripheral Nervous System

    The Effector Cells Innervated By Postganglionic Autonomic Neurones

    The Pharmacology of Cholinergic Axons and Their Terminals

    The Pharmacology of the Cholinoceptors of Skeletal Muscle

    The Pharmacology of the Cholinoceptors of Ganglia

    The Pharmacology of the Cholinoceptors of Smooth Muscle, Cardiac Muscle and Exocrine Glands

    Cholinesterases and Their Inhibitors

    Noradrenergic Neuroeffector Transmission as Target of Drug Action

    Drugs with Noradrenergic Prejunctional Sites of Action

    Drugs That Modify the Release of Noradrenaline

    Drugs That Modify the Inactivation of Noradrenaline

    Agonists at Adrenoceptors

    Antagonists at Adrenoceptors

    The Adrenal Medulla

    3 Drug Action on Peripheral Tissues - Drugs Acting on Signaling and Transduction Mechanisms Other than Those Directly Related to Receptors for Neurotransmitters and Hormones

    Local Anaesthesia

    Cardiac Antidysrhythmic Drugs

    Cardiac Glycosides

    Calcium Channel Blockers

    Methylxanthines

    Nitrates

    Diuretics

    Anticoagulant, Antithrombotic and Fibrinolytic Compounds

    Lipid-Lowering Drugs

    4 Endocrine Pharmacology

    Hypothalamo-Pituitary Axis

    Gonadotrophins

    Oestrogens, Progestogens and Androgens

    The Thyroid Gland and Drugs Used in Thyroid Abnormalities

    The Adrenal Cortex and the Corticosteroids

    Drugs in Diabetes Mellitus

    Posterior Pituitary Hormones

    Angiotensin

    Local Hormones

    Inflammation

    5 Drug Action on the Central Nervous System

    Chemical Transmission in the CNS

    Extrapyramidal Disorders of Movement

    Antidepressive Drugs

    Antipsychotic Drugs

    Vomiting, Emetics and Antiemetics

    Opioid Analgesics and Their Antagonists

    Stimulants and Hallucinogens

    Antipyretic Analgesics

    The State of Consciousness and the General Anaesthetic Agents

    6 Antiparasitic Chemotherapy

    Biochemical Selectivity

    Distributional Selectivity

    Drug Resistance in Parasites

    Chemotherapy of Metazoal Infestations

    Chemotherapy of Protozoal Infections

    Chemotherapy of Fungal Infections

    Chemotherapy of Bacterial Infections

    Chemotherapy of Viral Infections

    Chemotherapy of Malignant Neoplasms

    7 Drug Disposition

    Absorption

    Distribution

    Elimination

    Pharmacokinetics

    Drug Dosage Regimens

    Physicochemical Groupings of Drugs

    Water-Soluble Drugs

    Drugs with Intermediate Solubility

    Lipid-Soluble Drugs

    Acidic Drugs

    Basic Drugs

    8 Clinical Pharmacology

    Acute Poisoning

    Peptic Ulceration

    Inflammatory Bowel Disease

    Gastrointestinal Motility Disorders

    Congestive Heart Failure

    Hypertension and Antihypertensive Drugs

    Angina of Effort

    Asthma

    Coughs and Colds

    Headache and Migraine

    Drugs and Mental Disorders

    Epilepsy

    Drugs and Fertility

    Haematinic Drugs and the Cellular Elements of Blood

    Drugs in Joint Disease

    Drugs and the Skin

    Suggested Further Reading

    Index


Product details

  • No. of pages: 480
  • Language: English
  • Copyright: © Butterworth-Heinemann 1991
  • Published: October 28, 1991
  • Imprint: Butterworth-Heinemann
  • eBook ISBN: 9781483142029

About the Editor

R W Foster

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