Table of Contents

Part I: Cellular Neurochemistry and Neural Membranes
Cell Biology of the Nervous System
Cell Membrane Structures and Functions
Membrane Transport
Electrical Excitability and Ion Channels
Lipids
The Cytoskeleton of Neurons and Glia
Intracellular Trafficking
Axonal Transport
Cell Adhesion Molecules
Myelin Structure and Biochemistry
Energy Metabolism of the Brain

PART II: Intercellular Signaling
Synaptic Transmission and Cellular Signaling: An Overview
Acetylcholine
Catecholamines
Serotonin
Histamine
Glutamate and Glutamate Receptors
GABA
Purinergic Signaling
Peptides

PART III: Intracellular Signaling
G Proteins
Cyclic Nucleotides in the Nervous System
Phosphoinositides
Calcium
Serine and Threonine Phosphorylation
Tyrosine Phosphorylation
Transcription Factors in the Central Nervous System

PART IV: Growth, Development and Differentiation
Development of the Nervous System
Growth Factors
Stem Cells in the Nervous System
Formation and Maintenance of Myelin
Axonal Growth in the Adult Mammalian Nervous System

PART V: Cell Injury and Inflammation
Molecular Mechanisms and Consequences of Immune and Nervous System Reactions
Neuroinflammation
Brain Ischemia and Reperfusion: Cellular and Molecular Mechanisms in Stroke Injury
Lipid Mediators: Eicosanoids, Docosanoids and Platelet-Activating Factor
Apoptosis and Necrosis

PART VI: Inherited and Neurodegenerative Diseases
Peripheral Neuropathy
Diseases Involving Myelin
The Epilepsies: Phenotypes and Mechanisms
Genetics of Neurodegenerative Diseases
Disorders of Amino Acid Metabolism
Inborn Metabolic Defects of Lysosomes, Peroxisomes, Carbohydrates, and Fatty Acids and Mitochondria
Disorders of Muscle Excitability
Motor Neuro

Details

No. of pages:
1120
Language:
English
Copyright:
© 2012
Published:
Imprint:
Academic Press
Print ISBN:
9780123749475
Electronic ISBN:
9780080959016

About the authors

Scott Brady

Affiliations and Expertise

University of Illinois, Chicago IL

George Siegel

Affiliations and Expertise

Loyola University, Chicago, IL, USA

R. Wayne Albers

OBITUARY FOR R. WAYNE ALBERS, August 5, 1928 – September 28, 2013 R. Wayne Albers, Ph.D., Scientist Emeritus, Chief of Section on Enzyme Chemistry (retired), Laboratory of Neurochemistry in the NINDS, NIH, Bethesda, MD, is a world-recognized neuroscientist most noted for his research in the field of membrane cation transport and neuronal excitability in the nervous system. Dr. Albers and physiologist R.L. Post performed the principal experiments leading to their now widely-held Albers-Post model for the mechanism of the cation transport enzyme, sodium-potassium-activated ATPase. Dr. Albers was one of the founding co-editors of the comprehensive text, Basic Neurochemistry: Molecular, Cellular and Medical Aspects, first published in 1972, continuing as co-editor for 8 editions, the latest having been published in 2012. After receiving his PhD at Washington University School of Medicine in 1954, Dr. Albers embarked on a distinguished career of research at the NIH, being a founding investigator in the first Laboratory of Neurochemistry. Dr. Albers was one of the first members of the American Society for Neurochemistry at its inception, serving on its Council and its Committees on Publications and Education and on Electronic Publications. He has served as Professor of Biochemistry at George Washington University, Faculty Member of the NIH Foundation for Advanced Education in the Sciences, Associate Editor of the Journal of Neurochemistry and of Experimental Neurology, and on the editorial boards of several journals. Dr. Albers passed away on September 28, 2013. He was 85 years old and is survived by his former wife, Frances Albers, their children Gail Morrell, Belinda Caron and Patricia Steinhoff, 6 grandchildren, and 8 great-grandchildren. He also had a son, the late Jonathan Albers. Dr. Albers was considered a gentleman, an excellent scientific colleague with a keen intellect and friend by all who worked with him. He will be sorely missed, not only by h

Affiliations and Expertise

National Institutes of Health, Bethesda MD, USA

Donald Price

Affiliations and Expertise

The Johns Hopkins University School of Medicine, Baltimore MD