Basic Neurochemistry

8th Edition

Principles of Molecular, Cellular, and Medical Neurobiology

Editors: Scott Brady George Siegel R. Wayne Albers Donald Price
Hardcover ISBN: 9780123749475
eBook ISBN: 9780080959016
Imprint: Academic Press
Published Date: 7th December 2011
Page Count: 1120
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Basic Neurochemistry: Principles of Molecular, Cellular, and Medical Neurobiology, the outstanding and comprehensive classic text on neurochemistry, is now newly updated and revised in its Eighth Edition. For more than forty years, this text has been the worldwide standard for information on the biochemistry of the nervous system, serving as a resource for postgraduate trainees and teachers in neurology, psychiatry, and basic neuroscience, as well as for medical, graduate, and postgraduate students and instructors in the neurosciences. The text has evolved, as intended, with the science. It is also an excellent source of current information on basic biochemical and cellular processes in brain function and neurological diseases for continuing medical education and qualifying examinations. This text continues to be the standard reference and textbook for exploring the translational nature of neuroscience, bringing basic and clinical neuroscience together in one authoritative volume. Our book title reflects the expanded attention to these links between neurochemistry and neurologic disease.

This new edition continues to cover the basics of neurochemistry as in the earlier editions, along with expanded and additional coverage of new research from: Intracellular trafficking; Stem cells, adult neurogenesis, regeneration; Lipid messengers; Expanded coverage of all major neurodegenerative and psychiatric disorders; Neurochemistry of addiction; Neurochemistry of pain; Neurochemistry of hearing and balance; Neurobiology of learning and memory; Sleep; Myelin structure, development, and disease; Autism; and Neuroimmunology.

Key Features

  • Completely updated text with new authors and material, and many entirely new chapters
  • Over 400 fully revised figures in splendid color
  • 61 chapters covering the range of cellular, molecular and medical neuroscience
  • Translational science boxes emphasizing the connections between basic and clinical neuroscience
  • Companion website at


Advanced undergraduates, graduate students and post-docs in neuroscience or biomedical science, medical students, clinical neuroscientists and neurologists

Table of Contents

Associate Editors

List of Boxes


List of Contributors

Eighth Edition Acknowledgments and History

Preface to the Eighth Edition

Part I: Cellular Neurochemistry and Neural Membranes

Chapter 1. Cell Biology of the Nervous System


Cellular Neuroscience is the Foundation of Modern Neuroscience

Neurons: Common Elements and Diversity

Macroglia: More than Meets the Eye


Blood–Brain Barriers and the Nervous System

The Neurovascular Unit Includes Multiple Components



Chapter 2. Cell Membrane Structures and Functions

Phospholipid Bilayers

Membrane Proteins

Biological Membranes


Chapter 3. Membrane Transport


Primary Active Transport (P-Type) Pumps

Na,K-Adenosinetriphosphatase (Na,K-ATPase)

Ca Adenosinetriphosphatases and Na,Ca Antiporters

The Primary Plasma Membrane Ca Transporter (PMCA)

Smooth Endoplasmic Reticulum Calcium Pumps (SERCA)

Other P-Type Transporters

V0V1 Proton Pumps

ATP-Binding Cassettes

Secondary Active Transport

General Physiology of Neurotransmitter Uptake and Storage

The Cation Antiporters

The Anion Antiporters

Facilitated Diffusion: Aquaporins and Diffusion of Water

Facilitated Diffusion of Glucose and Myoinositol


Chapter 4. Electrical Excitability and Ion Channels

Membrane Potentials and Electrical Signals in Excitable Cells

Action Potentials in Electrically Excitable Cells

Functional Properties of Voltage-Gated Ion Channels

The Voltage-Gated Ion Channel Superfamily

The Molecular Basis for Ion Channel Function

Ion Channel Diversity



Chapter 5. Lipids



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About the Editor

Scott Brady

Affiliations and Expertise

University of Illinois, Chicago IL

George Siegel

Affiliations and Expertise

Loyola University, Chicago, IL, USA

R. Wayne Albers

OBITUARY FOR R. WAYNE ALBERS, August 5, 1928 – September 28, 2013 R. Wayne Albers, Ph.D., Scientist Emeritus, Chief of Section on Enzyme Chemistry (retired), Laboratory of Neurochemistry in the NINDS, NIH, Bethesda, MD, is a world-recognized neuroscientist most noted for his research in the field of membrane cation transport and neuronal excitability in the nervous system. Dr. Albers and physiologist R.L. Post performed the principal experiments leading to their now widely-held Albers-Post model for the mechanism of the cation transport enzyme, sodium-potassium-activated ATPase. Dr. Albers was one of the founding co-editors of the comprehensive text, Basic Neurochemistry: Molecular, Cellular and Medical Aspects, first published in 1972, continuing as co-editor for 8 editions, the latest having been published in 2012. After receiving his PhD at Washington University School of Medicine in 1954, Dr. Albers embarked on a distinguished career of research at the NIH, being a founding investigator in the first Laboratory of Neurochemistry. Dr. Albers was one of the first members of the American Society for Neurochemistry at its inception, serving on its Council and its Committees on Publications and Education and on Electronic Publications. He has served as Professor of Biochemistry at George Washington University, Faculty Member of the NIH Foundation for Advanced Education in the Sciences, Associate Editor of the Journal of Neurochemistry and of Experimental Neurology, and on the editorial boards of several journals. Dr. Albers passed away on September 28, 2013. He was 85 years old and is survived by his former wife, Frances Albers, their children Gail Morrell, Belinda Caron and Patricia Steinhoff, 6 grandchildren, and 8 great-grandchildren. He also had a son, the late Jonathan Albers. Dr. Albers was considered a gentleman, an excellent scientific colleague with a keen intellect and friend by all who worked with him. He will be sorely missed, not only by h

Affiliations and Expertise

National Institutes of Health, Bethesda MD, USA

Donald Price

Affiliations and Expertise

The Johns Hopkins University School of Medicine, Baltimore MD