Basic Immunology - 1st Edition - ISBN: 9780723602521, 9781483193304

Basic Immunology

1st Edition

Authors: E. R. Gold D. B. Peacock
eBook ISBN: 9781483193304
Imprint: Butterworth-Heinemann
Published Date: 1st January 1970
Page Count: 428
Tax/VAT will be calculated at check-out Price includes VAT (GST)
30% off
30% off
30% off
30% off
30% off
20% off
20% off
30% off
30% off
30% off
30% off
30% off
20% off
20% off
30% off
30% off
30% off
30% off
30% off
20% off
20% off
54.95
38.47
38.47
38.47
38.47
38.47
43.96
43.96
43.99
30.79
30.79
30.79
30.79
30.79
35.19
35.19
72.95
51.06
51.06
51.06
51.06
51.06
58.36
58.36
Unavailable
Price includes VAT (GST)
× DRM-Free

Easy - Download and start reading immediately. There’s no activation process to access eBooks; all eBooks are fully searchable, and enabled for copying, pasting, and printing.

Flexible - Read on multiple operating systems and devices. Easily read eBooks on smart phones, computers, or any eBook readers, including Kindle.

Open - Buy once, receive and download all available eBook formats, including PDF, EPUB, and Mobi (for Kindle).

Institutional Access

Secure Checkout

Personal information is secured with SSL technology.

Free Shipping

Free global shipping
No minimum order.

Description

Basic Immunology focuses on substances that take part in serological reactions, including antigens, antibodies, and the physicochemical nature of immunological reactions.

The selection first elaborates on the basic notions of immunity, antigens, immunoglobulins, and the production of antibody. Discussions focus on factors which increase the immune response, production of antibody, biological properties of immunoglobulins, evolution and control of immunoglobulin structure, antigenicity, specific immunity, and resistance. The text then takes a look at the complement system, antigen-antibody reactions, and immediate hypersensitivity.

The book ponders on cell-mediated immunity and delayed hypersensitivity, transplantation immunology, and tumor immunology. Topics include production of immunity to neoplasms, immunological aspects of carcinogenesis and growth of established tumors, immunotherapy for experimental neoplasms, donor selection in human-organ transplantation, elicitation of delayed hypersensitivity, and the role of humoral factors in the transfer of delayed hypersensitivity.

The selection is a valuable reference for medicine students and researchers interested in basic immunology.

Table of Contents


1. Basic Notions of Immunity

Introduction

Resistance

Specific Immunity

2. Antigens

Introduction

Antigenicity

Molecular Size

Chemical Structure

Chemical Composition

Specificity

Protein Antigens

Polysaccharide Antigens

Lipid Antigens

Heterophile Antigens

3. Immunoglobulins

Introduction

Pathological Immunoglobulins: Prototypes of Immunoglobulin Structure

Animal Immunoglobulins

General Structure

Detailed Structure and Antigen Composition

Structure of Light Chains

Structure of Heavy Chains

Subdivisions of Immunoglobulin Classes

Evolution and Control of Immunoglobulin Structure

Biological Properties of Immunoglobulins

The Whole Molecule

The Combining Site

4. The Production of Antibody

The Fate of Antigen

Production of Antibody

Natural Antibody

The Primary Response

The Secondary Response

Quantitative Aspects of Antibody Production

Cellular Aspects of Antibody Production

Factors Which Increase the Immune Response

Factors Which Depress the Immune Response

Summary and Conclusions

5. The Complement System

Introduction

Components of Complement

Mechanism of Immune Lysis

Other Biological Functions of Complement Components

Conglutinin

Deficiencies of Complement

6. Antigen-Antibody Reactions

Introduction

Mechanisms of Reactions

Forces involved

Thermodynamics and Kinetics

Secondary Reactions

Precipitation

Theories of Precipitation

Immunodiffusion and Immuno-Electrophoresis

Agglutination

Passive Agglutination

Passive Haemagglutination

Theories of Agglutination

Antigen-Antibody Reactions Involving Complement

Cross-Reactions

7. Immediate Hypersensitivity

Introduction

Anaphylaxis

Biochemical Mediators

Passive Cutaneous Anaphylaxis

Reagins

Blocking Antibodies

Anaphylatoxin

Arthus Reaction

Serum Sickness

Shwartzman Reaction

8. Cell-Mediated Immunity in Vitro Studies

Introduction

Macrophage Migration Inhibition

Summary

Lymphocyte Transformation

Non-Specific Stimulation

Transformation as a Specific Secondary Immune Response

Transformation as a Primary Immune Response

Summary

Specific Cell-Mediated Cytotoxicity in Vitro

Summary

9. Cell-Mediated Immunity and Delayed Hypersensitivity

Introduction

The Elicitation of Delayed Hypersensitivity

The Tuberculin Reaction and its Histology

Delayed Hypersensitivity to Other Antigens and its Histology

The Induction of Delayed Hypersensitivity

Inducing Antigens

The Role of the Skin and Lymph-Nodes

Antigenic Specificity in Delayed Hypersensitivity

Transfer of Delayed Hypersensitivity by Cells

The Role of Humoral Factors in the Transfer of Delayed Hypersensitivity

Antibody and Delayed Hypersensitivity

Macrophage Cytophilic Antibodies

High Affinity Antibodies

The Role of Antibody in Delayed Hypersensitivity

The Role of the Thymus in Delayed Hypersensitivity

Factors Affecting Delayed Hypersensitivity

Delayed Hypersensitivity and Immunity

10. Transplantation Immunology

Introduction

The Fate of Grafts

The Mechanism of the Homograft Reaction

Historical Aspects

Active Immunity

Factors Influencing the Intensity of the Homograft Reaction

Methods for Abrogating the Homograft Reaction

Specific Immunological Tolerance

Graft-Versus-Host Reactions

Chimaeras

Donor Selection in Human-Organ Transplantation

11. Tumour Immunology

Introduction

Transplantation of Tumours

Production of Immunity to Neoplasms

Immunological Enhancement

Tumour-Specific Antigens

Immunological Aspects of Carcinogenesis and the Growth of Established Tumours

Immunotherapy for Experimental Neoplasms

12. Auto-Immunity

Introduction

Causes of Auto-Immunization

Auto-Immunization Following Antigenic Stimulation

Auto-Immunization Due to Abnormality of the Immunological Apparatus

Experimental Auto-Immune Disease

Production of Auto-Immune Disease

Prevention of Experimental Auto-Immune Disease

The Spontaneous Auto-Immune Disease of New Zealand Black Mice

Mechanisms of Tissue Damage

Auto-Immunity and Disease in Man

The Auto-Immune Haemolytic Anaemias

Hashimoto's Thyroiditis and Related Conditions

Systemic Lupus Erythematosus

Glomerulonephritis

Ulcerative Colitis

Myasthenia Gravis and the Role of the Thymus in Auto-Immune Disease

Conclusions

Index

Details

No. of pages:
428
Language:
English
Copyright:
© Butterworth-Heinemann 1970
Published:
Imprint:
Butterworth-Heinemann
eBook ISBN:
9781483193304

About the Author

E. R. Gold

D. B. Peacock