Basic Biology and Clinical Impact of Immunosenescence - 1st Edition - ISBN: 9780444513168, 9780080546483

Basic Biology and Clinical Impact of Immunosenescence, Volume 13

1st Edition

Authors: G. Pawelec
eBook ISBN: 9780080546483
Hardcover ISBN: 9780444513168
Imprint: Elsevier Science
Published Date: 1st May 2003
Page Count: 322
Sales tax will be calculated at check-out Price includes VAT/GST
Price includes VAT/GST
× DRM-Free

Easy - Download and start reading immediately. There’s no activation process to access eBooks; all eBooks are fully searchable, and enabled for copying, pasting, and printing.

Flexible - Read on multiple operating systems and devices. Easily read eBooks on smart phones, computers, or any eBook readers, including Kindle.

Open - Buy once, receive and download all available eBook formats, including PDF, EPUB, and Mobi (for Kindle).

Institutional Access

Secure Checkout

Personal information is secured with SSL technology.

Free Shipping

Free global shipping
No minimum order.

Table of Contents

Preface. 1. The OCTO and NONA immune longitudinal studies: a review of 11 years' studies of Swedish very old humans (A. Wikby, B. Johansson, F. Ferguson). 2. Immune measures which predict nine-year survival in an elderly population sample (F. Huppert, E. Pinto et al.). 3. Immunological and immunogenetic markers of successful and unsuccessful ageing (G. Candore, G. Colonna-Romano et al.). 4. Developmental aspects of the thymus in ageing (A. Globerson). 5. Effective immunity during late life: a possible role for the thymus (J. Pindo-Lopez, R. Aspinall). 6. Alterations in signal transduction in T lymphocytes and neutrophils with ageing (T. Fulop, K. Hirokawa et al.). 7. CD28 downregulation and expression of NK-associated receptors on T cells in ageing and situations of chronic activation of the immune system (J. Casado, O. DelaRosa et al.). 8. Characterization of NK cells in the elderly (E. Mariani, A. Facchini). 9. T cell ageing and immune surveillance (J. McLeod). 10. A road to ruins: an insight into immunosenescence (S. Gupta). 11. Genetic damage and ageing T cells (O. Ross, M. Curran et al.). 12. Role of DNA-dependent protein kinase (DNA-PK), a protein with multiple intracellular functions, in cells of the ageing immune system (D. Frasca, L. Guidi, G. Doria). 13. Linker histone H1o gene expression during ageing and after the effect of histone deacetylase inhibitors in human diploid fibroblasts and T lymphocytes (T.G. Sourlingas, K.E. Sekeri-Pataryas). 14. Zinc and the immune system of elderly (K.-H. Ibs, P. Gabriel, L. Rink). 15. Altered zinc binding by metallothioneins in immune-neuroendocrine senescence: a vicious circle between metallothioneins and chaperones? (E. Mocchegiani, R. Giacconi et al.). 16. T cell exhaustion and ageing: Is replicative senescence relevant? (R.B. Effros). 17. Cultured T cell clones as models for immunosenescence (G. Pawelec).


Ageing is of perennial interest as a universal feature in all human societies. The genetic background and biochemical bases of ageing processes are currently being revealed in unprecedented detail. It is emerging that one of the main hurdles to be overcome in achieving a long and healthy lifespan is the maintenance of a properly functioning immune system. The main cause of death in people who have achieved "successful ageing" (which mostly means not having succumbed to cancer or cardiovascular disease) is infectious disease, caused by immunosenescence. This book contains chapters by many of the leaders in the field of immune-related issues in ageing and remediation.


No. of pages:
© Elsevier Science 2003
Elsevier Science
eBook ISBN:
Hardcover ISBN:

Ratings and Reviews

About the Authors

G. Pawelec Author

Affiliations and Expertise

Professor of Experimental Immunology, University of Tübingen, Center for Medical Research (ZMF), Waldhörnlestr. 22, D-72072, Germany