Bacterial Survival in the Hostile Environment

Bacterial Survival in the Hostile Environment

1st Edition - September 28, 2022

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  • Editors: Ashutosh Kumar, Shivendra Tenguria
  • Paperback ISBN: 9780323918060
  • eBook ISBN: 9780323972208

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Variety of bacteria are present in our environment but only a few of these bacteria causes diseases in their hosts including humans. These bacteria face different stresses in the environment as well as inside the host and adapt number of strategies for their survival. In 5 parts Bacterial Survival in the Hostile Environment covers all tactics and strategies adopted by bacteria for their survival under stressed conditions and will be focused on mechanistic insights of pathogenic adaptations to host environments (acidic environment, microaerobic conditions, immune system stress, metal stress etc., modulation of host pathways by pathogens for survival, dormancy, drug tolerance and resistance, proteins for stress survival). The content also includes different adaptation mechanisms of extremophiles to extreme environment, provides a complete and globally available advance knowledge related to bacterial survival from different perspectives and reviews the knowledge gaps and future prospects in the field of microbial adaptation for sustainable development of in the field of infection biology and pharmaceutics.

Key Features

  • Provides in depth knowledge about pathogen biology and microbial adaptations, microbe-host interactions, impact of pathogens on host physiology, virulent factors produced by pathogens and pharmaceutical applications, mechanism of pathogenic virulent factors
  • Covers all tactics and strategies adopted by bacteria for their survival under stressed conditions
  • Focuses on mechanistic insights of pathogenic adaptations to host
  • Includes different adaptation mechanisms of extremophiles to extreme environment


Researchers, Scientists, Microbiologists, Medical practitioners, Medical students, Biotechnologists, Bacteriologists and others in the field of infectious diseases; Industry professionals throughout the globe who aspire to work on the pathogen biology

Table of Contents

  • Part 1:
    1. Pathogenic adaptation to host environment
    2. Adaptation to acidic environment
    3. Microaerobic conditions
    4. Immune system stress
    5. Metal stress

    Part 2: Modulation of host pathways by pathogens for adaptation/survival
    6. Modulation in glycolytic flux
    7. Endoplasmic reticulum stress
    8. Host Mitochondria
    9. Apoptosis
    10. Necrosis
    11. Phagosome maturation
    12. Autophagy regulation

    Part 3: Dormancy, Drug Tolerance and Resistance
    13. Growth regulation by microbes
    14. Survival and reactivation strategies of pathogens in stress through heterogeneous population generation
    15. Persisters
    16. Antimicrobial resistance

    Part 4: Proteins for stress survival
    17. Chaperones
    18. Ribosome associated proteins
    19. Methyltransferases
    20. Proteins responsible for growth regulation of bacteria during unfavourable conditions
    21. Proteins involved in biofilm

    Part 5: Adaptation to Extreme Environment
    22. Adaptations to Ph
    23. Temperature
    24. Pressure
    25. Halophilic adaptations
    26. Radiation adaptation

Product details

  • Language: English
  • Copyright: © Academic Press 2022
  • Published: September 28, 2022
  • Imprint: Academic Press
  • Paperback ISBN: 9780323918060
  • eBook ISBN: 9780323972208

About the Editors

Ashutosh Kumar

Dr. Ashutosh Kumar received a MSc. degree (2008) in Biotechnology and Ph.D. degree (2013) in Biotechnology and Bioinformatics from University of Hyderabad, India. He did his postdoctoral research at TIFR-National Centre for Biological Sciences Bangalore. He also worked as Visiting Research Scientist at Robert Koch Institute Berlin and later selected for a research stay within the framework of International Research Training Group (GRK1673) “Functional Molecular Infection Epidemiology” He has made significant contributions to the study of virulence mechanisms and strategies of survival, adaptation and persistence of Mycobacterium tuberculosis. He was involved in identification of an enzyme from M. tuberculosis that promote biofilm formation and drugs that enhanced the potency of two current anti-tuberculosis antibiotics. He received many scholarships, awards and fellowship during his education. He has many publications in different International Journals and Books (Elsevier, Springer etc.) on various aspects of microbiology, biotechnology, pathogen biology covering his interests

Affiliations and Expertise

Assistant Professor, Department of Microbiology, Tripura University (A Central University), Agartala, Tripura, India

Shivendra Tenguria

Dr. Tenguria is an active researcher and currently working as Project Scientist in Cedars-Sinai Medical Center, Los Angeles, CA USA. He has been actively involved in research and training of graduate and undergraduate students. He received his MSc in Life Sciences from University of Rajasthan, Jaipur and PhD in Biotechnology from University of Hyderabad, Hyderabad, India. He received his postdoctoral training from Purdue University, Indiana, USA and Cedars-Sinai Medical Center (UCLA), Los Angeles, California, USA. Currently, he is working in the area of molecular innate immunity to unravel molecular signaling mechanics for sensing danger (infectious pathogens) signals through cytosolic receptors of the innate immune system of human and mouse hosts. With his doctoral and postdoctoral fellowships and research in the area of host-microbe interactions, bacterial survival and pathogenesis, he made seminal contributions by publishing in international Jr (Cell Host-Microbe, Nature Commun, Frontiers).

Affiliations and Expertise

Project Scientist, Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center (UCLA), Los Angeles, CA, United States

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