Bacterial Protein Toxins V2A

1st Edition - January 28, 1971
Author: Solomon Kadis
Language: English
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 1 5 0 5 1 - 4

Microbial Toxins, A Comprehensive Treatise, Volume IIA: Bacterial Protein Toxins provides a comprehensive discussion of various aspects of bacterial toxins. The book's 10 chapters… Read more

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Microbial Toxins, A Comprehensive Treatise, Volume IIA: Bacterial Protein Toxins provides a comprehensive discussion of various aspects of bacterial toxins. The book's 10 chapters discuss the following: botulinum toxin; tetanus toxin; Clostridium perfringens toxins types A, B, C, D, and E; cholera toxins; the exotoxin of Shigella dysenteriae; protein toxins from Bordetella pertussis; Salmonella typhimurium and Escherichia coli neurotoxins; toxins of Proteus mirabilis; and Listeria monocytogenes toxin. Each chapter covers the nature of the toxin, toxin production and purification, and mode of action.

List of Contributors

Preface

Contents of Other Volumes

1. Botulinum Toxin

I. The Disease

II. History

III. Requirements for Growth and Toxin Production

IV. Purification of the Toxin

V. Nature of Crystalline Toxin Type A

VI. Nature of Toxins of Other Types

VII. Spore Toxin

VIII. Hemagglutinins of Clostridium botulinum

IX. Activation Phenomenon

X. Effect of Proteolytic Enzymes on the Toxin

XI. Specific Chemical Groupings Involved in Toxicity

XII. Site of Action

XIII. Mode of Action of Botulinum Toxin

XIV. Botulism as an Infection

XV. Toxin as Antigen

XVI. Effects of Chemical and Physical Agents on the Toxin of CI. botulinum

XVII. Is Botulinum an Exotoxin

XVIII. Role of the Toxin in CI. botulinum

XIX. Laboratory Detection of Botulinum Toxin

XX. Conclusions

References

2. Tetanus Toxin

I. Introduction

II. Toxicity

III. Production and Purification

IV. Nature

V. Synthesis

VI. Mode of Action

VII. Immunology and Immunochemistry

VIII. Pathogenesis

References

3. Type A Clostridium perfringens Toxin

I. Introduction

II. Nature of the Toxin

III. Production of Clostridium perfringens Toxin

IV. Toxin Purification

V. Toxin Components

VI. Mechanism of Toxin Action

VII. Detoxification

VIII. Active Immunization against Gas Gangrene

References

4. Clostridium perfringens Toxins Types B, C, D, and E

I. Introduction

II. Toxicity

III. Production and Purification

IV. Nature

V. Action

VI. Immunology

VII. Pathogenesis

VIII. Toxin Assays

References

5. Cholera Toxins

I. Introduction

II. Pathophysiology and Morbid Anatomy of Cholera

III. Kinds of Cholera Toxins

IV. Cholera Toxins and Man

References

6. The Exotoxin of Shigella dysenteriae

I. Introduction

II. Toxicity

III. Production and Purification

IV. Nature

V. Synthesis

VI. Mode of Action

VII. Immunology

VIII. Pathogenesis

References

7. Protein Toxins from Bordetella pertussis

I. Introduction

II. Heat-Labile Toxin (HLT)

III. Histamine-Sensitizing Factor (HSF)

References

8. Salmonella typhimurium and Escherichia coli Neurotoxins

I. Introduction and History

II. Salmonella typhimurium Neurotoxin

III. Escherichia coli Neurotoxins

IV. Concluding Remarks

References

9. Toxins of Proteus mirabilis

I. Introduction

II. Toxicity

III. Production and Purification

IV. Nature

V. Action

VI. Immunology and Immunochemistry

VII. Pathogenesis

VIII. Summary

References

10. Listeria monocytogenes Toxin

I. Introduction

II. Manifestations of Toxemia Induced by Listeric Infection and Products of Listeria monocytogenes

III. Production, Purification, and Nature of Hemolysin

IV. Mode of Action of Listeria Hemolysin

V. Conclusions and Discussion

References

Author Index

Subject Index