How does a bacterial cell grow during the division cycle? This question is answered by the codeveloper of the Cooper-Helmstetter model of DNA replication. In a unique analysis of the bacterial division cycle, Cooper considers the major cell categories (cytoplasm, DNA, and cell surface) and presents a lucid description of bacterial growth during the division cycle. The concepts of bacterial physiology from Ole Maaløe's Copenhagen school are presented throughout the book and are applied to such topics as the origin of variability, the pattern of DNA segregation, and the principles underlying growth transitions. The results of research on E. coli are used to explain the division cycles of Caulobacter, Bacilli, Streptococci, and eukaryotes. Insightful reanalysis highlights significant similarities between these cells and E.coli. With over 25 years of experience in the study of the bacterial division cycle, Cooper has synthesized his ideas and research into an exciting presentation. He manages to write a comprehensive volume that will be of great interest to microbiologists, cell physiologists, cell and molecular biologists, researchers in cell-cycle studies, and mathematicians and engineering scientists interested in modeling cell growth.

Key Features

@introbul:Key Features @bul:* Written by one of the codiscoverers of the Cooper-Helmstetter model * Applies the results of research on E. coli to other groups, including Caulobacter, Bacilli, Streptococci, and eukaryotes; the Caulobacter reanalysis highlights significant similarities with the E. coli system * Presents a unified description of the bacterial division cycle with relevance to eukaryotic systems * Addresses the concepts of the Copenhagen School in a new and original way


Bacteriologists, microbiologists, cell biologists and physiologists, molecular biologists, and geneticists; students in advanced bacterial cell physiology courses

Table of Contents

Prologue. Bacterial Growth. A General Model of the Bacterial Division Cycle. Experimental Analysis of the Bacterial Division Cycle. Cytoplasm Synthesis during the Division Cycle. DNA Replication during the Bacterial Division Cycle. Synthesis of the Cell Surface during the Division Cycle. Density and Turgor during the Division Cycle. Variability of the Division Cycle. The Segregation of DNA and the Cell Surface. Transitions and the Bacterial Life Cycle. The Division Cycle of Caulobacter crescentus. Growth and Division of Streptococcus. Growth and Division of Bacillus. The Growth Law and Other Topics. The Eukaryotic Division Cycle. Conservation Laws of the Division Cycle. Epilogue. Bibliography. Author Index. Subject Index.


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© 1991
Academic Press
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Electronic ISBN:

About the author

Stephen Cooper

Affiliations and Expertise

University of Michigan Medical School


@qu:"Stephen Cooper, one of the most original and experienced workers in the field of bacterial growth and division, has written a book that is as unconventional as it is interesting. His thoughts are clear, presented in an engaging style, and accessible to all. There is something here for everyone." @source:--CELL @qu:"A particularly welcome addition that will be useful to researchers, teachers, and advanced students. This volume presents a comprehensive review of the experimental evidence concerning the cell division cycle at the level of the individual cell and its regulation. As such, it is a unique and useful companion to other recent books that focus on the broader physiological, genetic, and biochemical issues of bacterial growth and its regulation. This book is especially attractive because it presents a focused physiological and biochemical review of the fundamental bacterial division cycle. Much of the presentation is framed within the context of the Copenhagen school that has spawned so much exciting information on microbial physiology over the years. Many unique models are used to illustrate key concepts and mechanisms." @source:--ASM NEWS @qu:"Fascinating... opens the scientific windows on the understanding of an expert within a specialist field. A highly detailed and careful analysis of experiments conducted by the author and by others. Refreshingly different. For a book of this length and scientific rigor its price is very reasonable, and it will prove to be a very useful reference book for those who carry out research in this area for many years." @source:--TRENDS IN CELL BIOLOGY @qu:"Although this book is devoted to the bacterial cell cycle, it is also a book on principles in biology and how living systems should be approached. Cooper is deeply convinced that, beneath all differences, a fundamental general unity in biology exists. Besides the unity in biochemistry, is also