Background Lesions in Laboratory Animals

1st Edition

A Color Atlas

Authors: Elizabeth McInnes
Hardcover ISBN: 9780702035197
eBook ISBN: 9780702049248
Imprint: Saunders Ltd.
Published Date: 11th October 2011
Page Count: 256


Background Lesions in Laboratory Animals will be an invaluable aid to pathologists needing to recognize background and incidental lesions while examining slides taken from laboratory animals in acute and chronic toxicity studies, or while examining exotic species in a diagnostic laboratory. It gives clear descriptions and illustrations of the majority of background lesions likely to be encountered. Many of the lesions covered are unusual and can be mistaken for treatment-related findings in preclinical toxicity studies.

The Atlas has been prepared with contributions from experienced toxicological pathologists who are specialists in each of the laboratory animal species covered and who have published extensively in these areas.

Key Features

  • over 600 high-definition, top-quality color photographs of background lesions found in rats, mice, dogs, minipigs, non-human primates, hamsters, guinea pigs and rabbits

  • a separate chapter on lesions in the reproductive systems of all laboratory animals written by Dr Dianne Creasy, a world expert on testicular lesions in laboratory animals

  • a chapter on common artifacts that may be observed in histological glass slides

  • extensive references to each lesion described

  • aging lesions encountered in all laboratory animal species, particularly in rats in mice which are used for carcinogenicity studies

Table of Contents

Chapter 1 - Non human primates. Cynomolgus monkey (Maccaca fascicularis) and marmoset (Callithrix jacchus)

Chapter 2 – Wistar and CD rat

Chapter 3 – Beagle Dog

Chapter 4 – Mouse

Chapter 5 – Syrian Hamster

Chapter 6 – Minipig

Chapter 7 – Rabbit

Chapter 8 – Artifacts in processed tissues

Chapter 9 – Reproduction of the Rat, Dog, Primate and Pig


No. of pages:
© Saunders Ltd. 2011
Saunders Ltd.
eBook ISBN:
Hardcover ISBN:

About the Author

Elizabeth McInnes

Affiliations and Expertise

Senior Pathologist


"This 256- volume, although slim, fills a very large hole in the current literature, one that is often encountered by a wide range of veterinary pathologists, from toxicologoical pathologists who work with laboratory species on a daily basis...It's not that you can't afford to buy this book; it's that you can't afford not to buy this book."

Davis Foundation Newsletter, November 2011

"To those working in toxicological and research pathology, it (is) likely to be used on an almost daily basis. In fact, given the large numbers of animal-based studies being carried out in universities and other research institutions, this atlas will also benefit those scientists who read their own histology...In summary, this is an excellent reference atlas and is likely to a valuable tool for a wide range of pathologists."

Veterinary Record, February 2012

"This book will be an important contribution to the science of laboratory animal and toxicological pathology. It is a concise summary of lesions attributed to species, strains, age, sex etc., i.e designated 'background lesions, seen in the primary animal species used in research laboratories'."

Austalian Veterinary Pathology Society, February 2012

"This concise volume fills a gaping void in the existing toxicologic pathology knowledge base that is regularly encountered by pathologists, toxicologists, regulatory scientists and basic researchers...This reference provides an excellent source for defining the potential relevance of 'normal abnormalities' when compiling pathology data sets...In summary, newcomers to the field will recieve the most benefit, but seasoned veterans will also profit by rediscovering man seldom-seen acquaintances and gaining a wealth of citations for further honing their skills. Background Lesions in Laboratory Animals: A Color Atlas is a timely addition to the toxicologic pathology armamentarium, and it is destined to remain a boon c