B-Endorphin

B-Endorphin

1st Edition - November 28, 1981

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  • Editor: Choh Hao Li
  • eBook ISBN: 9780323153348

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Description

Hormonal Proteins and Peptides: β-Endorphin, Volume X focuses on the chemistry, biology, and clinical investigations of opioid peptides. This book discusses the chemical approach in isolating a chemical entity from its natural source and investigates its biological activity after it has been determined to be a pure substance. Organized into nine chapters, this volume starts with an overview of the structure–activity relationship of β-endorphin (β-EP) by synthetic approach. This text then explores the proteinases involved in the generation of opioid peptides, including β-EP from β-lipotropin (β-LPH). Other chapters review the biosynthesis of β-EP and consider in detail the opiate receptor. This book discusses as well the anatomy of β-EP-containing structures in pituitary and brain. The final chapter presents a discussion on the historical aspects of opiate–peptide discoveries, particularly in the field of narcotic antagonists. This book is a valuable resource for chemists, biologists, endocrinologists, physicians, and neurobiologists.

Table of Contents


  • Contributors

    Preface

    Contents of Previous Volumes

    1 β-Endorphin: Synthetic Analogs and Structure-Activity Relationships

    I. Introduction

    II. Synthesis of ß-Endorphin and Analogs

    III. Structure-Activity Relationship by Synthetic Approach

    IV. Concluding Remarks

    References

    2 Characterization of Proteinases Involved in the Generation of Opioid Peptides from β-Lipotropin

    I. Introduction

    II. Hypophyseal and Brain Opioid Peptides Structurally Homologous to ß-LPH

    III. Hypophyseal and Brain Proteinases Generating Opioid Peptides from ß-LPH

    IV. The Regulatory Role of Adenohypophyseal Tryps in-like Proteinases in the Biosynthesis of ß-EP/ACTH

    V. Subcellular Fractionation of Adenohypophyseal Trypsin-like Proteinases

    VI. Purification and Biochemical Characterization of Secretory Granule Bound Trypsin-like Proteinases of the Adenohypophysis

    VII. Characterization and Isolation of a Brain Proteinase That Generates γ-Endorphin from ß-Endorphin: Identification with Lysosomal Cathepsin D

    VIII. The Conversion of β-Endorphin into α- and γ-Endorphins, Met-Enkephalin, and Other Fragments: Metabolism and/or Biotransformation?

    IX. Concluding Remarks

    References

    3 Biosynthesis of β-Endorphin from Proopiomelanocortin

    I. Introduction

    II. Biosynthesis and Segregation of the Proproteins

    III. Maturation of the Secretory Proteins

    IV. Biosynthesis of ß-Endorphin, MSHs, and ACTH from Proopiomelanocortin

    V. Structure of Proopiomelanocortin

    VI. Conclusions

    References

    4 The Opiate Receptor

    I. Introduction

    II. Relationship of Opiate Binding to Pharmacological Effects

    III. Characteristics of Opiate Binding

    IV. Relationship of Opiate Binding to Other Cellular Processes

    V. Isolation of Opiate Binding Material

    VI. Biological Roles of the Opiate Receptor

    VII. Summary and Future Directions

    References

    5 Anatomy of β-Endorphin-Containing Structures in Pituitary and Brain

    I. Introduction

    II. Immunocytochemistry: General Techniques, Strengths, and Weaknesses

    III. ß-Endorphin, ß-Lipotropin, ACTH, and Related Peptides

    IV. Conclusion

    References

    6 Neurobiology of β-Endorphin and Related Peptides

    I. Introduction

    II. Electrophysiology and Neurotransmitter Interactions

    III. ß-Endorphin: Electroencephalographic Effects and Seizures

    IV. Endorphin-Neuroendocrine Interactions

    V Endorphin Involvement in Analgesia

    VI. Thermoregulation and Endorphins

    VII. Respiration and Endorphin Involvement

    VIII. Endorphins in Cardiovascular Function

    IX. Perspectives and Conclusions

    References

    7 Studies of ß-Endorphin in Patients with Mental Illness

    I. Endorphins in Schizophrenia

    II. Endorphins in Affective Disorders

    III. Clinical Studies

    References

    8 Studies of ß-Endorphin in Patients with Pain and Drug Addiction

    I. Introduction

    II. Pharmacokinetics

    III. Analgesia

    IV. Opiate Dependence

    V. Physiologic Effects

    VI. Side Effects

    VII. Summary and Conclusions

    References

    9 The Props for Opiate-Peptide Discoveries and Research

    I. Chauncey Depew Leake (1896-1978)

    II. Development of Narcotic Antagonists

    III. Pharmacology and Application of Antagonists

    References

    Index

Product details

  • No. of pages: 378
  • Language: English
  • Copyright: © Academic Press 1981
  • Published: November 28, 1981
  • Imprint: Academic Press
  • eBook ISBN: 9780323153348

About the Editor

Choh Hao Li

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