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Autophagy in Immune Response: Impact on Cancer Immunotherapy - 1st Edition - ISBN: 9780128196090, 9780128227572

Autophagy in Immune Response: Impact on Cancer Immunotherapy, Volume 1

1st Edition

Editor: Salem Chouaib
Hardcover ISBN: 9780128196090
eBook ISBN: 9780128227572
Imprint: Academic Press
Published Date: 11th May 2020
Page Count: 242
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Table of Contents

  1. Signaling pathways that control autophagy
    2. Autophagosome biogenesis
    3. Autophagy in T and B cell homeostasis: Recycling for sustainable growth
    4. Autophagy is involved in quality/quantity control of organelles and their homeostasis
    5. Role of autophagy in immune regulation
    6. Autophagy in natural and therapy-driven anticancer immunosurveillance
    7. Autophagy and resistance to cell-mediated cytotoxicity
    8. Autophagy and metabolism
    9. Autophagy in connecting immunity and metabolism
    10. Autophagy in tumor cell migration and invasion, tumor stem cell maintenance and therapy resistance
    11. Autophagy during Early Virus-Host Cell Interactions
    12. Diverse roles for autophagy in impeding and promoting tumorigenesis
    13. The autophagic network and cancer
    14. Targeting Autophagy in the Tumor Microenvironment
    15. Autophagy and microbiota
    16. Regulation of autophagy and mitochondrial dynamics
    17. Autophagy proteins in cell defenses and role in bacteria-macrophage interaction
    18. Autophagy, a key player in leukemogenesis and a therapeutic target in hematopoietic malignancies
    19. Autophagy in Cancer and Cancer Therapy
    20. Autophagy in the Tumor or in the Host: Which Plays a Greater Supportive Role?
    21. Autophagy and cancer therapy
    22. Therapeutic potential of autophagy modulation in the clinic
    23. Rationale and current approaches for developing autophagy inducers in medicine
    24. Autophagy and metabolism


Autophagy in Immune Response: Impact on Cancer Immunotherapy focuses on the status and future directions of autophagy with respect to different aspects of its interaction with the immune system and immunotherapy. The book takes scientific research in autophagy a step further by presenting reputable information on the topic and offering integrated content with advancements in autophagy, from cell biology and biochemical research, to clinical treatments. This book is a valuable source for cancer researchers, oncologists, graduate students and several members of biomedical field who are interested in learning more on the relationship between autophagy and immunotherapies.

Key Features

  • Presents updated knowledge on autophagy at the basic level and its potential use in cancer treatment
  • Offers the first book to cover autophagy at the interface of cell biology, immunology and tumor biology
  • Provides a wealth of information on the topic in a coherent and comprehensive collection of contributions by world renowned scientists and investigators


Cancer researchers, medical scientists, clinicians, graduate students


No. of pages:
© Academic Press 2020
11th May 2020
Academic Press
Hardcover ISBN:
eBook ISBN:


"series on the Tumor Microenvironment (edited by Alexander Birbrair, published by Springer), which has published several volumes already, but none dedicated to autophagy. In general, this book has an ambitious goal of summarizing the current state of knowledge regarding autophagy's role in anti-tumor immune responses, but unfortunately, there does not seem to be a lot known, which results in a number of the chapters appearing fairly repetitive and redundant. Some other chapters are able to provide interesting reviews on topics related to tumor immunology but with a tenuous connection to autophagy, such as the chapter on lectins, while some others thoroughly discuss interesting mechanisms of autophagy regulation but with only brief references to immune regulation, such as the chapter on Yin-Yang 1. Accordingly, this book could have better achieved its goals by consolidating some of the chapters (such as eight or nine chapters instead of 11) for ease of reading, but nevertheless represents a very useful resource for researchers interested in this emerging field. There are no previous editions to this work, but as more is discovered, a newer edition would be extremely beneficial." --Doody

Ratings and Reviews

About the Editor

Salem Chouaib

For more than 20 years Dr. Salem Chouaib has focused his research on killer cells and cell death; he first was interested in the differentiation of cytotoxic T lymphocytes, then in the molecular basis of tumor resistance to the cytotoxic action of TNF. During the past ten years, Dr. Chouaib’s research was devoted to the influence of tumor microenvironment on stroma reactivity and tumor heterogeneity. His team was the first to establish the link between hypoxic stress and the acquisition of tumor resistance to cell-mediated cytotoxicity; they found in fact that autophagy was a potential pathway linking hypoxia to the acquisition of resistant phenotype including stemness and epithelial to mesenchymal transition. Dr. Chouaib has a wide knowledge of the killing mechanisms and the tumor resistance as well.

Affiliations and Expertise

Research Director, Gustave Roussy Cancer Center, Villejuif, France