Autophagy in Health and Disease

Autophagy in Health and Disease

1st Edition - June 18, 2020

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  • Editors: Lorenzo Galluzzi, Aitziber Buque
  • Hardcover ISBN: 9780128220214
  • eBook ISBN: 9780128220221

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Autophagy in Health and Disease, Volume 175, presents the latest insights from renowned experts in the field who discuss the key role of autophagic responses in the preservation of cellular and organismal homeostasis and how defects in the molecular apparatus for autophagy drive or accompany disease. Specific chapters in this new release include Crosstalk between autophagy and cell death signaling: mechanisms and therapeutic relevance, C. elegans to model autophagy-related human disorders, Autophagy in Kidney Disease: advances and therapeutic potential, Autophagy in Chronic Lung Disease, Autophagy in motoneuronal disorders, Strategies employed by viruses to manipulate autophagy, and much more.

Key Features

  • Provides an outstanding panel of recognized experts in the field who discuss the latest in autophagy
  • Includes critical discussions of autophagy in the context of each major human disorder
  • Models autophagy-related human pathologies in lower eukaryotes


Equally addressed to expert researchers who may want to extend their technical portfolio, and to beginners in this exciting and rapidly growing field of investigation

Table of Contents

  • Preface - Autophagy: An old mechanism with new challenges ahead
    Aitziber Buqué and Lorenzo Galluzzi
    1. Nucleophagy mediators and mechanisms
    Margarita-Elena Papandreou and Nektarios Tavernarakis
    2. Scaffold proteins in bulk and selective autophagy
    Christopher Eickhorst, Mariya Licheva and Claudine Kraft
    3. A global view of the miRNA-mitophagy connexion
    Flavie Strappazzon
    4. Crosstalk between autophagy and apoptosis: Mechanisms and therapeutic implications
    Andrew Thorburn
    5. Autophagy in immunity
    Christian Münz
    6. Autophagy in cardiovascular health and disease 
    Mahmoud Abdellatif, Senka Ljubojevic-Holzer, Frank Madeo and Simon Sedej
    7. Autophagy in kidney disease: Advances and therapeutic potential
    Divya Bhatia and Mary E. Choi
    8. Autophagy in chronic lung disease
    Alexandra C. Racanelli, Augustine M.K. Choi and Mary E. Choi
    9. Autophagy contribution to motor neuron disease pathology
    Natalia Rodríguez-Muela
    10. Strategies employed by viruses to manipulate autophagy
    Nilima Dinesh Kumar, Jolanda M. Smit and Fulvio Reggiori
    11. Crinophagy mechanisms and its potential role in human health and disease
    Tamás Csizmadia and Gábor Juhász
    12. Autophagy role in environmental pollutants exposure
    Gemma G. Martínez-García and Guillermo Mariño
    13. Genetic defects of autophagy linked to disease
    Milana Fraiberg and Zvulun Elazar
    14. C. elegans to model autophagy-related human disorders
    Shi Q. Wong, Anita V. Kumar, Joslyn Mills and Louis R. Lapierre
    15. Drosophila as a model to understand autophagy deregulation in human disorders
    Donna Denton, Louise O'Keefe and Sharad Kumar

Product details

  • No. of pages: 444
  • Language: English
  • Copyright: © Academic Press 2020
  • Published: June 18, 2020
  • Imprint: Academic Press
  • Hardcover ISBN: 9780128220214
  • eBook ISBN: 9780128220221

About the Serial Volume Editors

Lorenzo Galluzzi

Lorenzo Galluzzi
Lorenzo Galluzzi is Assistant Professor of Cell Biology in Radiation Oncology at the Department of Radiation Oncology of the Weill Cornell Medical College, Honorary Assistant Professor Adjunct with the Department of Dermatology of the Yale School of Medicine, Honorary Associate Professor with the Faculty of Medicine of the University of Paris, and Faculty Member with the Graduate School of Biomedical Sciences and Biotechnology of the University of Ferrara, the Graduate School of Pharmacological Sciences of the University of Padova, and the Graduate School of Network Oncology and Precision Medicine of the University of Rome “La Sapienza”. Moreover, he is Associate Director of the European Academy for Tumor Immunology and Founding Member of the European Research Institute for Integrated Cellular Pathology. Galluzzi is best known for major experimental and conceptual contributions to the fields of cell death, autophagy, tumor metabolism and tumor immunology. He has published over 450 articles in international peer-reviewed journals and is the Editor-in-Chief of four journals: OncoImmunology (which he co-founded in 2011), International Review of Cell and Molecular Biology, Methods in Cell biology, and Molecular and Cellular Oncology (which he co-founded in 2013). Additionally, he serves as Founding Editor for Microbial Cell and Cell Stress, and Associate Editor for Cell Death and Disease, Pharmacological Research and iScience.

Affiliations and Expertise

Assistant Professor of Cell Biology in Radiation Oncology, Department of Radiation Oncology, Weill Cornell Medical College, NY, USA

Aitziber Buque

Aitziber Buqué (born 1980) is currently Post-Doctoral Fellow in the laboratory of Dr. Lorenzo Galluzzi with the Department of Radiation Oncology of the Weill Cornell Medical College (New York, NY, USA). Prior to joining the Galluzzi lab (2018), Aitziber Buqué was a Post-Doctoral Fellow in the Research Team “Apoptosis, Cancer and Immunity” at the Cordeliers Research Center (Paris, France; 2014-2018), under the direction of Dr. Guido Kroemer, after receiving her PhD from the University of the Basque Country (Leioa, Spain; 2013). Aitziber Buqué is interested in the molecular, cellular and immunological mechanisms whereby breast cancer evades immunosurveillance and resists to immunotherapy, and she is the author of more than 30 scientific articles in international peer-reviewed journals.

Affiliations and Expertise

Post-Doctoral Fellow, Department of Radiation Oncology of the Weill Cornell Medical College, New York, NY, USA

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