Autophagy Dysfunction in Alzheimer's Disease and Dementia

Autophagy Dysfunction in Alzheimer's Disease and Dementia

1st Edition - August 1, 2022

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  • Editors: Tadanori Hamano, Tatsuro Mutoh
  • Paperback ISBN: 9780323899062

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Autophagy Dysfunction in Alzheimer’s Disease and Dementia provides an overview for researchers and clinicians on the mechanisms involved in protein degradation in Alzheimer’s. The book discusses the implication of autophagy dysfunction in these diseases and how it causes degenerated proteins, including aggregated tau and aggregated amyloid protein. Other sections explores the possibilities of potential drug development through autophagy modulation, making this a great resource on the study of how autophagy dysfunction has been linked to the accumulation of misfolded proteins that cause death of neurons in Alzheimer’s and other neurodegenerative diseases.

Key Features

  • Discusses the implication of autophagy dysfunction in neurodegenerative diseases
  • Highlights the mechanisms involved in protein degradation
  • Explores the possibilities of drug development through autophagy modulation


Neuroscientists, neurologists, psychiatrists and geriatricians. Advanced graduate students

Table of Contents

  • Section I. Degradation Mechanisms of Cells
    1. Degradation Mechanisms of Cells

    Section II. Lysosomes
    2. Lysosomes- neuronal degeneration in lysosomal storage disorders

    Section III. The Autophagic Pathways
    3. The autophagy pathway and its key regulators

    Section IV. Amyloid Beta Protein and Autophagy
    4. Basics of Amyloid beta protein in Alzheimer’s disease
    5. Molecular linkages among Aβ, tau, impaired mitophagy, and mitochondrial dysfunction in Alzheimer’s disease
    6. Endocytosis in Β-amyloid biology and Alzheimer’s Disease

    Section V. Autophagy and Tau Protein
    7. Tau protein degrade by autophagy
    8. BAG3 promotes tau clearance by regulating autophagy and other vacuolar dependent degradative processes 
    9. Tau propagation and Autophagy

    Section VI. Autophagy and Pathology in Alzheimer’s Disease
    10. Autophagy and pathology -Granulovacuolar degeneration in neurodegeneration
    11. Autophagy dysfunction in skeletal myopathies: Inclusion body myositis and Danon disease
    Section VII. Autophagy and Other Disorders Causing Dementia
    12. Autophagy in Lewy body diseases and multiple system atrophy    
    13. Autophagy and Huntington’s disease

    Section VIII. Drug Discovery in Alzheimer’s Disease by Modulating Autophagy
    14. Drug discovery in Alzheimer’s disease by regulating autophagy
    15. Drug discovery in Alzheimer's disease using metal chelators: Warning toward their uses
    16. Development of autophagy enhancers for Parkinson's disease therapy


Product details

  • No. of pages: 300
  • Language: English
  • Copyright: © Academic Press 2022
  • Published: August 1, 2022
  • Imprint: Academic Press
  • Paperback ISBN: 9780323899062

About the Editors

Tadanori Hamano

Dr. Tadanori Hamano is a Clinical Professor in the Department of Neurology at University of Fukui Hospital. He’s also an Associate Professor, on the Second Department of Internal Medicine, Faculty of Medical Sciences at University of Fukui. His clinical service focuses on patients with diseases involving the central and peripheral nervous system. His research is focused on autophagic activation in the treatment of Alzheimer’s disease.

Affiliations and Expertise

Clinical Professor, Department of Neurology, University of Fukui Hospital, Fukui, Fukui, Japan; Associate Professor, Second Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan

Tatsuro Mutoh

Tatsuro Mutoh, MD, PhD got his MD and PhD degree from Nagoya University School of Medicine, Japan in 1980 and 1986, respectively. He was appointed as assistant Prof. at Fukui Medical School in 1986. Then, he moved to National Institutes of Health (NIH), NICHD, USA as a visiting fellow from 1987-1990, where he purified novel nerve growth factor-responsive protein kinases and was engaged in the analyses of signal transduction of neurotrophic factors in neuronal cells. He was promoted to full professor and Chairman at Department of Neurology, Fujita Health University School of Medicine, Japan in 2006 and was ordered to serve concurrently to Fujita Health University Chubu International Airport Medical Clinic as a Director and Prof. in 2020. His expertise is neuroglycobiology of neurodegenerative disorders, protein-lipid interaction, and neuroimmunology. He has been acting as board member of Front Cell Neurosci, Front In Biosci and so on.

Affiliations and Expertise

Professor, Department of Neurology and Neuroscience, Fujita Health University Hospital, Toyoake-City, Aichi-Pref., Japan

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