Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging - 1st Edition - ISBN: 9780128054215, 9780128094280

Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging

1st Edition

Volume 10

Editors: M. Hayat
eBook ISBN: 9780128094280
Hardcover ISBN: 9780128054215
Imprint: Academic Press
Published Date: 14th June 2016
Page Count: 370
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Description

Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging, Volume 10 offer a valuable guide to both cellular processes, while encouraging researchers to explore their potentially important connections. Autophagy serves to maintain healthy cells, tissues, and organs, but also promotes cancer survival and growth of established tumors. Impaired or deregulated autophagy can also contribute to disease pathogenesis.

This is the tenth volume of the multivolume series that discusses, in detail, almost all aspects of the autophagy machinery in the context of health, cancer, and other pathologies. Autophagy maintains homeostasis during starvation or stress conditions by balancing the synthesis of cellular components and their deregulation by autophagy. Volume 10 of the Autophagy series discusses the role of a novel binuclear palladacycle complex that inhibits melanoma growth through apoptosis and autophagy.

Key Features

  • Presents the most advanced information regarding the role of the autophagic system in life and death
  • Contains a direct focus on the role of a novel binuclear palladacycle complex that inhibits melanoma growth
  • Introduces new, more effective therapeutic strategies in the development of targeted drugs and programmed cell death, providing information that will aid in preventing detrimental inflammation
  • States recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities
  • Edited work with chapters authored by leaders in the field from around the globe—the broadest, most expert coverage available

Readership

Academic/clinical professors, post-doctoral fellows, graduate and medical students in immunology, microbiology, pathology, infectious diseases and cancer research

Table of Contents

I. Molecular Mechanisms
Chapter 1. Overview of Autophagy
Chapter 2. Molecular Mechanisms Underlying the Degradation of Peroxisomes
Chapter 3. Role of Poly (ADP-Ribose) in Catalyzing Starvation-Induced Autophagy
Chapter 4. Cross-Talk Between Autophagy and Death Receptor Signaling Pathways
Chapter 5. Role of Autophagy in Mammalian Embryogenesis: Response to Developmental Programs
Chapter 6. Autophagy in Adipose Tissue
Chapter 7. Prevention of Adverse Metabolic Consequences of Adipocyte Dysfunction Using MR Antagonists
Chapter 8. A Rapid Method for Detecting Autophagy Activity in Live Cells Using Cellometer Image Cytometry

II. Role in Disease
Chapter 9. CDC37: Implications in Regulation of Kinases and Proteins Linked to Neurodegenerative and Other Diseases
Chapter 10. Autophagy in the Degeneration of Optic Nerve and Spinal Cord Axons
Chapter 11. Membrane Type-1 Matrix Metalloproteinase-Regulated Autophagy: A Role in Brain Cancer Chemoresistance
Chapter 12. Induction of Autophagy and Apoptosis in Melanoma Treated with Palladacycle Complexes
Chapter 13. Autophagy in Atherosclerosis
Abbreviations and Glossary
Index

Details

No. of pages:
370
Language:
English
Copyright:
© Academic Press 2016
Published:
Imprint:
Academic Press
eBook ISBN:
9780128094280
Hardcover ISBN:
9780128054215

About the Editor

M. Hayat

M. Hayat

Dr. Hayat has published extensively in the fields of microscopy, cytology, immunohistochemistry, immunocytochemistry, and antigen retrieval methods. He is Distinguished Professor, Department of Biological Sciences, Kean University, Union, New Jersey, USA.

Affiliations and Expertise

Distinguished Professor, Department of Biological Sciences, Kean University, Union, NJ, USA