Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging - 1st Edition - ISBN: 9780128010327, 9780128010532

Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging

1st Edition

Volume 6- Regulation of Autophagy and Selective Autophagy

Editors: M. Hayat
eBook ISBN: 9780128010532
Hardcover ISBN: 9780128010327
Imprint: Academic Press
Published Date: 5th January 2015
Page Count: 338
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Volume 6 provides coverage of the mechanisms of regulation of autophagy; intracellular pathogen use of the autophagy mechanism; the role of autophagy in host immunity; and selective autophagy. Attention is given to a number of mechanistic advances in the understanding of regulation, particularly the importance of nutrient availability; microRNAs; and cross-talk with other protein degradation pathways. Intracellular pathogen repurposing of autophagy for pathogenic benefit is also provided, with coverage of Herpesvirus protein modulation of autophagy; the varicella-zoster virus and the maintenance of homeostasis; and the relationship between autophagy and the hepatitis b virus.

The significance of autophagy in host defense is elucidated, providing a specific focus on facilitation of antigen presentation; participation in thymic development; and the sharing of regulatory nodes with innate immunity. Selective autophagy for the degradation of mitochondria and endocytosed gap junctions are also explored.

This book is an asset to newcomers as a concise overview of the regulation of autophagy, its role in host defense and immunity, and selective autophagy, while serving as an excellent reference for more experienced scientists and clinicians looking to update their knowledge. 


Volumes in the Series

Volume 1: Molecular Mechanisms. Elucidates autophagy’s association with numerous biological processes, including cellular development and differentiation, cancer, immunity, infectious diseases, inflammation, maintenance of homeostasis, response to cellular stress, and degenerative diseases such as Alzheimer’s, Parkinson's, Huntington's, amyotrophic lateral sclerosis, and prion diseases.
Volume 2: Role in General Diseases. Describes the various aspects of the complex process of autophagy in a myriad of devastating human diseases, expanding from a discussion of essential autophagic functions into the role of autophagy in proteins, pathogens, immunity, and general diseases. 
Volume 3: Role in Specific Diseases. Explores the role of autophagy in specific diseases and developments, including: Crohn’s Disease, Gaucher Disease, Huntington’s Disease, HCV infection, osteoarthritis, and liver injury, with a full section devoted to in-depth exploration of autophagy in tumor development and cancer, as well as the relationship between autophagy and apoptosis.
Volume 4: Mitophagy. Presents detailed information on the role of mitophagy, the selective autophagy of mitochondria, in health and disease, by delivering an in-depth treatment of the molecular mechanisms involved in mitophagy initiation and execution, as well as the role of mitophagy in Parkinson Disease, cardiac aging, and skeletal muscle atrophy.
Volume 5: Role in Human Diseases. Comprehensively describes the role of autophagy in human diseases, delivering coverage of the antitumor and protumor roles of autophagy; the therapeutic inhibition of autophagy in cancer; and the duality of autophagy’s effects in various cardiovascular, metabolic, and neurodegenerative disorders.
Volume 6: Regulation of Autophagy and Selective Autophagy. Provides coverage of the mechanisms of regulation of autophagy; intracellular pathogen use of the autophagy mechanism; the role of autophagy in host immunity; and selective autophagy.
Volume 7: Role of Autophagy in Therapeutic Applications. Provides coverage of the latest developments in autophagosome biogenesis and regulation; the role of autophagy in protein quality control; the role of autophagy in apoptosis; autophagy in the cardiovascular system; and the relationships between autophagy and lifestyle. 
Volume 8: Autophagy and Human Diseases. Reviews recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities, and introduces new, more effective therapeutic strategies, in the development of targeted drugs and programmed cell death, providing information that will aid on preventing detrimental inflammation.
Volume 9: Necrosis and Inflammation in Human Diseases. Emphasizes the role of Autophagy in necrosis and inflammation, explaining in detail the molecular mechanism(s) underlying the formation of autophagosomes, including the progression of Omegasomes to autophagosomes.

Key Features

  • Bings together a wide swathe of experts (oncologists, neurosurgeons, physicians, research scientists, and pathologists) in the field of autophagy to discuss recent developments in this rapidly-advancing field
  • Discuses role of autophagy in immunity, with coverage of toll-like receptors as activators for autophagy; role in antigen processing; and control of production and secretion of il-1B
  • Covers role of autophagy receptors in mitophagy; role of parkin and pink1 in mitochondrial quality control; and the degradation of endocytosed gap junctions
  • Organized for readers into easy-to-access sections: autophagy and molecular mechanisms; autophagy and intracellular pathogens; autophagy and immunity; and general applications


Academic/clinical professors, post-doctoral fellows, graduate and medical students in immunology, pathology, infectious diseases, cancer research, oncology, pathology, biology, bioinformatics, endocrinology, gastroenterology, reproductive oncology and public health, and industries in drug development

Table of Contents

  • Dedication
  • Mitophagy and Biogenesis
  • Dedication
  • Autophagy and Cancer
  • Foreword
  • Preface
  • Abbreviations and Glossary
  • Autophagy: Volume 1 – Contributions
  • Autophagy: Volume 2 – Contributions
  • Autophagy: Volume 3 – Contributions
  • Autophagy: Volume 4 – Contributions
  • Autophagy: Volume 5 – Contributions
  • Chapter 1. Introduction to Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging, Volume 6
    • Introduction
    • Specific Functions of Autophagy (A Summary)
    • Autophagy in Normal Mammalian Cells
    • Endoplasmic Reticulum Stress and Autophagy
    • Major Types of Autophagies
    • Autophagosome Formation
    • Autophagic Lysosome Reformation
    • Autophagic Proteins
    • Monitoring Autophagy
    • Reactive Oxygen Species (ROS)
    • Mammalian Target of Rapamycin (mTOR)
    • Role of Autophagy in Tumorigenesis and Cancer
    • Role of Autophagy in Immunity
    • Autophagy and Senescence
    • Role of Autophagy in Viral Defense and Replication
    • Role of Autophagy in Intracellular Bacterial Infection
    • Role of Autophagy in Heart Disease
    • Role of Autophagy in Neurodegenerative Diseases
    • Cross-Talk between Autophagy and Apoptosis
    • Autophagy and Ubiquitination
    • Aggresome: Ubiquitin Proteasome and Autophagy Systems
    • Autophagy and Necroptosis
    • Mitochondrial Fusion and Fission
    • Selective Autophagies
    • References
  • Part I: Autophagy and Molecular Mechanisms
    • Chapter 2. Regulation of Autophagy by Amino Acids
      • Introduction
      • Overview of the Insulin-Amino Acid-MTOR Signaling Pathway
      • Amino Acids, MTOR Signaling and the Regulation of Autophagy
      • Amino Acids, Beclin-1 and the Regulation of Autophagy
      • Conclusion
      • References
    • Chapter 3. Regulation of Autophagy by Amino Acid Starvation Involving Ca2+
      • Introduction
      • Regulation of Autophagy by Amino Acids
      • Ca2+-dependent Activation of Autophagy by Amino Acid Starvation
      • Ca2+/CaMKK-β-dependent Autophagy and Energy
      • Conclusion
      • Acknowledgments
      • References
    • Chapter 4. Regulation of Autophagy by microRNAs
      • Introduction
      • Molecular Mechanisms of Autophagy
      • Major Signaling Pathways Regulating Autophagy
      • Small Regulators: microRNAs, their Biogenesis and Biological Functions
      • micrornas: Novel Regulators of Autophagy
      • microRNA Regulation of Autophagy-Related Signaling Pathways
      • Conclusion
      • Acknowledgments
      • References
    • Chapter 5. Mechanisms of Cross-Talk between Intracellular Protein Degradation Pathways
      • Introduction
      • The Ubiquitin-Proteasome System: Selective Degradation of Cytoplasmic Proteins
      • The Three Branches of Autophagy: Diverse Regulation of Lysosome-Dependent Degradation
      • Regulation of Intracellular Proteolysis by Cross-Talk Between Degradation Pathways
      • Functional Implications of Cross-Talk: Autophagy Can Compensate for Ups Impairment but Not Vice Versa
      • Insights into the Physiological Consequences of Perturbed Proteolysis: Focus on Aging
      • Conclusion
      • Acknowledgments
      • References
    • Chapter 6. Cross-Talk between Autophagy and Apoptosis in Adipose Tissue: Role of Ghrelin
      • Introduction
      • Apoptosis and Autophagy in Adipose Tissue
      • Role of Ghrelin in the Regulation of Apoptosis and Autophagy in Adipose Tissue
      • Discussion
      • Acknowledgments
      • References
  • Part II: Autophagy and Intracellular Pathogens
    • Chapter 7. Intracellular Pathogen Invasion of the Host Cells: Role of α-Hemolysin- Induced Autophagy
      • Introduction
      • Staphylococcus Aureus
      • The S. Aureus α-hemolysin, a Key Secreted Virulence Factor
      • Discussion
      • References
    • Chapter 8. Modulation of Autophagy by Herpesvirus Proteins
      • Introduction
      • Inhibition of Autophagy by Herpesvirus Proteins
      • Autophagy Activation by Herpesviruses
      • Conclusion
      • Acknowledgments
      • References
    • Chapter 9. Autophagy Induced by Varicella-Zoster Virus and the Maintenance of Cellular Homeostasis
      • Introduction
      • Varicella-Zoster Virus
      • The Disease Varicella
      • Characteristic Exanthems of Varicella and Herpes Zoster
      • Autophagy and its Visualization by Confocal Microscopy
      • Autophagosomes in the Exanthems of Varicella and Herpes Zoster
      • Evidence for ER Stress and Unfolded Protein Response
      • Acknowledgments
      • References
    • Chapter 10. Autophagy and Hepatitis B Virus
      • Introduction
      • The HBV Life Cycle
      • Mechanism of HBV-Induced Autophagy
      • Autophagy on HBV Replication
      • Autophagy and HBV-Induced Hepatocarcinogenesis
      • Conclusion
      • References
  • Part III: Autophagy and Immunity
    • Chapter 11. Toll-Like Receptors Serve as Activators for Autophagy in Macrophages Helping to Facilitate Innate Immunity
      • Introduction
      • Toll-Like Receptors
      • Autophagy
      • TLR-Induced Autophagy
      • Discussion
      • Acknowledgments
      • References
    • Chapter 12. Autophagy in Antigen Processing for MHC Presentation to T Cells
      • Introduction
      • Cytosolic Antigen Presentation on MHC Class II Molecules
      • Autophagy Regulation of Phagocytosis
      • Antigen Packaging for Cross-Presentation Via Macroautophagy
      • Regulation of MHC Class I Antigen Processing by Macroautophagy
      • Autophagy and Autoimmunity
      • Discussion
      • Acknowledgments
      • References
    • Chapter 13. Autophagy Controls the Production and Secretion of IL-1β: Underlying Mechanisms
      • Introduction
      • Interleukin-1β: Biological Functions and Regulation
      • Role of Autophagy in Interleukin-1β Secretion
      • Autophagy and Innate Th17 Immune Responses
      • Autophagy and Inflammatory Diseases
      • Conclusion
      • References
    • Chapter 14. Role of Autophagy in P2X7 Receptor-Mediated Maturation and Unconventional Secretion of IL-1β in Microglia
      • Introduction
      • Role of Lysosomes in the Maturation of IL-1β
      • Autophagy Might Regulate the Maturation and Secretion of IL-1β
      • P2X7R-Mediated Maturation and Unconventional Secretion of IL-1β
      • Acknowledgments
      • References
    • Chapter 15. Autophagy Restricts Interleukin-1β Signaling via Regulation of P62 Stability
      • Introduction
      • Discussion
      • Acknowledgments
      • References
    • Chapter 16. Roles of Autophagy in the Thymic Epithelium
      • Introduction
      • Evidence for Autophagy in the Thymic Epithelium
      • Evaluation of Epithelial Autophagy in T Cell Selection
      • Conclusion
      • References
  • Part IV: Autophagy: General Applications
    • Chapter 17. The Role of Autophagy Receptors in Mitophagy
      • Introduction
      • Autophagy Receptors
      • Mitophagy
      • Discussion
      • Acknowledgments
      • References
    • Chapter 18. The Role of Parkin and PINK1 in Mitochondrial Quality Control
      • Introduction
      • Parkinson’s Disease and Mitochondrial Dysfunction
      • Parkin and PINK1 Mutant Flies
      • Stabilization of PINK1 on Mitochondria
      • PINK1 Activity on the Mitochondria
      • Parkin: A PD-Associated E3-Ubiquitin Ligase
      • PINK1-Mediated Recruitment of Parkin onto Mitochondria
      • Parkin-Mediated Ubiquitination of Mitochondrial Proteins
      • Parkin/PINK1-Mediated Mitophagy
      • Mitophagy and Neurons
      • Discussion
      • References
    • Chapter 19. Autophagy Degrades Endocytosed Gap Junctions
      • Introduction
      • Results
      • Discussion
      • Conclusion
      • Acknowledgments
      • References
  • Index


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© Academic Press 2015
Academic Press
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About the Editor

M. Hayat

M. Hayat

Dr. Hayat has published extensively in the fields of microscopy, cytology, immunohistochemistry, immunocytochemistry, and antigen retrieval methods. He is Distinguished Professor, Department of Biological Sciences, Kean University, Union, New Jersey, USA.

Affiliations and Expertise

Distinguished Professor, Department of Biological Sciences, Kean University, Union, NJ, USA

Ratings and Reviews