Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging

Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging

Volume 1 - Molecular Mechanisms

1st Edition - July 29, 2013

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  • Editor: M. Hayat
  • Hardcover ISBN: 9780124055308
  • eBook ISBN: 9780124055353

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Description

Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and forward thinking, these books offer a valuable guide to both cellular processes while inciting researchers to explore their potentially important connections. Considering that autophagy is associated with numerous biological processes, including cellular development and differentiation, cancer (both antitumor and protumor functions), immunity, infectious diseases, inflammation, maintenance of homeostasis, response to cellular stress, and degenerative diseases such as Alzheimer’s, Parkinson's, Huntington's, amyotrophic lateral sclerosis, and prion diseases, there is a great need to understanding its role. Cell homeostasis is achieved by balancing biosynthesis and cellular turnover. In spite of the increasing importance of autophagy in various pathophysiological situations (conditions) mentioned above, this process remains underestimated and overlooked. As a consequence, its role in the initiation, stability, maintenance, and progression of these and other diseases (e.g., autoimmune disease) remains poorly understood. Volumes in the Series Volume 1: Molecular Mechanisms. Elucidates autophagy’s association with numerous biological processes, including cellular development and differentiation, cancer, immunity, infectious diseases, inflammation, maintenance of homeostasis, response to cellular stress, and degenerative diseases such as Alzheimer’s, Parkinson's, Huntington's, amyotrophic lateral sclerosis, and prion diseases. Volume 2: Role in General Diseases. Describes the various aspects of the complex process of autophagy in a myriad of devastating human diseases, expanding from a discussion of essential autophagic functions into the role of autophagy in proteins, pathogens, immunity, and general diseases.  Volume 3: Role in Specific Diseases. Explores the role of autophagy in specific diseases and developments, including: Crohn’s Disease, Gaucher Disease, Huntington’s Disease, HCV infection, osteoarthritis, and liver injury, with a full section devoted to in-depth exploration of autophagy in tumor development and cancer, as well as the relationship between autophagy and apoptosis.Volume 4: Mitophagy. Presents detailed information on the role of mitophagy, the selective autophagy of mitochondria, in health and disease, by delivering an in-depth treatment of the molecular mechanisms involved in mitophagy initiation and execution, as well as the role of mitophagy in Parkinson Disease, cardiac aging, and skeletal muscle atrophy. Volume 5: Role in Human Diseases. Comprehensively describes the role of autophagy in human diseases, delivering coverage of the antitumor and protumor roles of autophagy; the therapeutic inhibition of autophagy in cancer; and the duality of autophagy’s effects in various cardiovascular, metabolic, and neurodegenerative disorders.Volume 6: Regulation of Autophagy and Selective Autophagy. Provides coverage of the mechanisms of regulation of autophagy; intracellular pathogen use of the autophagy mechanism; the role of autophagy in host immunity; and selective autophagy. Volume 7: Role of Autophagy in Therapeutic Applications. Provides coverage of the latest developments in autophagosome biogenesis and regulation; the role of autophagy in protein quality control; the role of autophagy in apoptosis; autophagy in the cardiovascular system; and the relationships between autophagy and lifestyle.  Volume 8: Autophagy and Human Diseases. Reviews recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities, and introduces new, more effective therapeutic strategies, in the development of targeted drugs and programmed cell death, providing information that will aid on preventing detrimental inflammation.Volume 9: Necrosis and Inflammation in Human Diseases. Emphasizes the role of Autophagy in necrosis and inflammation, explaining in detail the molecular mechanism(s) underlying the formation of autophagosomes, including the progression of Omegasomes to autophagosomes.

Key Features

  • Presents the most advanced information regarding the role of the autophagic system in life and death and whether autophagy acts fundamentally as a cell survivor or cell death pathway or both
  • Introduces new, more effective therapeutic strategies in the development of targeted drugs and programmed cell death, providing information that will aid on preventing detrimental inflammation
  • States recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities

Readership

Academic/clinical professors, post-doctoral fellows, graduate and medical students in immunology, pathology, infectious diseases, cancer research, oncology, pathology, biology, bioinformatics, endocrinology, gastroenterology, reproductive oncology and public health, industries in drugs development

Table of Contents

  • Dedication

    Dedication

    Preface

    Contributors

    List of Contributions Projected in Volumes 2–4

    Abbreviations and Glossary

    Chapter 1. Introduction to Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection and Aging, Volumes 1–4

    Introduction

    Specific Functions of Autophagy (A Summary)

    Autophagy in Normal Mammalian Cells

    Major Types of Autophagies

    Selective Autophagies

    Autophagosome Formation

    Autophagic Lysosome Reformation

    Autophagic Proteins

    Protein Degradation Systems

    Beclin 1

    Non-Autophagic Function of Autophagy-Related Proteins

    Microtubule-Associated Protein Light Chain 3

    Monitoring Autophagy

    Reactive Oxygen Species (ROS)

    Mammalian Target of Rapamycin (mTOR)

    Role of Autophagy in Tumorigenesis and Cancer

    Role of Autophagy in Immunity

    Role of Autophagy in Viral Defense and Replication

    Role of Autophagy in Intracellular Bacterial Infection

    Role of Autophagy in Heart Disease

    Role of Autophagy in Neurodegenerative Diseases

    Cross-Talk between Autophagy and Apoptosis

    References

    Part I: General Diseases

    Chapter 2. Mechanisms of Regulation of p62 in Autophagy and Implications for Health and Diseases

    Introduction

    LC3 Recognition by p62

    Role of p62 as an Autophagy Receptor

    Discussion

    References

    Chapter 3. Molecular Mechanisms Underlying the Role of Autophagy in Neurodegenerative Diseases

    Autophagy Overview and Types

    Pathway and Mechanism for Autophagy

    Physiological Roles of Autophagy

    Autophagy and Neuronal Physiology

    Autophagy and Neurodegenerative Diseases

    Conclusions and Future Perspective

    Acknowledgments

    References

    Chapter 4. Roles of Multiple Types of Autophagy in Neurodegenerative Diseases

    Degradation of ALS-Linked Mutant SOD1 by Macroautophagy

    Interaction between Parkinson’s Disease-Associated UCH-L1 and Chaperone-Mediated Autophagy

    Degradation of RNA by Rnautophagy: Its Possible Roles in Neurodegenerative Disorders

    References

    Chapter 5. Autophagy and Crohn’s Disease: Towards New Therapeutic Connections

    Introduction: Crohn’s Disease and Faulty Autophagy go Hand in Hand

    Autophagy: A Hot Novel Target or an Old Friend?

    Diagnostic Value of the Autophagic Status

    Concluding Remarks

    References

    Chapter 6. The Role of Autophagy in Atherosclerosis

    Introduction

    Autophagy-Stimulating Factors in Atherosclerosis

    Protective Effects of Autophagy in Atherosclerosis

    Concluding Remarks

    Acknowledgments

    References

    Chapter 7. Treatment of Diabetic Cardiomyopathy through Upregulating Autophagy by Stimulating AMP-Activated Protein Kinase

    Introduction

    Autophagy in the Heart

    Autophagy in Heart Failure

    AMPK in the Heart

    AMPK and Autophagy

    AMPK and Diabetic Cardiomyopathy

    Autophagy in Diabetes and Its Complications

    Activation of AMPK Attenuates Diabetic Cardiomyopathy by Activation of Autophagy

    References

    Chapter 8. Hyperglycemia-Associated Oxidative Stress Induces Autophagy: Involvement of the ROS-ERK/JNK-p53 Pathway

    Introduction

    Oxidative Stress in Hyperglycemia

    Autophagy in Hyperglycemia

    ROS-ERK/JNK-p53 Pathway Activates Autophagy in Hyperglycemia

    Discussion

    References

    Chapter 9. Role of Autophagy in Cellular Defense Against Inflammation

    Introduction

    Innate Immunity, Inflammation and Autophagy

    Diseases Related to Inflammation and Autophagy

    Inflammasomes and Autophagy

    Discussion

    Acknowledgments

    References

    Chapter 10. Mitophagy Plays a Protective Role in Fibroblasts from Patients with Coenzyme Q10 Deficiency

    Introduction

    Coenzyme Q10 Deficiency

    Mitochondrial Dysfunction in Coenzyme Q10 Deficiency

    Mitophagy

    Mitophagy in Primary Coenzyme Q10 Deficiency

    Mitophagy in Secondary Coenzyme Q10 Deficiency

    Conclusions

    Acknowledgments

    References

    Chapter 11. The Presence of Dioxin in Kidney Cells Induces Cell Death with Autophagy

    Introduction

    TCDD and Autophagy in Kidney Cells

    Conclusion

    Acknowledgments

    References

    Part II: Cancer

    Chapter 12. Molecular Mechanisms Underlying the Activation of Autophagy Pathways by Reactive Oxygen Species and their Relevance in Cancer Progression and Therapy

    Introduction

    Overview of Autophagy Core Machinery and Signaling Pathways

    Reactive Oxygen Species: Cellular Sources and Signaling Role

    ROS and Autophagy

    Autophagy, ROS, and Cancer

    Conclusions and Perspectives

    Acknowledgments

    References

    Chapter 13. Induction of Autophagic Cell Death by Anticancer Agents

    Introduction

    Molecular Mechanisms of Autophagy

    Programmed Cell Death and Autophagy

    Induction of Autophagic Cell Death by Anticancer Agents

    Discussion

    Acknowledgments

    References

    Chapter 14. Immunogenicity of Dying Cancer Cells–The Inflammasome Connection: Autophagic Death Arrives on the Scene

    Introduction

    Dying Cells and their Clearance by Immune-Competent Cells

    Dying Cells and the Inflammatory Response

    The Inflammasome and its Activators

    Inflammasome-Activating Damps Released from Necrotic and Apoptotic Cells

    Damps from Autophagic Dying Cells Can Activate the Inflammasomes

    Interferon Regulatory Factors (IRFs) Play a Role in Activation of the Inflammatory Response

    In vivo Evidence of Inflammatory Response to Autophagic Dying Cells

    Concluding Remarks

    Acknowledgments

    References

    Chapter 15. Selenite-Mediated Cellular Stress, Apoptosis, and Autophagy in Colon Cancer Cells

    Introduction

    Selenium

    Effects of Selenite in Colon Cancer Cells

    Discussion

    Acknowledgment

    References

    Chapter 16. Enhancement of Cell Death in High-Grade Glioma Cells: Role of N-(4-Hydroxyphenyl) Retinamide-Induced Autophagy

    Introduction

    Cell Death Induced by Chemotherapeutic Agents

    Retinoids as Chemotherapeutic Agents

    N-(4-Hydroxyphenyl) Retinamide, a Synthetic Retinoid

    N-(4-Hydroxyphenyl) Retinamide: Mechanism of Action

    N-(4-Hydroxyphenyl) Retinamide in Gliomas

    Discussion

    Acknowledgments

    References

    Chapter 17. Cisplatin Exposure of Squamous Cell Carcinoma Cells Leads to Modulation of the Autophagic Pathway

    Introduction

    The Autophagy Pathway Confers Cisplatin Chemoresistance

    TP53 Family Members Modulate Autophagic Signaling Through Transcriptional Regulation

    TP53 Proteins Regulate MicroRNAs that Control Autophagic Signaling

    Discussion

    Acknowledgments

    References

    Part III: Tumors

    Chapter 18. Autophagy, Stem Cells, and Tumor Dormancy

    Introduction

    Autophagy

    Tumor Dormancy

    Autophagy and Stem Cells

    Summary

    References

    Chapter 19. Death-Associated Protein Kinase 1 Suppresses Tumor Growth and Metastasis via Autophagy and Apoptosis

    Introduction

    DAPK1 and Apoptosis

    DAPK1 Regulation

    DAPK1 and Autophagy

    Discussion

    Acknowledgments

    References

    Chapter 20. TRIM13, Novel Tumor Suppressor: Regulator of Autophagy and Cell Death

    Introduction

    TRIM Family Proteins

    TRIM13: Regulator of Autophagy and Tumorigenesis

    Discussion and Conclusions

    Acknowledgments

    References

    Chapter 21. Hypoxia-Induced Autophagy Promotes Tumor Cell Survival

    Introduction

    Hypoxia-Induced Autophagy Promotes Tumor Cell Survival

    Discussion

    Acknowledgments

    References

    Index

Product details

  • No. of pages: 360
  • Language: English
  • Copyright: © Academic Press 2013
  • Published: July 29, 2013
  • Imprint: Academic Press
  • Hardcover ISBN: 9780124055308
  • eBook ISBN: 9780124055353

About the Editor

M. Hayat

M. Hayat
Dr. Hayat has published extensively in the fields of microscopy, cytology, immunohistochemistry, immunocytochemistry, and antigen retrieval methods. He is Distinguished Professor, Department of Biological Sciences, Kean University, Union, New Jersey, USA.

Affiliations and Expertise

Distinguished Professor, Department of Biological Sciences, Kean University, Union, NJ, USA

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