Description

Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and forward thinking, these books offer a valuable guide to both cellular processes while inciting researchers to explore their potentially important connections.

Considering that autophagy is associated with numerous biological processes, including cellular development and differentiation, cancer (both antitumor and protumor functions), immunity, infectious diseases, inflammation, maintenance of homeostasis, response to cellular stress, and degenerative diseases such as Alzheimer’s, Parkinson's, Huntington's, amyotrophic lateral sclerosis, and prion diseases, there is a great need to understanding its role. Cell homeostasis is achieved by balancing biosynthesis and cellular turnover. In spite of the increasing importance of autophagy in various pathophysiological situations (conditions) mentioned above, this process remains underestimated and overlooked. As a consequence, its role in the initiation, stability, maintenance, and progression of these and other diseases (e.g., autoimmune disease) remains poorly understood.

Volumes in the Series

Volume 1: Molecular Mechanisms. Elucidates autophagy’s association with numerous biological processes, including cellular development and differentiation, cancer, immunity, infectious diseases, inflammation, maintenance of homeostasis, response to cellular stress, and degenerative diseases such as Alzheimer’s, Parkinson's, Huntington's, amyotrophic lateral sclerosis, and prion diseases.
Volume 2: Role in General Diseases. Describes the various aspects of the complex process of autophagy in a myriad of devastating human diseases, expanding from a discussion of essential autophagic functions into the role of autophagy in proteins, pathogens, immunity,

Key Features

  • Presents the most advanced information regarding the role of the autophagic system in life and death and whether autophagy acts fundamentally as a cell survivor or cell death pathway or both
  • Introduces new, more effective therapeutic strategies in the development of targeted drugs and programmed cell death, providing information that will aid on preventing detrimental inflammation
  • States recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities

Readership

Academic/clinical professors, post-doctoral fellows, graduate and medical students in immunology, pathology, infectious diseases, cancer research, oncology, pathology, biology, bioinformatics, endocrinology, gastroenterology, reproductive oncology and public health, industries in drugs development

Table of Contents

Dedication

Dedication

Preface

Contributors

List of Contributions Projected in Volumes 2–4

Abbreviations and Glossary

Chapter 1. Introduction to Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection and Aging, Volumes 1–4

Introduction

Specific Functions of Autophagy (A Summary)

Autophagy in Normal Mammalian Cells

Major Types of Autophagies

Selective Autophagies

Autophagosome Formation

Autophagic Lysosome Reformation

Autophagic Proteins

Protein Degradation Systems

Beclin 1

Non-Autophagic Function of Autophagy-Related Proteins

Microtubule-Associated Protein Light Chain 3

Monitoring Autophagy

Reactive Oxygen Species (ROS)

Mammalian Target of Rapamycin (mTOR)

Role of Autophagy in Tumorigenesis and Cancer

Role of Autophagy in Immunity

Role of Autophagy in Viral Defense and Replication

Role of Autophagy in Intracellular Bacterial Infection

Role of Autophagy in Heart Disease

Role of Autophagy in Neurodegenerative Diseases

Cross-Talk between Autophagy and Apoptosis

References

Part I: General Diseases

Chapter 2. Mechanisms of Regulation of p62 in Autophagy and Implications for Health and Diseases

Introduction

LC3 Recognition by p62

Role of p62 as an Autophagy Receptor

Discussion

References

Chapter 3. Molecular Mechanisms Underlying the Role of Autophagy in Neurodegenerative Diseases

Autophagy Overview and Types

Pathway and Mechanism for Autophagy

Physiological Roles of Autophagy

Autophagy and Neuronal Physiology

Autophagy and Neurodegenerative Diseases

Conclusions and Future Perspective

Acknowledgments

References

Chapter 4. Roles of Multiple Types of Autophagy in Neurodegenerative D

Details

No. of pages:
360
Language:
English
Copyright:
© 2014
Published:
Imprint:
Academic Press
eBook ISBN:
9780124055353
Print ISBN:
9780124055308

About the editor

M. Hayat

Dr. Hayat has published extensively in the fields of microscopy, cytology, immunohistochemistry, immunocytochemistry, and antigen retrieval methods. He is Distinguished Professor, Department of Biological Sciences, Kean University, Union, New Jersey, USA.

Affiliations and Expertise

Distinguished Professor, Department of Biological Sciences, Kean University, Union, NJ, USA

Reviews

"Editor Hayat presents this first volume of a four-volume series on autophagic processes, with an introduction to the series giving a broad overview of autophagy in the healthy state and a selection of disease states. This volume focuses primarily on the role of autophagy in chronic diseases and cancer."--ProtoView.com, February 2014