Autophagy and Metabolism

Autophagy and Metabolism

Potential Target for Cancer Therapy

1st Edition - August 1, 2022

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  • Editors: Dhruv Kumar, Shailendra Asthana
  • Paperback ISBN: 9780323998796

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Description

Autophagy and Metabolism: Potential Target for Cancer Therapy presents updates on autophagy in cancer metabolism and how it can be used to develop new, more efficient treatments. Written by experts in the field, the book presents recent research and explains how to translate it to the clinical setting. Sections discuss tumor cell metabolism and autophagy as therapeutic targets, autophagy regulation in cancer, signaling pathways in metabolic dysregulation in solid tumors, metabolic stress and cell death pathways, and the role of the tumor microenvironment. In addition, topics cover combined targeting autophagy, metabolism for cancer therapy, and the autophagy effect on immune cell metabolism. This will be a valuable resource for researchers, oncologists, graduate students, and members of the biomedical field who are interested in learning more about the interaction between autophagy and cancer metabolism.

Key Features

  • Presents valuable and updated information on the mechanisms of autophagy in cancer metabolism
  • Discusses the various metabolic pathways linked with autophagy that can be a major target for chemotherapeutic strategies
  • Explains how autophagy supports tumor growth by activating metabolic phenotypes in cancer cells and the therapeutic interventions available to halt the process

Readership

Graduate students and researchers on cancer biology. Graduate students and researchers on cancer research in general and oncology

Table of Contents

  • 1. Role of metabolic dysregulation in cancer progression
    2. Role of Autophagy in Cancer Metabolism: Molecular Mechanisms
    3. Tumor Cell Metabolism and Autophagy as Therapeutic Targets
    4. Autophagy Regulation in Cancer: Current Knowledge on Action and Therapy
    5. Signaling pathways in metabolic dysregulation in solid tumors
    6. Metabolic Stress in Autophagy and Cell Death Pathways in Cancer
    7. Role of Tumor Microenvironment in Autophagy and Metabolism in Cancer
    8. Autophagy and Metabolic Regulation in cancer stem cells: molecular mechanisms and therapeutic applications
    9. Mitophagy in cancer and cancer stem cells: a role in metabolic reprogramming
    10. Combined targeting autophagy and metabolism for cancer therapy
    11. Designing metabolic target specific inhibitors for cancer therapy
    12. Effect of autophagy on immune cell metabolism and the effect of metabolites on autophagy activity

Product details

  • No. of pages: 300
  • Language: English
  • Copyright: © Academic Press 2022
  • Published: August 1, 2022
  • Imprint: Academic Press
  • Paperback ISBN: 9780323998796

About the Editors

Dhruv Kumar

Prof. Dhruv Kumar is a Professor at Amity Institute of Molecular Medicine & Stem Cell Research (AIMMSCR), Amity University Uttar Pradesh (AUUP), Noida, and his current research is focused on autophagy, cancer cell metabolism, tumour microenvironment, exosomes, mutational heterogeneity, cancer prevention, drug designing, NGS and COVID-19. After completion of B.Sc. in Chemistry from Banaras Hindu University (BHU) and M.Sc. in Bioinformatics from University of Allahabad, India, he has completed his Ph.D. in Cellular, Molecular and Industrial Biology from the University of Bologna (UNIBO), under highly prestigious fellowship, Indo-Italian Government fellowship. After his Ph.D., he obtained Postdoctoral training at the University of Kansas Medical Center, USA. During his Postdoctoral training, he worked towards understanding the molecular mechanism(s) of autophagy regulation and apoptosis in cancer stem cells (prostate, pancreatic and breast), focusing on the metabolic cross-talk between the tumour microenvironment (cancer associated fibroblast (CAF)) and head and neck squamous cell carcinoma (HNSCC) via HGF/c-MET and bFGF/FGFR signalling pathways. He has also worked on structure based drug designing for several cancers, COVID-19, mutational heterogeneity in cancer. Currently, his lab is focusing on metabolic heterogeneity in solid tumours and structure based drug designing for cancer and COVID-19. He has published more than 80 research articles, reviews and book chapters in reputed journals.

Affiliations and Expertise

Associate Professor, Amity Institute of Molecular Medicine and Stem Cell Research (AIMMSCR), India

Shailendra Asthana

Shailendra Asthana is a Senior Scientist at Translational Health Science and Technology Institute (THSTI), India. He has more than 20 years of research experience in drug discovery, autophagy, and bioinformatics. The goal of his research is to improve atomic level understanding of protein-ligand, protein-nucleic acid, protein-peptide and protein-protein interactions using computational models and tools. Using molecular modeling, molecular docking and physics-based methods such as molecular dynamics simulations, Dr. Asthana and his research group focus on how small molecules interact with proteins and thereby modulate their function.

Affiliations and Expertise

Senior Scientist, Translational Health Science and Technology Institute (THSTI), India

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