Autophagy and Cardiometabolic Diseases - 1st Edition - ISBN: 9780128052532

Autophagy and Cardiometabolic Diseases

1st Edition

From Molecular Mechanisms to Translational Medicine

Paperback ISBN: 9780128052532
Imprint: Academic Press
Published Date: 1st May 2018
Page Count: 340
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Autophagy and Cardiometabolic Diseases: From Moleculer Mechanisms to Translational Medicine covers the science of autophagy in relation to cardiometabolic diseases and the future therapeutic potentials of autophagy regulation in these processes. Processes are not described in isolation, but in concert with other cellular and/or metabolic processes, such as lipogenesis, glucose, energy metabolism and apoptosis. This approach recognizes the multifactorial nature of cardiometabolic diseases, including obesity, diabetes, insulin resistance, hypertension and dyslipidemia. The book provides explanations, while also distinguishing the delicate role for autophagy in pathogenesis and exploring complications for cardiometabolic diseases.

By targeting autophagy, it offers new avenues for drug discovery and treatment for cardiometabolic anomalies. It is a perfect resource for cardiology researchers, scientists and medical practitioners.

Key Features

  • Explains the processes inherent in the protein quality control for pathogenesis and complications of cardiometabolic diseases
  • Provides knowledge from internationally recognized contributors in the field
  • Incorporates a translational approach, covering the basic cellular biology of autophagy and presenting the role of autophagy regulation for both pathogenesis and complication in cardiometabolic diseases
  • Contains access to a companion website with additional illustrations


Researchers from both academia and industry working in the field of cardiovascular disease and biomedical sciences, medical practitioners, pharmaceutical industry workers, and health professional students

Table of Contents

Section I. Cell biology of cardiometabolic syndrome and autophagy
1. Overview of cardiometabolic syndrome
James R. Sowers
2. Overview of autophagy and its molecular regulation
Qing Zhong
3. Interplay among oxidative stress, redox signaling, ER-stress, autophagy and protein ubiquitination
Xuejun Wang and Taixing Cui
4. Selective autophagy for specific organelles
Xiangwei Liu and Jun Ren
5. Experimental models of autophagy and measurement of autophagy
Jian-An Wang
6. Role of autophagy in cardiac physiology and pathophysiology
Shigeki Miyamoto

Section II. Autophagy and pathogenesis of cardiometabolic disease
7. Autophagy and diabetes mellitus
Yingmei Zhang
8. Autophagy and hypertension
Feng Cao
9. Myocardial Insulin Signaling and Autophagy
Thomas Pulinilkunnil and Brian Rodrigues
10. Autophagy and obesity
Jun Ren
11. Autophagy and dyslipidemia
Rajesh Amin
12. Autophagy and stroke
Chao-Yu Miao
13. Polycystic Ovary Syndrome and Cardiometabolic Disease
Shuyi Wang, Amy Navratil and Jun Ren
14. Autophagy and thrombosis, vascular inflammation
Ida Perrotta
15. Autophagy and Proteostasis in Cardiac Aging
Dai Dao-Fu
16. Autophagy and central nervous system
Kenneth Maiese

Section III. Autophagy and complications of cardiometabolic disease
17. Autophagy and chronic liver disease
Jordi Gracia-Sancho
18. Autophagy in acute and chronic kidney disease
M.E. Choi
19. Autophagy and fetal programming
Alina Maloyan
20. Autophagy, oxidative stress and redox regulation
Jian Yang

Section IV. Translational approach of autophagy
21. Therapeutic drug discovery targeting autophagy I
Baharia Mograbi
22. Autophagy: A new therapeutic target
Asli F. Ceylan
23. Autophagy regulates control of intracellular energy stores
Michael N. Sack
24. Autophagy and epigenetics
Zhao V. Wang
25. Autophagy, exercise and life style modification
Donny Camera


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© Academic Press 2018
Academic Press
Paperback ISBN:

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