Autophagy and Cardiometabolic Diseases: From Molecular Mechanisms to Medicine covers the science of autophagy in relation to cardiometabolic diseases and the future therapeutic potentials of autophagy regulation in these processes. The processes within the science of autophagy are not described in isolation but in concert with other cellular and/or metabolic processes such as lipogenesis, glucose and energy metabolism as well as apoptosis. This approach recognizes the multifactorial nature of cardiometabolic diseases including obesity, diabetes, insulin resistance, hypertension and dyslipidemia.
It provides explanation and distinguishes the delicate role for autophagy in the pathogenesis and complications for cardiometabolic diseases. By targeting autophagy, it offers new avenues for drug discovery and treatment for cardiometabolic anomalies, and represents an excellent case for the translational "bench to bedside" research strategy that is developed into effective clinical strategies. Perfect for cardiology researchers, scientists, and medical practitioners, it will serve as an important resource for the understanding of autophagy signaling in basic research to clinical medicine.
- Explains the processes inherent in the protein quality control for pathogenesis and complications of cardiometabolic diseases
- Provides knowledge from internationally recognized contributors in the field, covering the role of autophagy in various components of cardiometabolic diseases
- Incorporates a translational approach, covering the basic cellular biology of autophagy, presenting the role of autophagy regulation for both pathogenesis and complication of cardiometabolic diseases, and discusses how these mechanisms can be targeted for therapeutic regimen for cardiometabolic diseases
- Contains access to a companion website with additional illustrations and cartoons depicting the salient features of book; highlights of each chapter; and clinical trial highlights on autophagy-modulating drugs
Researchers from both academia and industry working in the field of cardiovascular disease and biomedical sciences, medical practitioners, pharmaceutical industry workers, and health professional students
Section I. Cell biology of cardiometabolic syndrome and autophagy
1. Overview of cardiometabolic syndrome
James R. Sowers
2. Overview of autophagy and its molecular regulation
3. Interplay among oxidative stress, redox signaling, ER-stress, autophagy and protein ubiquitination
Xuejun Wang and Taixing Cui
4. Selective autophagy for specific organelles
Xiangwei Liu and Jun Ren
5. Experimental models of autophagy and measurement of autophagy
6. Role of autophagy in cardiac physiology and pathophysiology
Section II. Autophagy and pathogenesis of cardiometabolic disease
7. Autophagy and diabetes mellitus
8. Autophagy and hypertension
9. Myocardial Insulin Signaling and Autophagy
Thomas Pulinilkunnil and Brian Rodrigues
10. Autophagy and obesity
11. Autophagy and dyslipidemia
12. Autophagy and stroke
13. Polycystic Ovary Syndrome and Cardiometabolic Disease
Shuyi Wang, Amy Navratil and Jun Ren
14. Autophagy and thrombosis, vascular inflammation
15. Autophagy and Proteostasis in Cardiac Aging
16. Autophagy and central nervous system
Section III. Autophagy and complications of cardiometabolic disease
17. Autophagy and chronic liver disease
18. Autophagy in acute and chronic kidney disease
19. Autophagy and fetal programming
20. Autophagy, oxidative stress and redox regulation
Section IV. Translational approach of autophagy
21. Therapeutic drug discovery targeting autophagy I
22. Autophagy: A new therapeutic target
Asli F. Ceylan
23. Autophagy regulates control of intracellular energy stores
Michael N. Sack
24. Autophagy and epigenetics
Zhao V. Wang
25. Autophagy, exercise and life style modification
- No. of pages:
- © Academic Press 2018
- 1st May 2018
- Academic Press
- Paperback ISBN:
Dr. Jun Ren is a Professor and Associate Director in University of Wyoming Biomedical PhD Graduate Program. He is a member of American Heart Association and Diabetes Association National Center Study Sections. Dr. Ren specializes in the molecular cardiology with the goal that is to develop a strategy to prevent cardiovascular and a better regimen of treating these disorders. With the PL on several federal or national grants, he has completed enormous researches arming him with experience in cardiac function and structure assessment. In addition, he successfully administered the projects (e.g. staffing, research protections, budget), supervised students, and collaborated with other researchers. His main research interests include Cardiovascular and neurodegenerative diseases.
Associate Dean for Research, Professor, College of Health Sciences Wyoming INBRE Program Director, University of Wyoming, Wyoming, USA
James R. Sowers, MD, is Professor of Medicine, Physiology/Pharmacology and Director of the Endocrinology, Diabetes & Metabolism Division at the University Of Missouri, School Of Medicine. In addition, he is the Director of the Thomas and Joan Burns Cardiovascular and Diabetes Research Center and holds the Thomas W. and Joan F. Burns Missouri Chair in Diabetology. Dr. Sowers serves as a reviewer on several study sections for the National Institutes of Health and for the Department of Veterans Affairs. He is the editor of Cardiorenal Medicine, Associate Editor of Diabetes and on editorial boards of Hypertension, Endocrinology, and Metabolism. In the last year Dr. Sowers has published more than 25 peer-reviewed papers.
Dr. Sowers achieved the Irvin Page Lifetime Achievement Award from the American Heart Association in 2012. He serves as a PI on one NIH funded grant and a VA Merit grant, and is a Co-Investigator on several NIH grants with colleagues at the University of Missouri, as well as other research colleagues at academic institutions around the country.
Dr. Sowers has been examining the cellular mechanisms of insulin action in cardiovascular, renal and skeletal muscle tissue for three decades, focusing primarily on in vitro and in vivo/ex-vivo studies of animal models. Recently his research has been directed to the role of over-nutrition/angiotensin II, aldosterone, estrogen, and immune function on T regulatory cells and in site-specific serine phosphorylation of insulin sensitivity and associated cardiovascular functional abnormalities. As part this continuing cardiovascular renal diabetes research program, his program plans to pursue the role of angiotensin II, aldosterone and sex differences in metabolic cardiovascular insulin resistance in mice subjected to a “Westernized” diet.
Professor of Medicine, Physiology/Pharmacology and Director of the Endocrinology, Diabetes and Metabolism Division, University Of Missouri, School Of Medicine
Yingmei Zhang, M.D., Ph.D. is an Associate Professor and Attending Cardiologist in the Department of Cardiology, Xijing Hospital, the Fourth Military Medical University. She also serves as an adjunct Assistant Professor in the College of Health Science at the University of Wyoming. She received her Master’s and doctoral degrees from the Fourth Military Medical University and completed post-doctoral training at the University of Wyoming. She has over 40 publications in the area of pathogenesis and therapeutics of myocardial dysfunction focusing on the regulation of mitochondrial function and autophagy. Her research has been supported by the Natural Science Foundation of China, National Institute of Health (NIH) and American Diabetes Association (ADA). She serves as an editor or on editorial board for several scientific journals. Her scientific contributions encompass (1) revealing mechanism(s) behind myocardial mitochondrial injury under ER stress; (2) depicting the beneficial role for endogenous myocardial proteins including mitochondrial aldehyde dehydrogenase (ALDH2) and insulin-like growth factor I (IGF-1) under metabolic syndrome.
Associate Professor and Attending Cardiologist, Department of Cardiology, Xijing Hospital, the Fourth Military Medical University