Autoimmunity and the Thyroid

1st Edition - January 1, 1985
Editors: Paul G. Walfish, Jack R. Wall, Robert Volpé
Language: English
eBook ISBN:
9 7 8 - 1 - 4 8 3 2 - 7 3 9 8 - 3

Autoimmunity and the Thyroid is a collection of papers presented at an International Satellite Meeting prior to the 7th International Congress of Endocrinology, held at the Mount… Read more

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Autoimmunity and the Thyroid is a collection of papers presented at an International Satellite Meeting prior to the 7th International Congress of Endocrinology, held at the Mount Sinai Hospital, University of Toronto Medical School on June 29 and 30, 1984. The book provides presentations of participants relating to selected aspects of immune regulation and its role in autoimmune thyroid diseases. Concepts on humoral and cell-mediated immunity mechanisms in the pathogenesis of autoimmune thyroid disease are reviewed; important observations with promising clinical implications in terms of immunogenetics of Graves' and Hashimoto's diseases are presented; and selection of appropriate therapy for Graves' thyrotoxicosis, and the possibility of preventive immunosuppressive and ophthalmopathy therapy are discussed. Endocrinologists, physicians, pathologists, physiologists, and medical researchers will find the book interesting.

Contents

Contributors

Preface

How Thyroid Autoimmunity Was Discovered: Reminiscences of an Autoimmunologist

The Immunogenetic Basis of Autoimmune Thyroid Disease

The Role of HLA-DR in the Pathogenesis of Autoimmune Thyroid Disease

The Role of Human Thyroid Cell la (DR) Antigen in Thyroid Autoimmunity

Quantitative and Qualitative Abnormalities in Circulating Lymphocytes in Autoimmune Thyroid Disease an

Role of Antigen-Specific Suppressor T Lymphocytes in the Pathogenesis of Autoimmune Thyroid Disease

Cytotoxic Mechanisms in Autoimmune Thyroiditis

Humoral Aspects of Graves' Disease

Significance of Thyroid Autoantibodies in Autoimmune Thyroid Diseases

Characterization of Thyroid Autoantibody Synthesizing Cells in Graves' and Hashimoto's Diseases

New Methods of Detecting Thyroid Autoantibodies in Sera and Lymphocyte Sypernatants

Significance of Thyroid Hormone Autoantibodies

New Procedures for Detecting Graves' Immunoglobulins

Structure, Synthesis, Cellular Localization and Immunogenicity of the TSH Receptor

Significance of Remission in Graves' Disease

Postpartum Autoimmune Thyroid Syndromes

Short Communications of Research in Progress

A Longitudinal Study of Thyroid Autoimmunity and Subclinical Hypothyroidism in a Random Population of Central Italy 317

Lithium Therapy Induces Autoimmune Thyroid Disease

Autoimmune Thyroiditis Associated with Melasma in Nonpregnant Women

Detection of Antithyroid Membrane Antibody in Graves' Patients

Relevance of a Circulating Immune Complex Assay (CIC) to Distinguish between Patients with Autoimmune Thyroid Diseases and Healthy Controls

Thyrotropin-Receptor Complex Binding Antibodies in Autoimmune Thyroid Diseases

Thyroid Growth Stimulating Immunoglobulins in Patients of an Iodine-Deficient Goiter Region Estimated by 3H-Thymidine Incorporation into Isolated Porcine Thyroid Follicles

An Antibody to Eye Muscle in Graves' Ophthalmopathy

Analysis of Nonspecific Reaction in Enzyme-Linked Immunosorbent Assay Testing for Human Eye Muscle Specific Antibodies in Graves' Ophthalmopathy and Hashimoto's Thyroiditis

Tissue Cross-Reactivity of Mouse and Human Monoclonal and Polyclonal Antibodies against Human Orbital Tissue Antigens

Decrease of Peripheral Large Granular Lymphocytes in Graves' Disease

T-Suppressor Cell Defects in Sporadic Nontoxic Goiter Disease

Lymphocyte Migration Inhibition in Autoimmune Thyroid Disease Cytotoxicity in Hashimoto's Thyroiditis

Thyroid Antigen-Induced Leukocyte Procoagulant Activity: A Novel Approach to the Study of Cell-Mediated Immunity in Graves' Disease and Hashimoto's Thyroiditis

The Production and Properties of Monoclonal Mouse Antihuman Microsomal Antibodies

Auto- and Heteroantibodies against Human Thyroglobulin Exhibit Similar Heterogeneity and Fine Specificities

Accumulation of Anti-Thyroglobulin (Tg) Antibody by Normal Thyroid Cells of Monolayer Culture

Participation of Ir-gene(s) on the Production of Anti-Thyroid Hormone Antibodies

In Situ Expression of HLA Antigens in Graves' Disease

Immunoglobulin Allotypes and HLA-DR in Diffuse and Multinodular Simple Goiter Disease, Graves' Thyrotoxicosis, and Endocrine Ophthalmopathy

Genetic Markers and Graves' Disease: Study of the Fourth Component Complement Alleles (C4)

HLA-Associated Male Susceptibility to Thyroid Autoantibody Production in a Selected Population

Influence of HLA-DR4 on the Development of Autoimmune Postpartum Thyroiditis

HLA Antigens in Thyroiditis: Differences between Silent and Postpartum Lymphocytic Forms, and Comparison with Subacute and Goitrous Autoimmune Thyroiditis

Rabbits Immunized with TSH Produce Thyroid-Stimulating Antibodies

Identification of Thyroid Autoantigens and Precipitations of the TSH Receptor by Graves' Disease Immunoglobulins

The Development of Monoclonal Antibodies Directed against Anti-TSH Receptor Antibodies

Preparation of Biotinylated Receptor Purified Graves' IgG: A Simple Technique Allowing Direct Functional Assessment of TSH Receptor Antibody Interaction with Membranes

Stimulation of Iodine Organification in Cultured Porcine Thyroid Cells by Graves' Immunoglobulins

Evaluation of Stimulating Effects of Graves' IgG Using Various Thyroid Preparations

Shunichi Yamashita, Motomori Izumi, Fumiko Kakezono,

Demonstration of Heterogeneity in Thyrotropin Displacing (TDI) or Thyroid Stimulating Immunoglobulins (TSI) in Sera of Patients with Graves' Disease by Four Different Assay Methods

An Improved Method for the Detection of Thyroid Hormone Autoantibodies (THAA) in Serum

Two Cases Associated with Thyroid Hormone Autoantibodies

T4 Antibodies and Thyroxine-Binding Globulin (TBG) Immunoradiometric Assay

Production of Anti-Rabbit Thyroglobulin and Antithyroid Hormone Antibodies in Rabbits Immunized with Rabbit Thyroglobulin

Effects of Antithyroid Drugs (MMI and PTU) on Concanavalin A-Induced Suppressor Cell Activity in Studies with Murine Spleen Cells

Correlation of Thyroid Suppressibility and Determination of Thyrotropin Binding Inhibiting Antibodies (TBIAb) at the End of Antithyroid Drug Treatment in Patients with Graves' Disease

Serum Thyroglobulin Levels in Patients with Graves' Disease Treated with Methimazole: Correlation with Thyroid Stimulating and TSH-Binding Inhibiting Immunoglobulins

Relationship of Disease Activity and Altered Balance of Peripheral T Lymphocyte Subsets in Graves' Disease Treated with Thionamide Drugs

TSAb and T Lymphocytes Subset Changes in Patients with Graves' Disease (GD) Treated by Carbimazole (C)

Peripheral T-Lymphocyte Subsets before and during Carbimazole Therapy in Patients with Graves' Disease (GD)

Increase of T8 Cells during Treatment Course and in Remission in a Prospective Study of Medical Treatment for Graves' Disease

Graves' Disease and Hashimoto's Thyroiditis: Effects of High Doses of Antithyroid Drugs on Thyroidal Antibodies

In Vivo Effects of Methimazole and Thyroxine on Thyroid Microsomal Antibody Titers in Hashimoto's Thyroiditis

Prognostic Factors in Graves' Disease

Thyroid Antibodies (TAb) and Outcome of Graves' Disease

Serum 7-Glutamyltranspeptidase (GGT) and Alkaline Phosphatase (ALP): Relation with the Outcome of Graves' Disease

Effect of Partial Thyroidectomy on Antibody Activity in Graves' Disease

Radioiodine Therapy and Serum LATS-Protector

Index