Autoimmunity and the Thyroid

Autoimmunity and the Thyroid

1st Edition - January 1, 1985

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  • Editors: Paul G. Walfish, Jack R. Wall, Robert Volpé
  • eBook ISBN: 9781483273983

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Autoimmunity and the Thyroid is a collection of papers presented at an International Satellite Meeting prior to the 7th International Congress of Endocrinology, held at the Mount Sinai Hospital, University of Toronto Medical School on June 29 and 30, 1984. The book provides presentations of participants relating to selected aspects of immune regulation and its role in autoimmune thyroid diseases. Concepts on humoral and cell-mediated immunity mechanisms in the pathogenesis of autoimmune thyroid disease are reviewed; important observations with promising clinical implications in terms of immunogenetics of Graves' and Hashimoto's diseases are presented; and selection of appropriate therapy for Graves' thyrotoxicosis, and the possibility of preventive immunosuppressive and ophthalmopathy therapy are discussed. Endocrinologists, physicians, pathologists, physiologists, and medical researchers will find the book interesting.

Table of Contents

  • Contents



    How Thyroid Autoimmunity Was Discovered: Reminiscences of an Autoimmunologist

    The Immunogenetic Basis of Autoimmune Thyroid Disease

    The Role of HLA-DR in the Pathogenesis of Autoimmune Thyroid Disease

    The Role of Human Thyroid Cell la (DR) Antigen in Thyroid Autoimmunity

    Quantitative and Qualitative Abnormalities in Circulating Lymphocytes in Autoimmune Thyroid Disease an

    Role of Antigen-Specific Suppressor T Lymphocytes in the Pathogenesis of Autoimmune Thyroid Disease

    Cytotoxic Mechanisms in Autoimmune Thyroiditis

    Humoral Aspects of Graves' Disease

    Significance of Thyroid Autoantibodies in Autoimmune Thyroid Diseases

    Characterization of Thyroid Autoantibody Synthesizing Cells in Graves' and Hashimoto's Diseases

    New Methods of Detecting Thyroid Autoantibodies in Sera and Lymphocyte Sypernatants

    Significance of Thyroid Hormone Autoantibodies

    New Procedures for Detecting Graves' Immunoglobulins

    Structure, Synthesis, Cellular Localization and Immunogenicity of the TSH Receptor

    Significance of Remission in Graves' Disease

    Postpartum Autoimmune Thyroid Syndromes

    Short Communications of Research in Progress

    A Longitudinal Study of Thyroid Autoimmunity and Subclinical Hypothyroidism in a Random Population of Central Italy 317

    Lithium Therapy Induces Autoimmune Thyroid Disease

    Autoimmune Thyroiditis Associated with Melasma in Nonpregnant Women

    Detection of Antithyroid Membrane Antibody in Graves' Patients

    Relevance of a Circulating Immune Complex Assay (CIC) to Distinguish between Patients with Autoimmune Thyroid Diseases and Healthy Controls

    Thyrotropin-Receptor Complex Binding Antibodies in Autoimmune Thyroid Diseases

    Thyroid Growth Stimulating Immunoglobulins in Patients of an Iodine-Deficient Goiter Region Estimated by 3H-Thymidine Incorporation into Isolated Porcine Thyroid Follicles

    An Antibody to Eye Muscle in Graves' Ophthalmopathy

    Analysis of Nonspecific Reaction in Enzyme-Linked Immunosorbent Assay Testing for Human Eye Muscle Specific Antibodies in Graves' Ophthalmopathy and Hashimoto's Thyroiditis

    Tissue Cross-Reactivity of Mouse and Human Monoclonal and Polyclonal Antibodies against Human Orbital Tissue Antigens

    Decrease of Peripheral Large Granular Lymphocytes in Graves' Disease

    T-Suppressor Cell Defects in Sporadic Nontoxic Goiter Disease

    Lymphocyte Migration Inhibition in Autoimmune Thyroid Disease Cytotoxicity in Hashimoto's Thyroiditis

    Thyroid Antigen-Induced Leukocyte Procoagulant Activity: A Novel Approach to the Study of Cell-Mediated Immunity in Graves' Disease and Hashimoto's Thyroiditis

    The Production and Properties of Monoclonal Mouse Antihuman Microsomal Antibodies

    Auto- and Heteroantibodies against Human Thyroglobulin Exhibit Similar Heterogeneity and Fine Specificities

    Accumulation of Anti-Thyroglobulin (Tg) Antibody by Normal Thyroid Cells of Monolayer Culture

    Participation of Ir-gene(s) on the Production of Anti-Thyroid Hormone Antibodies

    In Situ Expression of HLA Antigens in Graves' Disease

    Immunoglobulin Allotypes and HLA-DR in Diffuse and Multinodular Simple Goiter Disease, Graves' Thyrotoxicosis, and Endocrine Ophthalmopathy

    Genetic Markers and Graves' Disease: Study of the Fourth Component Complement Alleles (C4)

    HLA-Associated Male Susceptibility to Thyroid Autoantibody Production in a Selected Population

    Influence of HLA-DR4 on the Development of Autoimmune Postpartum Thyroiditis

    HLA Antigens in Thyroiditis: Differences between Silent and Postpartum Lymphocytic Forms, and Comparison with Subacute and Goitrous Autoimmune Thyroiditis

    Rabbits Immunized with TSH Produce Thyroid-Stimulating Antibodies

    Identification of Thyroid Autoantigens and Precipitations of the TSH Receptor by Graves' Disease Immunoglobulins

    The Development of Monoclonal Antibodies Directed against Anti-TSH Receptor Antibodies

    Preparation of Biotinylated Receptor Purified Graves' IgG: A Simple Technique Allowing Direct Functional Assessment of TSH Receptor Antibody Interaction with Membranes

    Stimulation of Iodine Organification in Cultured Porcine Thyroid Cells by Graves' Immunoglobulins

    Evaluation of Stimulating Effects of Graves' IgG Using Various Thyroid Preparations

    Shunichi Yamashita, Motomori Izumi, Fumiko Kakezono,

    Demonstration of Heterogeneity in Thyrotropin Displacing (TDI) or Thyroid Stimulating Immunoglobulins (TSI) in Sera of Patients with Graves' Disease by Four Different Assay Methods

    An Improved Method for the Detection of Thyroid Hormone Autoantibodies (THAA) in Serum

    Two Cases Associated with Thyroid Hormone Autoantibodies

    T4 Antibodies and Thyroxine-Binding Globulin (TBG) Immunoradiometric Assay

    Production of Anti-Rabbit Thyroglobulin and Antithyroid Hormone Antibodies in Rabbits Immunized with Rabbit Thyroglobulin

    Effects of Antithyroid Drugs (MMI and PTU) on Concanavalin A-Induced Suppressor Cell Activity in Studies with Murine Spleen Cells

    Correlation of Thyroid Suppressibility and Determination of Thyrotropin Binding Inhibiting Antibodies (TBIAb) at the End of Antithyroid Drug Treatment in Patients with Graves' Disease

    Serum Thyroglobulin Levels in Patients with Graves' Disease Treated with Methimazole: Correlation with Thyroid Stimulating and TSH-Binding Inhibiting Immunoglobulins

    Relationship of Disease Activity and Altered Balance of Peripheral T Lymphocyte Subsets in Graves' Disease Treated with Thionamide Drugs

    TSAb and T Lymphocytes Subset Changes in Patients with Graves' Disease (GD) Treated by Carbimazole (C)

    Peripheral T-Lymphocyte Subsets before and during Carbimazole Therapy in Patients with Graves' Disease (GD)

    Increase of T8 Cells during Treatment Course and in Remission in a Prospective Study of Medical Treatment for Graves' Disease

    Graves' Disease and Hashimoto's Thyroiditis: Effects of High Doses of Antithyroid Drugs on Thyroidal Antibodies

    In Vivo Effects of Methimazole and Thyroxine on Thyroid Microsomal Antibody Titers in Hashimoto's Thyroiditis

    Prognostic Factors in Graves' Disease

    Thyroid Antibodies (TAb) and Outcome of Graves' Disease

    Serum 7-Glutamyltranspeptidase (GGT) and Alkaline Phosphatase (ALP): Relation with the Outcome of Graves' Disease

    Effect of Partial Thyroidectomy on Antibody Activity in Graves' Disease

    Radioiodine Therapy and Serum LATS-Protector


Product details

  • No. of pages: 476
  • Language: English
  • Copyright: © Academic Press 1985
  • Published: January 1, 1985
  • Imprint: Academic Press
  • eBook ISBN: 9781483273983

About the Editors

Paul G. Walfish

Jack R. Wall

Robert Volpé

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