Description

Because autoimmune disorders can wreak havoc in both humans and animals, these disorders are now the objects of intense and focused research. This book details specific animal models for a variety of autoimmune disorders. The contributors are recognized authorities who deal with the panoply of experimentally induced autoimmune disorders, including encephalomyelitis, allergic neuritis, uveoretinitis, myocarditis, and hepatitis. Also included are discussions of spontaneously appearing diseases such as autoimmune thyroiditis and systemic lupus erythematosus. Many other disorders are also covered in this comprehensive guide. Certain to be an aid in the planning of individual experiments and broader research programs, this book will be a valuable addition to the library of all practicing immunologists interested in immune system function and dysfunction.

Table of Contents

S. Brocke, K. Gijebels, And L. Steinman, Experimental Autoimmune Encephalomyelitis in the Mouse. A. Alsabbagh and H.L. Weiner, Rat Experimental Autoimmune Encephalomyelitis. S.D. Miller, W.J. Karpus, J.G. Pope, M.C. Dal Canto, And R.W. Melvold, Theiler's Virus-Induced Demyelinating Disease. C. Linington and H. Wekerle, Experimental Allergic Neuritis. R.R. Caspi, Experimental Autoimmune Uveoretinitis (Eau), A. Vincent, Experimental Autoimmune Myasthenia Gravis. G. Wick, R. Cole, H. Dietrich, Ch. Maczek, P.-U. Muller, And K. Hala, The Obese Strain (Os) With Spontaneous Autoimmune Thyroiditis as a Model for Hashimoto Disease. Y.-C.M. Kong and A.A. Giraldo, Experimental Autoimmune Thyroiditis in the Mouse and Rat. D. Elias, The Nod Mouse. P.A. Gottlieb and A.A. Rossini, The Bb Rat Models of Iddm. N.R. Rose and D.A. Neumann, Experimental Myocarditis. A.W. Lohse and K.-H. Meyer Zum Buschenfelde, Experimental Hepatitis. M.H.M. Wauben, J.P.A. Wagenaar-Hilbers, And W. Van Eden, Adjuvant Arthritis. C. Putterman and Y. Naparstek, Murine Models of Spontaneous Systematic Lupus Erythematosus. M.N. Hart and Z. Fabry, Autoimmune Vasculitis. K.S.K. Tung, O. Taguchi, And C. Teuscher, Testicular and Ovarian Autoimmune Diseases. S. Florquin and M . Goldman, Allogenic Diseases. H. Van Herck, V. Baumans, And S.F. De Boer, Assessment of Discomfort in Laboratory Animals.

Details

No. of pages:
329
Language:
English
Copyright:
© 1994
Published:
Imprint:
Academic Press
Print ISBN:
9780121783303
Electronic ISBN:
9780080917368

About the authors

Irun Cohen

Dr. Irun R. Cohen studied philosophy at Northwestern University (B.A., 1959) and medicine at Northwestern Medical School (MD., 1963). He did pediatric training at The Johns Hopkins Hospital and research in infectious diseases as a commissioned officer of the U.S. Public Health Service at the Center for Disease Control in Atlanta, Georgia. Currently, Dr. Cohen is the Director of the Robert Koch-Minerva Center for Research in Autoimmune Diseases, at the Weizmann Institute of Science, in Rehovot, Israel, and the Director of the Center for the Study of Emerging Diseases, in Jerusalem, Israel. He has published numerous scientific journal articles and edited or co-authored 4 books.