Table of Contents

Dedication

Cover image credits

Preface

List of Contributors

Foreword – The concept of immunodiagnosis

Chapter 1. The Concept of Immunodiagnosis

Abstract

Diagnosis of syphilis

Antiphospholipid syndrome

Rheumatoid arthritis

Hemolytic anemias

Systemic lupus erythematosus

Organ-specific autoimmune diseases

Thyroiditis

Receptor diseases

Remarks

References

Part 1: Introduction: Autoantibodies-Unique Characteristics

Chapter 2. What Is an Autoantibody?

Abstract

Introduction

Historical notes

Tolerance and autoimmunity

Concluding remarks

References

Chapter 3. Natural Autoantibodies—Homeostasis, Autoimmunity, and Therapeutic Potential

Abstract

Historical notes

The origin of natural autoantibodies

Natural autoantibodies and their function in autoimmune modulation

Natural autoantibodies as part of the innate immune system

Apoptosis and natural autoantibodies

Protective natural autoantibodies in immune and autoimmune homeostasis

References

Chapter 4. Molecular Mimicry

Abstract

Pathogen infection as a cause for autoimmunity

Examples of true molecular mimicry

The concept of molecular mimicry as a basis for animal models

Molecular mimicry: Protection of the pathogen or the host?

Clinical utilities

Take-home messages

References

Chapter 5. Affinity and Avidity of Autoantibodies

Abstract

Historical notes

Avidity and affinity

Clinical utility of avidity in autoimmune disorders

Take-home messages

References

Chapter 6. Pathogenic Mechanisms and Clinical Relevance of Autoantibodies

Abstract

Historical notes

Pathogenic mechanisms for autoantibody-mediated inju

Details

No. of pages:
916
Language:
English
Copyright:
© 2014
Published:
Imprint:
Elsevier
Print ISBN:
9780444563781
Electronic ISBN:
9780444593771

Reviews

"...a comprehensive reference covering the most important known autoantibodies, with particular emphasis on those that display a clinical value...fully updated to include recent scientific advances, diagnostic techniques and therapeutic technologies."--Anticancer Research, February 2015

"This is an extraordinary, comprehensive, seminal book that is also easy to read. The extensive research of the last few years has advanced the science in dramatic ways and this book has a unique and unmatched presentation of the current understanding of autoantibodies, and their impact on health and disease and begins the discussion of the available treatment options and possibilities for future research."--Doody.com, July 18, 2014


"Almost completely revised and updated…in relation to recent advances in the field, this is the third edition of a textbook describing clinical and research aspects of autoantibodies. Some 150 specific autoantibodies are reviewed, both in terms of their clinical significance to the practicing physician and in relation to research interest in immunoglobulin self-reactivity against tissue antigens."--ProtoView.com, April 2014