3rd Edition

Editors: Yehuda Shoenfeld M. Gershwin
Print ISBN: 9780444563781
eBook ISBN: 9780444593771
Imprint: Elsevier
Published Date: 10th December 2013
Page Count: 916
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Autoimmune diseases are characterized by the occurrence of antibodies reacting with self constituents of the body. This exciting new reference is an exhaustive review of the main autoantibodies identified up to now, with particular emphasis on those autoantibodies that display a clinical value. Each chapter is focussed on a single family of autoantibodies by reviewing their historical notes, definition, origin and source(s) of the antigen(s) recognized, genetic associations, pathogenic mechanisms that are mediated, method(s) of detection and clinical utility (disease prevalence/association, diagnostic value, sensitivity and specificity, prognostic value). An ideal reference for anyone involved in the field of autoimmune diseases.

Table of Contents


Cover image credits


List of Contributors

Foreword – The concept of immunodiagnosis

Chapter 1. The Concept of Immunodiagnosis


Diagnosis of syphilis

Antiphospholipid syndrome

Rheumatoid arthritis

Hemolytic anemias

Systemic lupus erythematosus

Organ-specific autoimmune diseases


Receptor diseases



Part 1: Introduction: Autoantibodies-Unique Characteristics

Chapter 2. What Is an Autoantibody?



Historical notes

Tolerance and autoimmunity

Concluding remarks


Chapter 3. Natural Autoantibodies—Homeostasis, Autoimmunity, and Therapeutic Potential


Historical notes

The origin of natural autoantibodies

Natural autoantibodies and their function in autoimmune modulation

Natural autoantibodies as part of the innate immune system

Apoptosis and natural autoantibodies

Protective natural autoantibodies in immune and autoimmune homeostasis


Chapter 4. Molecular Mimicry


Pathogen infection as a cause for autoimmunity

Examples of true molecular mimicry

The concept of molecular mimicry as a basis for animal models

Molecular mimicry: Protection of the pathogen or the host?

Clinical utilities

Take-home messages


Chapter 5. Affinity and Avidity of Autoantibodies


Historical notes

Avidity and affinity

Clinical utility of avidity in autoimmune disorders

Take-home messages


Chapter 6. Pathogenic Mechanisms and Clinical Relevance of Autoantibodies


Historical notes

Pathogenic mechanisms for autoantibody-mediated inju


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About the Editor

Yehuda Shoenfeld

Prof. Yehuda Shoenfeld is the founder and head of the Zabludowicz Center for Autoimmune Diseases, at the Sheba Medical Center which is affiliated to the Sackler Faculty of Medicine in Tel-Aviv University, in Israel. Dr. Shoenfeld is the Incumbent of the Laura Schwarz-Kipp Chair for Research of Autoimmune Diseases at the Tel-Aviv University. His clinical and scientific works focus on autoimmune and rheumatic diseases, and he has published more than 1750 papers in journals such as New Eng J Med, Nature, Lancet, Proc Nat Acad Scie, J Clin Invest, J Immunol, Blood, FASEB, J Exp Med, Circulation, Cancer and others. His articles have had over 35,000 citations. He has written more than three hundred and fifty chapters in books, and has authored and edited 25 books, some of which became cornerstones in science and clinical practice, such as "The Mosaic of Autoimmunity", "Infections and Autoimmunity" and the textbook "Autoantibodies" and "Diagnostic criteria of autoimmune diseases", all of which were published by Elsevier and sold by the thousands. He is on the editorial board of 43 journals in the field of rheumatology and autoimmunity and is the founder and the editor of the IMAJ (Israel Medical Association Journal) the representative journal of science and medicine in the English language in Israel, and also is the founder and Editor of the "Autoimmunity Reviews" (Elsevier) (Impact factor 7.9) and Co-Editor of "Journal of Autoimmunity" (Impact factor 8.1). He has organized over 20 international congresses in autoimmunity. Prof. Shoenfeld received the EULAR prize in 2005, in Vienna, Austria: "The infectious etiology of anti-phospholipid syndrome". He has received a gold medal from the Slovak Society of Physicians for his contribution to Israel – Slovakia collaboration (March 2006), and is honorary member of the Hungarian Association of Rheumatology. In UC Davis, USA, Dr. Shoenfeld received the Nelson's Prize for Humanity and Science for 2008. In 2009 he was honore

Affiliations and Expertise

Head: Zabludowicz Center for Autoimmune Diseases,Sheba Medical Center, Affiliate of Tel-Aviv University, Israel

M. Gershwin

Affiliations and Expertise

Division of Rheumatology, Allergy & Clinical Immunology, University of California at Davis School of Medicine, Davis, CA


"...a comprehensive reference covering the most important known autoantibodies, with particular emphasis on those that display a clinical value...fully updated to include recent scientific advances, diagnostic techniques and therapeutic technologies."--Anticancer Research, February 2015

"This is an extraordinary, comprehensive, seminal book that is also easy to read. The extensive research of the last few years has advanced the science in dramatic ways and this book has a unique and unmatched presentation of the current understanding of autoantibodies, and their impact on health and disease and begins the discussion of the available treatment options and possibilities for future research.", July 18, 2014

"Almost completely revised and updated…in relation to recent advances in the field, this is the third edition of a textbook describing clinical and research aspects of autoantibodies. Some 150 specific autoantibodies are reviewed, both in terms of their clinical significance to the practicing physician and in relation to research interest in immunoglobulin self-reactivity against tissue antigens.", April 2014