Autoantibodies

Autoantibodies

3rd Edition - November 26, 2013

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  • Editors: Yehuda Shoenfeld, Pier Luigi Meroni, M. Gershwin
  • Hardcover ISBN: 9780444563781
  • eBook ISBN: 9780444593771

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Description

Autoimmune diseases are characterized by the occurrence of antibodies reacting with self-constituents of the body. The fully updated third edition of Autoantibodies is an in-depth review of the main autoantibodies identified up to now, with particular emphasis on those that display a diagnostic or prognostic clinical value. The new edition covers recent scientific advances, diagnostic techniques, and therapeutic technologies. Each chapter is focused on a single family of autoantibodies. This important reference contains historical notes, definitions, origins and sources of antigens recognized genetic associations, mediated pathogenic mechanisms, methods of detection, as well as clinical utility (disease prevalence and association, diagnostic value, sensitivity and specificity, prognostic value). This is an ideal reference for anyone involved in the field of autoimmune diseases.

Key Features

  • Presents all known, important autoantibodies in a single source, focusing on the antibodies needed for autoimmune disorder diagnosis
  • Includes clinical applications for each autoantibody along with general information
  • Organized by disease and disorder type, by autoantibody family, and completely cross-referenced

Readership

Physicians and students in Internal Medicine, Rheumatology, Clinical Immunology, Hematology, Endocrinology, Gastroenterology, Neurology, Nephrology, and Dermatology. Also of interest to those working in companies involved in selling diagnostic assays for autoimmune disorders.

Table of Contents

  • Dedication

    Cover image credits

    Preface

    List of Contributors

    Foreword – The concept of immunodiagnosis

    Chapter 1. The Concept of Immunodiagnosis

    Abstract

    Diagnosis of syphilis

    Antiphospholipid syndrome

    Rheumatoid arthritis

    Hemolytic anemias

    Systemic lupus erythematosus

    Organ-specific autoimmune diseases

    Thyroiditis

    Receptor diseases

    Remarks

    References

    Part 1: Introduction: Autoantibodies-Unique Characteristics

    Chapter 2. What Is an Autoantibody?

    Abstract

    Introduction

    Historical notes

    Tolerance and autoimmunity

    Concluding remarks

    References

    Chapter 3. Natural Autoantibodies—Homeostasis, Autoimmunity, and Therapeutic Potential

    Abstract

    Historical notes

    The origin of natural autoantibodies

    Natural autoantibodies and their function in autoimmune modulation

    Natural autoantibodies as part of the innate immune system

    Apoptosis and natural autoantibodies

    Protective natural autoantibodies in immune and autoimmune homeostasis

    References

    Chapter 4. Molecular Mimicry

    Abstract

    Pathogen infection as a cause for autoimmunity

    Examples of true molecular mimicry

    The concept of molecular mimicry as a basis for animal models

    Molecular mimicry: Protection of the pathogen or the host?

    Clinical utilities

    Take-home messages

    References

    Chapter 5. Affinity and Avidity of Autoantibodies

    Abstract

    Historical notes

    Avidity and affinity

    Clinical utility of avidity in autoimmune disorders

    Take-home messages

    References

    Chapter 6. Pathogenic Mechanisms and Clinical Relevance of Autoantibodies

    Abstract

    Historical notes

    Pathogenic mechanisms for autoantibody-mediated injury

    Clinical relevance

    Take-home messages

    References

    Chapter 7. Predictive Autoantibodies

    Abstract

    Introduction

    Prediction of disease

    Prediction of disease activity and severity

    Autoantibodies as predictors of nonautoimmune diseases

    Hierarchy of autoantibodies

    Combining human leukocyte antigen and predictive antibodies in prediction

    Combining specific genes and antibody testing

    Implications and future directions

    Take-home messages

    References

    Chapter 8. Antibodies Against Acute Phase Proteins

    Abstract

    Historical notes

    The autoantigens

    The autoantibodies

    Clinical utility

    Take-home messages

    References

    Chapter 9. Idiotypes and Anti-Idiotypes

    Abstract

    Historical notes

    The autoantigen

    Structure of idiotypes

    Genetics

    Autoantibodies

    Physiologic role

    Pathogenic role

    Clinical utility

    Summary

    Take-home messages

    References

    Chapter 10. Introductory Remarks for the Diagnostic and Therapeutic Applications of Monoclonal Antibodies and Various Formats

    Abstract

    Monoclonal antibodies

    Antibody engineering

    Clinical applications

    Take-home messages

    References

    Part 2: Allergic Disease Autoantibodies

    Chapter 11. Human Autoantibodies in Urticaria, Angioedema, and Other Atopic Diseases

    Abstract

    Historical notes

    Structure and function

    Immunoglobulin E receptors

    Galectin-3

    Autoantibodies to immunoglobulin E and its receptors

    Clinical utility

    Conclusions

    Take-home messages

    References

    Part 3: Antineutrophil Antibodies

    Chapter 12. Antineutrophil Cytoplasmic Autoantibodies with Specificity for Myeloperoxidase

    Abstract

    Historical notes

    The autoantigen

    The autoantibodies

    Clinical utility

    Take-home messages

    References

    Chapter 13. Antineutrophil Cytoplasmic Antibodies with Specificity for Proteinase 3

    Abstract

    Historical notes

    The autoantigens

    The autoantibodies

    Clinical utility

    Take-home messages

    References

    Chapter 14. Neutrophil-Specific Antinuclear and Anticytoplasmic Autoantibodies in Chronic Inflammatory Diseases

    Abstract

    Historical notes

    Methods of detection

    Standardization of indirect immunofluorescence neutrophil-specific autoantibody detection

    Autoantigens and autoantibodies

    Diagnostic utility of neutrophil-specific autoantibodies

    Diagnostic specificity of neutrophil-specific autoantibodies

    Pathogenicity

    Take-home messages

    References

    Part 4: Introduction: Antinuclear Antibodies

    Chapter 15. Antinuclear Antibodies: General Introduction

    Abstract

    Historical notes

    Methods of antinuclear antibody detection

    Clinical utility

    Open questions on antinuclear antibody testing

    Take-home messages

    References

    Chapter 16. Autoantibodies to Survival of Motor Neuron (SMN) Complex

    Abstract

    Historical note

    Autoantigen

    Autoantibodies

    Clinical utility

    Take-home messages

    References

    Chapter 17. Antinucleolar Antibodies as Diagnostic Markers in Systemic Autoimmune Diseases

    Abstract

    Introduction

    Polymyositis/scleroderma (PM/Scl)

    Th/To

    U3-snoRNP antibodies (fibrillarin)

    B23 (numatrin)

    RNA polymerase antibodies

    NOR-90 (anti-hUBF)

    Other nucleolar autoantigens

    Detection methods

    References

    Chapter 18. Anti-U1RNP and -Sm Antibodies

    Abstract

    Historical notes

    Autoantigens

    Autoantibodies

    Clinical utility

    Take-home messages

    References

    Chapter 19. Antibodies to Rods and Rings

    Abstract

    Historical notes

    Autoantigen

    Autoantibody

    Clinical utility

    Take-home messages

    References

    Chapter 20. Antinucleosome Autoantibodies

    Abstract

    Introduction

    Historical notes

    Autoantigen

    Autoantibody

    Clinical utility

    Take-home messages

    References

    Chapter 21. Centromere Autoantibodies

    Abstract

    Introduction

    Anticentromeres: Methods of detection

    Clinical and demographic associations

    Anticentromeres: Association with other autoantibodies

    Anticentromeres in other connective tissue diseases

    Clinical utility

    Take-home messages

    References

    Chapter 22. dsDNA Autoantibodies

    Abstract

    Historical notes

    Autoantigen

    Autoantibody

    Clinical utility

    Take-home messages

    References

    Chapter 23. Histone Autoantibodies

    Abstract

    Historical notes

    Autoantigens

    Autoantibodies

    Clinical utility

    Take-home messages

    References

    Chapter 24. Ku and Ki Autoantibodies

    Abstract

    Historical notes

    Autoantigens

    Autoantibodies

    Clinical utility

    Take-home messages

    References

    Chapter 25. Neuronal Nuclear Autoantibodies, Type 1 (Hu)

    Abstract

    Introduction

    Historical notes

    Hu antigens

    Anti-Hu autoantibodies

    Hu-ab clinical utility

    Take-home messages

    References

    Chapter 26. Nuclear Envelope Protein Autoantibodies/Antilamin Autoantibodies

    Abstract

    Historical notes

    Autoantigens

    Autoantibodies

    Take-home messages

    References

    Chapter 27. Antiribosomal P Antibodies

    Abstract

    Introduction

    Prevalence

    Characteristics of ribosomal P

    Mechanisms

    Clinical implications

    Conclusion

    References

    Chapter 28. Ro/SSA Autoantibodies

    Abstract

    Historical Notes

    Autoantigen

    Autoantibodies

    Conclusions

    References

    Chapter 29. Topoisomerase I (SCL 70) Autoantibodies

    Abstract

    Acknowledgments

    Historical notes

    Autoantigen

    Autoantibodies

    Clinical utilities

    Take-home messages

    References

    Chapter 30. SS-B (La) Autoantibodies

    Abstract

    Historical notes

    Autoantigen

    Autoantibodies

    Take-home messages

    References

    Part 5: Autoantibodies to Biologic Factors/Structures

    Chapter 31. Autoantibodies to GW/P Bodies and Components of the MicroRNA Pathway

    Abstract

    Historical notes

    Autoantigen

    Autoantibody

    Clinical utility

    Take-home messages

    References

    Chapter 32. Golgi Complex and Endosome Antibodies

    Abstract

    Autoantigen

    Biological function

    Autoantibody

    Clinical utility

    Take-home messages

    References

    Chapter 33. Tumor-Associated Autoantibodies

    Abstract

    Historical notes

    Autoantigenic targets of tumor-associated autoantibodies

    Relevance of tumor-associated autoantibodies

    Tumor-associated autoantibodies – biomarkers for the prediction and early diagnosis of cancer?

    Perspectives

    Take-home messages

    References

    Chapter 34. p53 Autoantibodies

    Abstract

    Historical notes

    Autoantigen

    Autoantibody

    Clinical utility

    Take-home messages

    References

    Chapter 35. Naturally Occurring Anti-HLA-E Autoantibodies: Evidences of HLA-Ia Reactivity of Anti-HLA-E Antibodies

    Abstract

    Introduction

    Anti-HLA-E Abs may account for HLA-Ia reactivity in sera

    Support for the hypothesis from anti-HLA-E IgM/IgG ratios in normal healthy sera

    Direct evidence for immunogenicity of HLA-E in humans

    Anti-HLA-E autoantibodies may account for the nondonor-specific anti-HLA class-Ia antibodies in transplant recipients

    Summary: clinical implications and take-home messages

    References

    Chapter 36. Autoantibodies in Therapeutic Preparations of Human Intravenous Immunoglobulin (IVIg)

    Abstract

    Historical notes

    Maintenance of immune/tissue homeostasis

    Clinical utilities

    Take-home messages

    References

    Chapter 37. Cytoskeletal Autoantibodies/Antiactin Antibodies

    Abstract

    Historical notes

    Autoantigen

    Autoantibody

    Clinical utility

    Take-home messages

    References

    Chapter 38. Fibrillarin Autoantibodies

    Abstract

    Acknowledgments

    Historical notes

    Autoantigen

    Autoantibody

    Clinical utility

    Take-home messages

    References

    Chapter 39. Fibronectin Autoantibodies

    Abstract

    Historical notes

    Autoantigen

    Autoantibody

    Clinical utility

    References

    Chapter 40. IFI16 Autoantibodies

    Abstract

    Historical notes

    Autoantigen

    Autoantibody

    Pathogenetic role

    Clinical utility

    Take-home messages

    References

    Part 6: Cardiac Autoantibodies

    Chapter 41. Heat Shock Protein Autoantibodies

    Abstract

    Heat shock proteins as alarmin

    Molecular mimicry

    Natural autoantibodies

    Immunity against heat shock proteins

    Antiheat shock protein antibodies in vascular diseases

    Take-home messages

    References

    Chapter 42. Antimyocardial Autoantibodies (AMCA)

    Abstract

    Introduction

    Microbial agents implicated in myocardial autoimmunity

    Myocardial autoantigenicity and autoantibodies

    Therapeutic challenges

    Clinical utilities

    Take-home messages

    References

    Part 7: Endocrine Autoantibodies

    Chapter 43. Gastric Autoantibodies

    Abstract

    Historical notes

    Genetics

    Parietal cell autoantigen

    Parietal cell autoantibodies

    Intrinsic factor autoantigen

    Intrinsic factor autoantibodies

    Clinical utility

    Take-home messages

    References

    Chapter 44. Thyroid Autoantibodies: Thyroid Peroxidase and Thyroglobulin Antibodies

    Abstract

    Historical note

    Thyroid peroxidase autoantibodies

    Thyroglobulin autoantibodies

    Clinical utilities

    Take-home messages

    References

    Chapter 45. Thyrotropin Receptor Antibodies

    Abstract

    Autoantigen

    Autoantibody

    Take-home messages

    References

    Chapter 46. Glutamic Acid Decarboxylase Antibody

    Abstract

    Historical notes

    Autoantigen

    Autoantibodies

    Use in clinical practice

    Take-home messages

    References

    Chapter 47. Antibodies to Gonadal and Adrenal Tissue

    Abstract

    Introduction

    Antibodies to ovary and testes

    Autoantibodies against adrenal cortex

    Conclusion

    Take-home messages

    References

    Chapter 48. Humoral Immunity in Type 1 Diabetes Mellitus

    Abstract

    Historical notes

    Autoantigen

    Autoantibody

    Clinical utility

    Take-home messages

    References

    Part 8: Gi and Liver Autoantibodies

    Chapter 49. Autoantibody Profile in Inflammatory Bowel Disease

    Abstract

    Introduction

    Historical notes

    Autoantibodies in inflammatory bowel disease

    Glycoprotein 2-specific pancreatic autoantibodies

    Intestinal goblet cell autoantibodies

    Additional autoantibodies

    Clinical utility of the main autoantibodies in inflammatory bowel disease

    Conclusions

    Take-home messages

    References

    Chapter 50. Anti-Intestinal Goblet Cell Antibodies

    Abstract

    Historical notes

    Autoantigen

    Autoantibody

    Clinical utility

    Take-home messages

    References

    Chapter 51. Antipancreatic Autoantibodies

    Abstract

    Historical notes

    Autoantigen

    Autoantibody

    Clinical utility

    Take-home messages

    References

    Chapter 52. Cryoglobulins and Cryoglobulins Secondary to Hepatitis C Virus Infection

    Abstract

    Introduction

    Cryoglobulins and hepatitis C virus

    Mixed cryoglobulinemia syndrome

    Take-home messages

    References

    Chapter 53. Autoantibodies in Autoimmune Hepatitis

    Abstract

    Historical notes

    Antinuclear antibodies

    Antismooth muscle antibodies

    Anti-liver-kidney-microsomal antibodies

    Autoantibody testing in autoimmune hepatitis

    Autoantibodies in autoimmune hepatitis

    Clinical utilities

    Take-home messages

    References

    Chapter 54. Antitissue Transglutaminase and Antiendomysial Antibodies

    Abstract

    Historical notes

    Autoantigen

    Autoantibody

    Clinical utility

    Take-home messages

    References

    Chapter 55. Antigliadin and Antideamidated Gliadin Peptide Antibodies

    Abstract

    Historical notes

    The antigen

    The antibody

    Clinical utility

    Take-home messages

    References

    Chapter 56. Liver Cytosol Antigen Type 1 Autoantibodies (LC-1), Liver Kidney Microsomal Autoantibodies (LKM), and Liver Microsomal Autoantibodies (LM)

    Abstract

    Liver kidney microsomal/liver microsomal autoantibodies, targets, and definitions

    Clinical utility of liver kidney microsomal/liver microsomal autoantibodies

    Microsomal autoantibodies in hepatitis C virus infection

    Hepatitis D virus-associated liver kidney microsomal autoantibodies (LKM-3)

    Liver cytosolic autoantibodies (LC1)

    Clinical utility

    Take-home messages

    References

    Chapter 57. Antimitochondrial Antibodies

    Abstract

    Historical notes

    Autoantigens

    Autoantibodies

    Use in clinical practice

    Antimitochondrial antibodies and other autoantibodies

    Take-home messages

    References

    Chapter 58. Smooth Muscle Autoantibodies

    Abstract

    Historical notes

    The autoantigens

    The autoantibodies

    Clinical utility

    Take-home messages

    References

    Part 9: Hematologic Autoantibodies

    Chapter 59. Coagulation Factor Autoantibodies

    Abstract

    Introduction

    Historical notes

    Autoantibodies against coagulation factors

    Laboratory tests

    Clinical utilities

    Take-home messages

    References

    Chapter 60. Autoantibodies in Heparin-Induced Thrombocytopenia

    Abstract

    Historical notes

    Autoantigen: the platelet factor 4/heparin complex

    Autoantibody

    Clinical utility

    Take-home messages

    References

    Chapter 61. Platelet Autoantibodies

    Abstract

    Historical notes

    Platelet autoantigens

    Platelet autoantibodies

    Clinical utility

    Take-home messages

    References

    Chapter 62. Red Cell Autoantibodies

    Abstract

    Introduction

    Pathogenic role of anti-red blood cell antibodies

    Detection of anti-red blood cell antibodies

    Drug-induced anti-red blood cell antibodies

    Anti-red blood cell antibodies and hematopoietic stem cell transplantation

    Clinical utility

    Take-home messages

    References

    Chapter 63. Lymphocytotoxic Autoantibodies

    Abstract

    Historical notes

    The autoantigens

    The autoantibodies

    Clinical utility

    Take-home messages

    References

    Part 10: Kidney Autoantibodies

    Chapter 64. Anti-Phospholipase A2 Receptor Autoantibodies

    Abstract

    Historical notes

    Autoantigen

    Autoantibody

    Method of detection

    Clinical utility

    Other autoantibodies in idiopathic membranous nephritis

    Take-home messages

    References

    Chapter 65. Glomerular Basement Membrane Autoantibodies

    Abstract

    Historical notes

    Autoantigen

    Autoantibodies

    Clinical utility

    Take-home messages

    References

    Chapter 66. Nephritic Factor Autoantibodies

    Abstract

    Historical notes

    The autoantigen

    Autoantibodies

    Clinical utility

    Take-home messages

    References

    Chapter 67. IgA Nephropathies

    Abstract

    Introduction

    Pathogenesis of IgAN

    Aberrant glycosylation (galactose-deficiency) of IgA1

    Dysregulated immune response

    Synthesis of glycan-specific antibodies against galactose-deficient IgA1 and formation of pathogenic IgA1-containing immune complexes

    Mesangial deposition of IgA1-containing immune complexes, inflammation, and renal injury

    Conclusions

    Clinical utilities

    Take-home messages

    References

    Part 11: Neurological System Autoantibodies

    Chapter 68. Acetylcholine Receptor and Muscle-Specific Kinase Autoantibodies

    Abstract

    Historical notes

    The autoantigen

    The autoantibody

    Clinical utility

    Low density lipoprotein receptor-related protein 4

    Take-home messages

    References

    Chapter 69. Human Anti-Glycosphingolipids Antibodies in Guillain-Barré Syndrome

    Abstract

    Acknowledgment

    Introduction

    Guillain-Barré syndrome and its variant neuropathies

    Molecular species diversity of anti-glycosphingolipid antibodies in Guillain-Barré syndrome and its variants

    Anti-ganglioside complex antibodies in Guillain-Barré syndrome and its variants

    Anti-sulfoglycolipid antibodies

    Molecular mimicry

    Anti-glycolipid antibody target sites in the peripheral nerve

    Interspecies transmission of Guillain-Barré syndrome

    Concluding remarks

    References

    Chapter 70. Central Nervous System Neuronal Surface Antibodies

    Abstract

    Historical notes

    Voltage-gated potassium channel complex antibodies

    N-methyl-D-aspartate receptor antibodies

    Alfa-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid receptor antibodies

    Gamma-aminobutyric acid B-receptor antibodies

    Glycine receptor antibodies

    Other central nervous system neuronal surface antibodies

    Metabotropic glutamate receptor 5 (MGLUR5) antibodies

    Dipeptidyl-peptidase-like protein-6 (DPPX) antibodies

    Dopamine 2 receptor antibodies

    Take-home messages

    References

    Chapter 71. Antibodies to AQP4

    Abstract

    Historical notes

    Autoantigens

    Autoantibodies

    Clinical utility

    Autoimmune, autoantibody, and cancer accompaniments

    Take-home messages

    References

    Chapter 72. Myositis Autoantibodies

    Abstract

    Historical notes

    The autoantigens

    The autoantibodies

    Clinical utility

    Take-home messages

    References

    Chapter 73. Myelin Oligodendrocyte Glycoprotein (MOG): An Archetypal Target for Demyelinating Autoantibodies in the Central Nervous System

    Abstract

    Acknowledgments

    Introduction

    MOG – an archetypal target for demyelinating autoantibodies in the central nervous system

    Defining the epitope specificity of demyelinating MOG-specific autoantibodies

    IgG responses do not exist in isolation: functional significance of the T-cell response in MOG-induced EAE

    More than antibodies: B-cell function in MOG-induced EAE

    MOG-specific antibodies in human disease

    Concluding remarks

    Take-home messages

    References

    Chapter 74. Autoantibodies in the Lambert-Eaton Myasthenic Syndrome (LEMS) and Amyotrophic Lateral Sclerosis (ALS)

    Abstract

    Historical notes

    Autoantibodies in Lambert-Eaton myasthenic syndrome

    Autoantibodies in amyotrophic lateral sclerosis

    References

    Chapter 75. Antimyelin-Associated Glycoprotein, Antimyelin Basic Protein, and Antiproteolipid Autoantibodies in Neurologic Diseases

    Abstract

    Introduction

    Antimyelin antibodies in multiple sclerosis and its animal model experimental autoimmune encephalomyelitis

    Antimyelin basic protein antibodies in multiple sclerosis

    Antiproteolipid protein antibodies in multiple sclerosis

    Antimyelin-associated glycoprotein antibodies in multiple sclerosis

    Antimyelin antibodies as biomarkers of disease progression in multiple sclerosis

    Antimyelin antibodies in other neurologic disease

    Antimyelin antibodies and peripheral neuropathy

    Conclusions

    References

    Chapter 76. Paraneoplastic Neurologic Antibodies

    Abstract

    Introduction

    Historical notes

    Classic paraneoplastic neurologic syndromes

    Autoantibodies, antigens, and clinical utility

    Antinuclear antibodies

    Cytoplasmic paraneoplastic antibodies and antigens

    Cell surface receptor antibodies

    Take-home messages

    References

    Chapter 77. Retinal Autoantibodies

    Abstract

    Historical notes

    Clinical features and diagnostic workup

    Pathophysiology

    Diagnostic testing for antiretinal antibodies

    Treatment

    Clinical utilities

    Take-home messages

    References

    Part 12: Rheumatic Disease Autoantibodies

    Chapter 78. Antifodrin Antibodies

    Abstract

    Autoantigen

    Autoantibody

    Clinical utility

    Diagnostic value

    Organ involvement/damage

    Take-home messages

    References

    Chapter 79. Antibodies to Laminin

    Abstract

    Historical notes

    Autoantigen

    Autoantibody

    Clinical utility

    Take-home messages

    References

    Chapter 80. Autoantibodies Against Muscarinic Acetylcholine Receptor in Patients with Sjögren Syndrome

    Abstract

    Acknowledgment

    Historical notes

    Autoantigen

    Autoantibody

    Clinical utility

    Conclusions

    References

    Chapter 81. β2-Glycoprotein I Autoantibodies

    Abstract

    Historical notes

    The β2GPI autoantigen: definition

    β2GPI biologic functions

    Source and methods of β2GPI purification

    β2-GPI in atherogenesis

    The β2GPI autoantibody: definition

    Pathogenic role

    Newer pathogenic roles

    Method of detection

    Clinical utility: disease association

    Diagnostic value

    Take-home messages

    References

    Chapter 82. C1 Inhibitor Autoantibodies

    Abstract

    Historical notes

    Autoantigen

    Autoantibody

    Clinical utility

    Take-home messages

    References

    Chapter 83. Autoantibodies to C1q

    Abstract

    Historical notes

    Autoantigen

    Autoantibody

    Clinical utility

    Conclusions

    Take-home messages

    References

    Chapter 84. Anticollagen Antibodies

    Abstract

    Historical notes

    Collagen as an autoantigen

    Autoantibody

    Clinical utility

    Take-home messages

    References

    Chapter 85. Antiendothelial Cell Antibodies

    Abstract

    Historical notes

    Natural antiendothelial cell antibodies

    Pathologic antiendothelial cell antibodies

    Clinical utility

    Take-home messages

    References

    Chapter 86. Lupus Anticoagulant Testing

    Abstract

    Historical notes

    Autoantigen

    Autoantibody

    Criteria for the diagnosis of lupus anticoagulant

    Clinical utility

    Take-home messages

    References

    Chapter 87. Anticardiolipin Antibodies

    Abstract

    Historical notes

    Autoantigens

    Autoantibodies

    Genetics

    Methods of detection

    Clinical utility

    Take-home messages

    References

    Chapter 88. Phospholipid Autoantibodies (Nonanticardiolipin)-Antiprothrombin Antibodies

    Abstract

    Historical notes

    Antigenic target

    Detection methods

    Mechanisms of action

    Antiprothrombin in autoimmune diseases

    Clinical association

    Clinical utilities

    Take-home messages

    References

    Chapter 89. Rheumatoid Factors

    Abstract

    Historical notes

    Autoantigen

    Autoantibodies

    Clinical utility

    Take-home messages

    References

    Chapter 90. Antibodies to Specific Citrullinated Proteins in Rheumatoid Arthritis

    Abstract

    Historical notes

    Identification of specific citrullinated proteins as autoantigens

    Role of specific anticitrullinated protein/peptide antibody in pathogenesis

    Peptide-based assays for anticitrullinated protein/peptide antibody fine specificity

    Clinical utilities

    Take-home messages

    References

    Part 13: Skin Disease Autoantibodies

    Chapter 91. Autoantibodies to Mucocutaneous Antigens

    Abstract

    Epidermis, dermis, and in between

    Type II mucocutaneous autoimmunity: epidermal antigens

    Type II mucocutaneous autoimmunity: dermal antigens

    Conclusions

    Take-home messages

    References

    Part 14: Unique Clinical Situations

    Chapter 92. Autoimmunity and the Newer Biopharmaceuticals

    Abstract

    Introduction

    Autoimmunity

    Conclusions

    References

    Chapter 93. Antibodies Against “Human” Biopharmaceuticals: Individualized Therapy with TNF-alpha Inhibitors Guided by Immunopharmacologic Assessments

    Abstract

    Historical notes

    Biopharmaceuticals

    Use of anti-tumor necrosis factor-alpha biopharmaceuticals

    Clinical response types to tumor necrosis factor-inhibitors

    Pharmacoimmunology of anti-tumor necrosis factor-alpha biopharmaceuticals

    Monitoring patients for anti-drug antibodies

    Assessments of drug bioavailability and immunogenicity

    Novel techniques for monitoring anti-drug antibodies during anti-tumor necrosis factor-alpha therapies

    Clinical utilities

    Take-home messages

    References

    Chapter 94. Autoantibodies and Pregnancy Loss

    Abstract

    Historical notes

    Autoantigens

    Autoantibodies

    Clinical utility

    Take-home messages

    References

    Chapter 95. Autoantibodies – Future Trends

    Abstract

    Background

    The past

    The present

    The future

    Take-home messages

    References

    Index

Product details

  • No. of pages: 916
  • Language: English
  • Copyright: © Elsevier 2013
  • Published: November 26, 2013
  • Imprint: Elsevier
  • Hardcover ISBN: 9780444563781
  • eBook ISBN: 9780444593771

About the Editors

Yehuda Shoenfeld

Yehuda Shoenfeld
President of the Center for Autoimmune diseases (Present). Incumbent of the Laura Schwarz-Kipp Chair for Research of Autoimmune Diseases in Tel-Aviv University (since 2002 – Present). Emeritus Professor of the Sackler School of Medicine in Tel-Aviv University, and teaches medical studies and MSc, & PhD students (since 1985). Prof. Shoenfeld edited series of Textbooks entailing "The Mosaic of Autoimmunity", Textbook on "Autoantibodies", "Infection and autoimmunity", and "Diagnostic criteria of Autoimmune Diseases".(Elsevier Pub.) On 36 Editorial Boards, and the organizer of more than 25 international congresses on Autoimmunity. Author of > 2000 peer review papers reported in the field of autoimmunity and internal medicine. More than 65,000 citations.

Affiliations and Expertise

Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Affiliate of Tel-Aviv University, Israel

Pier Luigi Meroni

Pier Luigi Meroni

Affiliations and Expertise

Department of Clinical Sciences & Community Health, University of Milan, Italy

M. Gershwin

M. Gershwin

Affiliations and Expertise

Division of Rheumatology, Allergy & Clinical Immunology, University of California at Davis School of Medicine, Davis, CA

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