Autoantibodies

2nd Edition

Editors: Yehuda Shoenfeld Pier Luigi Meroni M. Gershwin M.E. Gershwin Pier Luigi Meroni Yehuda Shoenfeld
Hardcover ISBN: 9780444527639
eBook ISBN: 9780080467238
Imprint: Elsevier Science
Published Date: 17th November 2006
Page Count: 872
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Description

Autoantibodies was published and presented in November 2006 at the International Congress of Autoimmunity in Sorrento, a small town in Campania, Italy. The Congress also celebrated the 100th anniversary of the first routine test for autoantibodies. An autoantibody is a type of antibody that is produced by the immune system and that fights one or more of a person’s own proteins. These autoantibodies cause autoimmune diseases such as lupus erythematosus.
The authors and editors of this book provide a critical review of autoantibodies and their primary functions. They cite a number of major developments in the field of autoantibodies, including the detection of autoantibodies in which a healthy person is a carrier; the discovery that autoantibodies can be both pathogenic and protective in some cases; and the development of a device that will help monitor and detect a specific autoantibody using a small amount of serum and proteomic arrays. Aside from the pathogenic and protective autoantibodies, the book also discusses irrelevant autoantibodies, as these may be relevant for future research. It also addresses the importance of the autoantibodies in a person’s body.
Clinical physicians, as well as scientists interested in the significance of autoantibodies in the human body, will find this book relevant. It will also be of interest to those who suffer from an autoimmune disease.

Key Features

  • Incudes and exhaustive list of autoantibodies not covered by other publications
  • Short reviews can easily be checked for quick reference information
  • Both basic and clinical aspects are covered

Readership

Physicians and students in Internal Medicine, Rheumatology, Clinical Immunology, Hematology, Endocrinology, Gastroenterology, Neurology, Nephrology, and Dermatology. Also of interest to those working in companies involved in selling diagnostic assays for autoimmune disorders.

Table of Contents

Foreword Autoantibodies: History and Horizons Preface About the Editors List of Contributors Introduction I Introduction: Autoantibodies-Unique Characteristics 1 What is an Autoantibody? 2 Natural Autoantibodies, Heralding, Protecting and Inducing Autoimmunity 3 Molecular Mimicry 4 Affinity and Avidity of Autoantibodies 5 Pathogenic Mechanisms and Clinical Relevance of Autoantibodies 6 Native Autoantigens Versus Recombinant Autoantigens 7 Redox-Reactive Autoantibodies 8 Predictive Autoantibodies 9 Autoantibody Subclasses 10 Idiotypes and Anti-Idiotypes 11 Novel Diagnostic Methods for Autoantibody Detection II Allergic Disease Autoantibodies 12 Human IgE–Specific Autoantibodies and Autoantibodies to IGE Receptors III Antineutrophil Antibodies 13 Antineutrophil Cytoplasmic Autoantibodies with Specificity for Myeloperoxidase 14 Antineutrophil Cytoplasmic Autoantibodies with Specificity for Proteinase 3 15 Neutrophil-Specific Antinuclear and Anti-cytoplasmic Antibodies in Chronic Inflammatory Diseases 16 Antineutrophil Cytoplasmatic Autoantibodies with Specificity to Proteinase 3 IV Introduction: Antinuclear Antibodies 17 Antinuclear Antibodies: General Introduction 18 Antinucleolar Antibodies 19 Anti-Chromatin (Nucleosome) Autoantibodies 20 Centromere Autoantibodies 21 dsDNA Autoantibodies 22 Histone Autoantibodies 23 Ku and Ki Autoantibodies 24 Neuronal Nuclear Autoantibodies, Type 1 (HU) 25 Nuclear Envelope Protein Autoantibodies/Antilamin Autoantibodies 26 Anti-Nucleosome Autoantibodies 27 Proliferating Cell Nuclear Antigen Autoantibodies 28 Anti-RA33 Antibodies (Antibodies to the Heterogeneous Nuclear Ribonucleoprotein A2) 29 Anti-Ribosomal P Antibodies 30 SS-A (Ro) Autoantibodies 31 Topoisomerase-I (Scl-70) Autoantibodies 32 SS-B (La) Autoantibodies 33 Anti-RNA Polymerase III Antibodies V

Details

No. of pages:
872
Language:
English
Copyright:
© Elsevier Science 2007
Published:
Imprint:
Elsevier Science
eBook ISBN:
9780080467238
Hardcover ISBN:
9780444527639

About the Editor

Yehuda Shoenfeld

Prof. Yehuda Shoenfeld is the founder and head of the Zabludowicz Center for Autoimmune Diseases, at the Sheba Medical Center which is affiliated to the Sackler Faculty of Medicine in Tel-Aviv University, in Israel. Dr. Shoenfeld is the Incumbent of the Laura Schwarz-Kipp Chair for Research of Autoimmune Diseases at the Tel-Aviv University. His clinical and scientific works focus on autoimmune and rheumatic diseases, and he has published more than 1750 papers in journals such as New Eng J Med, Nature, Lancet, Proc Nat Acad Scie, J Clin Invest, J Immunol, Blood, FASEB, J Exp Med, Circulation, Cancer and others. His articles have had over 35,000 citations. He has written more than three hundred and fifty chapters in books, and has authored and edited 25 books, some of which became cornerstones in science and clinical practice, such as "The Mosaic of Autoimmunity", "Infections and Autoimmunity" and the textbook "Autoantibodies" and "Diagnostic criteria of autoimmune diseases", all of which were published by Elsevier and sold by the thousands. He is on the editorial board of 43 journals in the field of rheumatology and autoimmunity and is the founder and the editor of the IMAJ (Israel Medical Association Journal) the representative journal of science and medicine in the English language in Israel, and also is the founder and Editor of the "Autoimmunity Reviews" (Elsevier) (Impact factor 7.9) and Co-Editor of "Journal of Autoimmunity" (Impact factor 8.1). He has organized over 20 international congresses in autoimmunity. Prof. Shoenfeld received the EULAR prize in 2005, in Vienna, Austria: "The infectious etiology of anti-phospholipid syndrome". He has received a gold medal from the Slovak Society of Physicians for his contribution to Israel – Slovakia collaboration (March 2006), and is honorary member of the Hungarian Association of Rheumatology. In UC Davis, USA, Dr. Shoenfeld received the Nelson's Prize for Humanity and Science for 2008. In 2009 he was honore

Affiliations and Expertise

Head: Zabludowicz Center for Autoimmune Diseases,Sheba Medical Center, Affiliate of Tel-Aviv University, Israel

Pier Luigi Meroni

Affiliations and Expertise

Department of Clinical Sciences & Community Health, University of Milan, Italy

M. Gershwin

Affiliations and Expertise

Division of Rheumatology, Allergy & Clinical Immunology, University of California at Davis School of Medicine, Davis, CA

M.E. Gershwin

Affiliations and Expertise

University of California, Clinical Division of Rheumatology, School of Medicine, Davis, CA, USA

Pier Luigi Meroni

Affiliations and Expertise

Department of Clinical Sciences & Community Health, University of Milan, Italy

Yehuda Shoenfeld

Prof. Yehuda Shoenfeld is the founder and head of the Zabludowicz Center for Autoimmune Diseases, at the Sheba Medical Center which is affiliated to the Sackler Faculty of Medicine in Tel-Aviv University, in Israel. Dr. Shoenfeld is the Incumbent of the Laura Schwarz-Kipp Chair for Research of Autoimmune Diseases at the Tel-Aviv University. His clinical and scientific works focus on autoimmune and rheumatic diseases, and he has published more than 1750 papers in journals such as New Eng J Med, Nature, Lancet, Proc Nat Acad Scie, J Clin Invest, J Immunol, Blood, FASEB, J Exp Med, Circulation, Cancer and others. His articles have had over 35,000 citations. He has written more than three hundred and fifty chapters in books, and has authored and edited 25 books, some of which became cornerstones in science and clinical practice, such as "The Mosaic of Autoimmunity", "Infections and Autoimmunity" and the textbook "Autoantibodies" and "Diagnostic criteria of autoimmune diseases", all of which were published by Elsevier and sold by the thousands. He is on the editorial board of 43 journals in the field of rheumatology and autoimmunity and is the founder and the editor of the IMAJ (Israel Medical Association Journal) the representative journal of science and medicine in the English language in Israel, and also is the founder and Editor of the "Autoimmunity Reviews" (Elsevier) (Impact factor 7.9) and Co-Editor of "Journal of Autoimmunity" (Impact factor 8.1). He has organized over 20 international congresses in autoimmunity. Prof. Shoenfeld received the EULAR prize in 2005, in Vienna, Austria: "The infectious etiology of anti-phospholipid syndrome". He has received a gold medal from the Slovak Society of Physicians for his contribution to Israel – Slovakia collaboration (March 2006), and is honorary member of the Hungarian Association of Rheumatology. In UC Davis, USA, Dr. Shoenfeld received the Nelson's Prize for Humanity and Science for 2008. In 2009 he was honore

Affiliations and Expertise

Zabludowicz Center for Autoimmune Diseases,Sheba Medical Center, Affiliate of Tel-Aviv University, Israel

Reviews

Autoantibodies was published and presented in November 2006 at the International Congress of Autoimmunity in Sorrento, a small town in Campania, Italy. The Congress also celebrated the 100th anniversary of the first routine test for autoantibodies. An autoantibody is a type of antibody that is produced by the immune system and that fights one or more of a person’s own proteins. These autoantibodies cause autoimmune diseases such as lupus erythematosus. The authors and editors of this book provide a critical review of autoantibodies and their primary functions. They cite a number of major developments in the field of autoantibodies, including the detection of autoantibodies in which a healthy person is a carrier; the discovery that autoantibodies can be both pathogenic and protective in some cases; and the development of a device that will help monitor and detect a specific autoantibody using a small amount of serum and proteomic arrays. Aside from the pathogenic and protective autoantibodies, the book also discusses irrelevant autoantibodies, as these may be relevant for future research. It also addresses the importance of the autoantibodies in a person’s body. Clinical physicians, as well as scientists interested in the significance of autoantibodies in the human body, will find this book relevant. It will also be of interest to those who suffer from an autoimmune disease.