2nd Edition - November 27, 2006

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  • Editors: Yehuda Shoenfeld, Pier Luigi Meroni, M. Gershwin, M.E. Gershwin, Y. Shoenfeld
  • eBook ISBN: 9780080467238

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Autoantibodies was published and presented in November 2006 at the International Congress of Autoimmunity in Sorrento, a small town in Campania, Italy. The Congress also celebrated the 100th anniversary of the first routine test for autoantibodies. An autoantibody is a type of antibody that is produced by the immune system and that fights one or more of a person’s own proteins. These autoantibodies cause autoimmune diseases such as lupus erythematosus. The authors and editors of this book provide a critical review of autoantibodies and their primary functions. They cite a number of major developments in the field of autoantibodies, including the detection of autoantibodies in which a healthy person is a carrier; the discovery that autoantibodies can be both pathogenic and protective in some cases; and the development of a device that will help monitor and detect a specific autoantibody using a small amount of serum and proteomic arrays. Aside from the pathogenic and protective autoantibodies, the book also discusses irrelevant autoantibodies, as these may be relevant for future research. It also addresses the importance of the autoantibodies in a person’s body. Clinical physicians, as well as scientists interested in the significance of autoantibodies in the human body, will find this book relevant. It will also be of interest to those who suffer from an autoimmune disease.

Key Features

  • Incudes and exhaustive list of autoantibodies not covered by other publications
  • Short reviews can easily be checked for quick reference information
  • Both basic and clinical aspects are covered


Physicians and students in Internal Medicine, Rheumatology, Clinical Immunology, Hematology, Endocrinology, Gastroenterology, Neurology, Nephrology, and Dermatology. Also of interest to those working in companies involved in selling diagnostic assays for autoimmune disorders

Table of Contents

  • I Introduction: Autoantibodies-Unique Characteristics
    1 What is an Autoantibody?
    2 Natural Autoantibodies, Heralding, Protecting and Inducing Autoimmunity
    3 Molecular Mimicry
    4 Affinity and Avidity of Autoantibodies
    5 Pathogenic Mechanisms and Clinical Relevance of Autoantibodies
    6 Native Autoantigens Versus Recombinant Autoantigens
    7 Redox-Reactive Autoantibodies
    8 Predictive Autoantibodies
    9 Autoantibody Subclasses
    10 Idiotypes and Anti-Idiotypes
    11 Novel Diagnostic Methods for Autoantibody Detection

    II Allergic Disease Autoantibodies
    12 Human IgE–Specific Autoantibodies and Autoantibodies to IGE Receptors

    III Antineutrophil Antibodies
    13 Antineutrophil Cytoplasmic Autoantibodies with Specificity for Myeloperoxidase
    14 Antineutrophil Cytoplasmic Autoantibodies with Specificity for Proteinase 3
    15 Neutrophil-Specific Antinuclear and Anti-cytoplasmic Antibodies in Chronic Inflammatory Diseases
    16 Antineutrophil Cytoplasmatic Autoantibodies with Specificity to Proteinase 3

    IV Introduction: Antinuclear Antibodies
    17 Antinuclear Antibodies: General Introduction
    18 Antinucleolar Antibodies
    19 Anti-Chromatin (Nucleosome) Autoantibodies
    20 Centromere Autoantibodies
    21 dsDNA Autoantibodies
    22 Histone Autoantibodies
    23 Ku and Ki Autoantibodies
    24 Neuronal Nuclear Autoantibodies, Type 1 (HU)
    25 Nuclear Envelope Protein Autoantibodies/Antilamin Autoantibodies
    26 Anti-Nucleosome Autoantibodies
    27 Proliferating Cell Nuclear Antigen Autoantibodies
    28 Anti-RA33 Antibodies (Antibodies to the Heterogeneous Nuclear Ribonucleoprotein A2)
    29 Anti-Ribosomal P Antibodies
    30 SS-A (Ro) Autoantibodies
    31 Topoisomerase-I (Scl-70) Autoantibodies
    32 SS-B (La) Autoantibodies
    33 Anti-RNA Polymerase III Antibodies

    V Autoantibodies to Biologic Factors/Structures
    34 GW Bodies, P Bodies and Components of the miRNA Pathway
    35 Golgi Complex and Endosome Antibodies
    36 p53 Autoantibodies
    37 Human Antiganglioside Autoantibodies
    38 Human Anti--Galactosyl Antibodies
    39 Autoantibodies in Therapeutic Preparations of Human Intravenous Immunoglobulin (IVIG)
    40 Cytokine Antibodies
    41 Cytoskeletal Autoantibodies/Anti-Actin Antibodies
    42 Fibrillarin Autoantibodies
    43 Fibronectin Autoantibodies
    44 Interferon-Inducible Protein IFI16 Autoantibodies

    VI Cardiac Autoantibodies
    45 Autoantibodies in Atherosclerosis
    46 Heat Shock Protein Autoantibodies
    47 Myocardial Autoantibodies and their Clinical Significance

    VII Endocrine Autoantibodies
    48 Glutamic Acid Decarboxylase Autoantibodies
    49 Humoral Immunity in Type 1 Diabetes Mellitus
    50 Antibodies to Adrenal, Gonadal Tissues and Steroidogenic Enzymes
    51 Thyroglobulin, Thyroperoxidase, and Thyrotropin-Receptor Autoantibodies

    VIII GI And Liver Autoantibodies
    52 Anti-Intestinal Goblet Cell Antibodies
    53 Tumor-Associated Autoantibodies
    54 Cryoglobulins and Cryoglobulins Secondary to Hepatitis C Virus Infection
    55 Anti-Tissue Transglutaminase and Anti-Endomyisial Antibodies
    56 Anti-Gliadin Antibodies
    57 Reticulin Autoantibodies
    58 Liver Cytosol Antigen Type 1 Autoantibodies, Liver Kidney Microsomal Autoantibodies, and Liver Microsomal Autoantibodies
    59 Antimitochondrial Antibodies
    60 Parietal Cell and Intrinsic Factor Autoantibodies
    61 Smooth Muscle Antibodies

    IX Hematologic Autoantibodies
    62 Coagulation Factor Autoantibodies
    63 Autoantibodies in Heparin-Induced Thrombocytopenia
    64 Platelet Autoantibodies
    65 Red Cell Autoantibodies
    66 Lymphocytotoxic Autoantibodies

    X Kidney Autoantibodies
    67 Anti-ATP Synthase β-Chain Autoantibodies
    68 Glomerular Basement Membrane Autoantibodies
    69 Nephritic Factor Autoantibodies

    XI Neurological System Autoantibodies
    70 Acetylcholine Receptor and Muscle Specific Kinase Autoantibodies
    71 Myositis Autoantibodies: Aminoacyl-tRNA Synthetase, Signal Recognition Particle, Mi-2, and PM-Scl Autoantibodies
    72 Anti-MOG Antibodies
    73 Antibodies to Hsp 70 in Inner Ear Disease
    74 Autoantibodies in the Lambert–Eaton Myasthenic Syndrome (LEMS) and Amyotrophic Lateral Sclerosis (ALS)
    75 Ganglioside Autoantibodies
    76 Myelin Associated Antibodies: Myelin-Associated Glycoprotein Autoantibodies, Myelin Basic Protein Autoantibodies and Myelin Proteolipid Autoantibodies in Neurologic Diseases
    77 Paraneoplastic Neurological Antibodies: Nuclear
    78 Paraneoplastic Neurological Antibodies: Purkinje Cell Cytoplasm
    79 Paraneoplastic Neurological Antibodies: Additional Reactivities
    80 Retinal Autoantibodies
    81 Autoantibodies in Epilepsy

    XII Rheumatic Disease Autoantibodies
    82 Anti-Fodrin Antibodies
    83 Antibodies to Laminin
    84 Autoantibodies Against Muscarinic Acetylcholine Receptor in Patients with Sjögren’s Syndrome
    85 β2-Glycoprotein I Autoantibodies
    86 C1 Inhibitor Autoantibodies
    87 Autoantibodies to C1q
    88 Anti-Collagen Antibodies
    89 Anti-Cyclic Citrullinated Peptide Antibody
    90 Anti-Endothelial Cell Autoantibodies
    91 Lupus Anticoagulant Testing
    92 Anticardiolipin Antibodies
    93 Phospholipid Autoantibodies (Non-Anticardiolipin)–Anti-Prothrombin Antibodies
    94 Rheumatoid Factors

    XIII Skin Disease Autoantibodies
    95 Autoantibodies to Mucocutaneous Antigens

    XIV Unique Clinical Situations
    96 Autoimmunity and the Newer Biopharmaceuticals
    97 Autoantibodies Against Tumor Suppressor Proteins
    98 Detection of Autoantibodies Using Protein Arrays
    99 Autoantibodies and Pregnancy Loss

    XV Future Directions
    100 Anti-Glycan Antibodies
    101 Future Trends

Product details

  • No. of pages: 872
  • Language: English
  • Copyright: © Elsevier Science 2006
  • Published: November 27, 2006
  • Imprint: Elsevier Science
  • eBook ISBN: 9780080467238

About the Editors

Yehuda Shoenfeld

Yehuda Shoenfeld
Professor Yehuda Shoenfeld is the President of the Center for Autoimmune Diseases (present), incumbent of the Laura Schwarz-Kipp Chair for Research of Autoimmune Diseases in Tel Aviv University (since 2002–Present), Emeritus Professor of the Sackler School of Medicine in Tel Aviv University and teaches medical studies and MSc and PhD students (since 1985). Prof. Shoenfeld has edited a series of textbooks entailing "The Mosaic of Autoimmunity," "Autoantibodies," "Infection and Autoimmunity," and "Diagnostic Criteria of Autoimmune Diseases" (Elsevier Pub.). He has served on 36 editorial boards and is the organizer of more than 25 international congresses on autoimmunity. He is the author of > 2000 peer-reviewed papers reported in the field of autoimmunity and internal medicine. More than 65,000 citations.

Affiliations and Expertise

President of the Center for Autoimmune diseases (Present). Incumbent of the Laura Schwarz-Kipp Chair for Research of Autoimmune Diseases in Tel-Aviv University (since 2002 – Present)

Pier Luigi Meroni

Pier Luigi Meroni

Affiliations and Expertise

Department of Clinical Sciences & Community Health, University of Milan, Italy

M. Gershwin

M. Gershwin

Affiliations and Expertise

Division of Rheumatology, Allergy & Clinical Immunology, University of California at Davis School of Medicine, Davis, CA

M.E. Gershwin

M.E. Gershwin

Affiliations and Expertise

University of California, Clinical Division of Rheumatology, School of Medicine, Davis, CA, USA

Y. Shoenfeld

Y. Shoenfeld

Prof. Yehuda Shoenfeld is the founder and head of the Zabludowicz Center for Autoimmune Diseases, at the Sheba Medical Center which is affiliated to the Sackler Faculty of Medicine in Tel-Aviv University, in Israel. Dr. Shoenfeld is the Incumbent of the Laura Schwarz-Kipp Chair for Research of Autoimmune Diseases at the Tel-Aviv University.

His clinical and scientific works focus on autoimmune and rheumatic diseases, and he has published more than 1750 papers in journals such as New Eng J Med, Nature, Lancet, Proc Nat Acad Scie, J Clin Invest, J Immunol, Blood, FASEB, J Exp Med, Circulation, Cancer and others. His articles have had over 35,000 citations. He has written more than three hundred and fifty chapters in books, and has authored and edited 25 books, some of which became cornerstones in science and clinical practice, such as "The Mosaic of Autoimmunity", "Infections and Autoimmunity" and the textbook "Autoantibodies" and "Diagnostic criteria of autoimmune diseases", all of which were published by Elsevier and sold by the thousands.

He is on the editorial board of 43 journals in the field of rheumatology and autoimmunity and is the founder and the editor of the IMAJ (Israel Medical Association Journal) the representative journal of science and medicine in the English language in Israel, and also is the founder and Editor of the "Autoimmunity Reviews" (Elsevier) (Impact factor 7.9) and Co-Editor of "Journal of Autoimmunity" (Impact factor 8.1). He has organized over 20 international congresses in autoimmunity.

Prof. Shoenfeld received the EULAR prize in 2005, in Vienna, Austria: "The infectious etiology of anti-phospholipid syndrome". He has received a gold medal from the Slovak Society of Physicians for his contribution to Israel – Slovakia collaboration (March 2006), and is honorary member of the Hungarian Association of Rheumatology. In UC Davis, USA, Dr. Shoenfeld received the Nelson's Prize for Humanity and Science for 2008. In 2009 he was honored as Doctoris Honoris Causa, from Debrecen University (Hungary), and from 2009 he is honorary member of the Slovenian National Academy of Sciences. He has recently been awarded a Life Contribution Prize in Internal Medicine in Israel, 2012 as well as the ACR Master Award in 2013.

Prof. Shoenfeld has educated a long list of students (>25) being heads of departments and institutes.

Affiliations and Expertise

Zabludowicz Center for Autoimmune Diseases,Sheba Medical Center, Affiliate of Tel-Aviv University, Israel

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