1. Lipid Peroxidation and its Inhibition (E. Niki). Introduction. Lipids in Biomembranes. Peroxidations of Lipids in the Membranes. Inhibition of Lipid Peroxidation. Epilogue. 2. Electron Spin Resonance and Spin Trapping (P.J. Thornalley). Electron Spin Resonance of Free Radical Intermediates in Biological Oxidations. Electron Spin Resonance: Theoretical Principles. Practical Aspects of Electron Spin Resonance of Biological Systems. The ESR Technique of Spin Trapping. Free Radical Intermediates in Biological Oxidations: Classification of Biological Oxidation Mechanisms. Electron Spin Resonance Studies of Free Radicals in Biological Oxidations. Conclusions. 3. Transition Metal Ions and Antioxidant Proteins in Extracellular Fluids (J.M. Gutteridge, B. Halliwell). Oxygen Toxicity. Biological Antioxidants. Protein Antioxidants of Extracellular Fluids. Summary. 4. Sensitization and Protection of Oxidative Damage Caused by High Energy Radiation (P. Wardman). Introduction. Quantitation of Radiation Damage. Targets in Radiobiology: The Focus of Oxidative Stress. The Oxygen Effect in Radiobiology. Oxygen-Mimetic Compounds. Antioxidants as Radiation Protectors. Clinical Exploitation of Radiation Sensitization and Protection. The Oxygen Paradox: Is it a Sensitizer or a Protector? Conclusions. 5. Interactions of Melanin with Oxygen (and Related Species) (T. Sarna, H.M. Swartz). Summary. Introduction. Redox Properties of Melanin Relevant to its Interactions with Oxygen. Oxidation of Monomeric Precursors of Melanin. Interaction of Melanin with Ground State Molecular Oxygen. The Ability of Melanin to Quench and Induce Reactive Species Derived from Oxygen. Oxygen-Dependent Photoreactions of Melanin. Degradative Oxidation of Melanin in the Dark. Appendix. 6. Oxidation of Tetrahydrofolates and Tetrahydrobiopterin by Molecular Oxygen (J.A. Blair, G. Farrar). Introduction. Tetrahydrofo
Volume III addresses our present understanding of how oxidation is involved both positively and negatively in life processes. This is a more recent and rapidly developing aspect of oxidation chemistry and many of the concepts still have to be proved by rigorous scientific investigation. Nevertheless, the mechanistic principles developed as a result of studies in vitro over the years now provide the basis for understanding the complex oxidation chemistry of life processes and its control by biological antioxidants.
- © Elsevier Science 1993
- 10th May 1993
- Elsevier Science
- eBook ISBN: