This volume’s primary goal is to provide a comprehensive understanding of recent developments and advancements in the study of ataxic disorders. Beginning with an examination of the cerebellar region, and then progressing to a fresh perspective on the clinical aspects of the various forms of ataxia, this handbook gives clinicians a state-of-the-art reference for the management of the many etiologies and neurological manifestations of ataxic disorders.

Clinicians will gain a broader understanding of generative ataxias and the genetic disorders associated with them. In addition, new neurophysiological and imaging techniques are discussed, along with an in-depth examination of the treatment and management protocols of ataxic diseases.

Key Features

* A volume in the Handbook of Clinical Neurology series, which has an unparalleled reputation as the world's most comprehensive source of information in neurology.
* International list of contributors including the leading workers in the field.
* Describes the advances which have occurred in clinical neurology and the neurosciences, their impact on the understanding of neurological disorders and on patient care.


Neuroscience research workers

Table of Contents



List of contributors

Chapter 1: The cerebellum – structure and connections

Chapter 2: Physiology of clinical dysfunction of the cerebellum

Chapter 3: Oculomotor aspects of the hereditary cerebellar ataxias

Chapter 4: Magnetic resonance and nuclear medicine imaging in ataxias

Chapter 5: Neuropathology of degenerative ataxias

Chapter 6: Approach to ataxic diseases

Chapter 7: Acquired ataxias, infectious and para-infectious

Chapter 8: Ataxia in patients with brain infarcts and hemorrhages

Chapter 9: Ataxia resulting from posterior fossa tumors of childhood and other mass lesions

Chapter 10: Nutritional cerebellar degeneration, with comments on its relationship to Wernicke disease and alcoholism

Chapter 11: Immune-mediated acquired ataxias

Chapter 12: Toxic agents causing cerebellar ataxias

Chapter 13: Paraneoplastic cerebellar degeneration

Chapter 14: Epidemiology and population genetics of degenerative ataxias

Chapter 15: Sporadic adult-onset ataxia of unknown etiology

Chapter 16: Overview of autosomal recessive ataxias

Chapter 17: Friedreich ataxia

Chapter 18: Ataxia with vitamin E deficiency and abetalipoproteinemia

Chapter 19: Ataxia–telangiectasia

Chapter 20: Autosomal recessive cerebellar ataxias with oculomotor apraxia

Chapter 21: Other autosomal recessive and childhood ataxias

Chapter 22: Ataxia in mitochondrial disorders

Chapter 23: Fragile X-associated tremor/ataxia syndrome

Chapter 24: Overview of autosomal dominant ataxias

Chapter 25: Spinocerebellar ataxia type 1

Chapter 26: Spinocerebellar ataxia type 2

Chapter 27: Machado–Joseph disease/spinocerebellar ataxia type 3

Chapter 28: Spinocerebellar ataxia type 5

Chapter 29: Spinocerebellar ataxia type 6

Chapter 30: Spinocerebellar ataxia


No. of pages:
© 2012
Print ISBN:
Electronic ISBN: