Asymmetric Synthesis V4

Asymmetric Synthesis V4

1st Edition - October 11, 1984

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  • Editor: James Morrison
  • eBook ISBN: 9780323152549

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Asymmetric Synthesis, Volume 4: The Chiral Carbon Pool and Chiral Sulfur, Nitrogen, Phosphorus, and Silicon Centers describes the practical methods of obtaining chiral fragments. Divided into five chapters, this book specifically examines initial chiral transmission and extension. The opening chapter describes the so-called chiral carbon pool, the readily available chiral carbon fragments used as building blocks in synthesis. This chapter also provides a list of 375 chiral building blocks, along with their commercial sources, approximate prices, and methods of synthesis. Schemes involving almost 1,300 structures and the use of chiral building blocks to prepare alkaloids, arachidonic acid metabolites, compounds with chemotherapeutic and pharmacological activity, insect pheromones, sugars, vitamins, terpenoids, and miscellaneous compounds are also included in this text. The remaining chapters provide a similar overview of the chemistry of compounds chiral at sulfur, phosphorus, nitrogen, and silicon. Synthetic chemists and researchers, especially those engaged in pharmaceutical research and specialty chemicals production, will find this book invaluable.

Table of Contents

  • Contributors


    1. Readily Available Chiral Carbon Fragments and Their Use in Synthesis

    I. The Method

    II. The Chiral Building Blocks

    III. Approaches to Synthetic Targets Using Chiral Carbon Building Blocks


    2. Optical Activation and Utilization of Compounds Containing Chiral Sulfur Centers

    I. Introduction

    II. The Optical Activation of Chiral Organosulfur Compounds

    III. Applications of Optically Active Organosulfur Reagents in Asymmetric Synthesis


    3. Preparation of the Enantiomers of Compounds Containing Chiral Phosphorus Centers

    I. Introduction

    II. Chiral Tertiary Phosphines and Related Substances

    III. Four-Coordinate Phosphorus Thioacids and Related Compounds

    IV. Conclusions


    4. Synthesis and Utilization of Compounds with Chiral Nitrogen Centers

    I. Introduction

    II. Chiral Trivalent Nitrogen

    III. Chiral Tetravalent Nitrogen


    5. Synthesis and Utilization of Compounds with Chiral Silicon Centers

    I. Introduction

    II. Mechanism of Reactions at Silicon

    III. Preparation of Optically Active Organosilanes

    IV. Utilization of Optically Active Organosilanes in Synthesis

    V. Concluding Remarks



Product details

  • No. of pages: 392
  • Language: English
  • Copyright: © Academic Press 1984
  • Published: October 11, 1984
  • Imprint: Academic Press
  • eBook ISBN: 9780323152549

About the Editor

James Morrison

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