Asymmetric Synthesis V2 - 1st Edition - ISBN: 9780125077026, 9780323157360

Asymmetric Synthesis V2

1st Edition

Editors: James Morrison
eBook ISBN: 9780323157360
Imprint: Academic Press
Published Date: 1st December 1983
Page Count: 292
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Description

Asymmetrie Synthesis, Volume 2: Stereodifferentiating Addition Reactions, Part A is concerned with asymmetric addition reactions.

This volume contains chapters that cover B-H additions across carbon-carbon and carbon-oxygen double bonds; carbonyl reductions using chiral modifications of lithium aluminum hydride and chiral dihydropyridines; additions of achiral and chiral nucleophiles to chiral and achiral aldehydes and ketones; organometal additions to chiral vinylic sulfoxides; and description of imine and enamine alkylations.

Chemists will find the book interesting.

Table of Contents


Contributors


Preface


1. Asymmetric Hydroboration


I. Introduction


II. Diisopinocampheylborane


III. Dilongifolylborane


IV. Limonylborane


V. Monoisopinocampheylborane


VI. Conclusion


References


2. Reductions with Chiral Boron Reagents


I. Introduction


II. Chirally Modified Boranes


III. Chirally Modified Borohydrides


References


3. Reductions with Chiral Modifications of Lithium Aluminum Hydride


I. Introduction


II. Alcohol-Modified Lithium Aluminum Hydride


III. Amine-Modified Lithium Aluminum Hydride


IV. Amino Alcohol-Modified Lithium Aluminum Hydride


V. Aminodiol-Modified Lithium Aluminum Hydride


VI. Conclusions


References


4. Reductions with Chiral Dihydropyridine Reagents


I. Introduction


II. Summary of the Mechanistic Studies of NADH Model Reactions


III. Asymmetric Reductions with Chiral NADH Model Compounds


IV. Factors Affecting Product Stereochemistry in Asymmetric Reductions with Chiral NADH Model Compounds


V. Approach to Chiral NADH Models of Higher Stereoselectivity


VI. Simulation of Enzyme Active Site Composed of Peptide Chain


VII. Concluding Remarks


References


5. Application of Cram's Rule: Addition of Achiral Nucleophiles to Chiral Substrates


I. Introduction


II. Variation of Reaction Conditions


III. Application of Cram's Rule to Asymmetric Synthesis


IV. Remote Stereochemical Control


References


6. Addition of Chiral Nucleophiles to Aldehydes and Ketones


I. Introduction


II. Organometallic Reagents Used in a Chiral Environment


III. A

Details

No. of pages:
292
Language:
English
Copyright:
© Academic Press 1983
Published:
Imprint:
Academic Press
eBook ISBN:
9780323157360

About the Editor

James Morrison

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