Astrocytes Pt 2: Biochemistry, Physiology, and Pharmacology of Astrocytes

Astrocytes Pt 2: Biochemistry, Physiology, and Pharmacology of Astrocytes

1st Edition - January 5, 1987

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  • Editor: Sergey Fedorff
  • eBook ISBN: 9780323150491

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Astrocytes: Biochemistry, Physiology, and Pharmacology of Astrocytes, Volume 2 focuses on the physiological and pharmacological aspects of astrocytes. This volume gives specific attention to intracellular metabolic activity; membrane components and functions; responses to neurotransmitters and other intrinsic factors; and neuronal-glial interactions. Studies in this text establishe the astrocyte as an essential neuronal partner in the neuronal-glial interrelationship throughout the life-span of the neuron and also further explain the potential roles of astrocytes in brain function. Cell physiologists, neurophysiologists, neuropharmacologists, pediatric neurologists, and gerontologists will find the book interesting.

Table of Contents

  • Foreword


    Electrophysiological Properties of Astrocytes

    I. Introduction

    II. Biophysical Properties

    III. Neuropharmacological Responses

    IV. Electrogenesis of Slow Extracellular Potentials

    V. Function of Astrocytes in Regulating the Brain Microenvironment

    VI. Conclusions


    Ionic Channels in Glial Cells

    I. General Introduction

    II. Na + Channels

    III. Other Channels

    IV. Concluding Remarks



    Astroglia Cells in Culture: Receptors and Cyclic Nucleotides

    I. Introduction

    II. Characterization of Cell Types

    III. Regulation of Cyclic AMP Levels

    IV. Regulation of Cyclic GMP Levels

    V. Conclusion


    Catecholamine and Serotonin Uptake in Astrocytes

    I. Introduction

    II. Uptake Systems for Neurotransmitter Monoamines

    III. Localization of Catecholamine and Serotonin Uptake in Brain

    IV. Uptake into Astrocytes in Vitro

    V. Conclusions


    Amino Acid Uptake

    I. Introduction

    II. Autoradiographic Localization of the Uptake of Amino Acid Transmitters by Astrocytes and Satellite Glial Cells

    III. Autoradiographic Localization of the Uptake of Amino Acid Transmitters by Other Types of Nonneuronal Cells

    IV. Kinetic Characterization of Transport Processes for Amino Acids in Astrocytes

    V. Concluding Remarks


    The Supply of Choline to Glial Cells

    I. Introduction

    II. The Passage of Choline across the Blood-Brain Barrier

    III. Uptake of Choline into Glial Cells

    IV. Production of Choline

    V. De Novo Synthesis of Choline

    VI. Conclusions


    Role of Astrocytes in Compartmentation of Amino Acid and Energy Metabolism

    I. Introduction

    II. Metabolic Compartmentation in Brain Tissue

    III. Transport of Glutamate and Related Amino Acids

    IV. Activities of Enzymes Involved in Interconversions between Glutamate and Related Amino Acids

    V. Metabolic Fluxes of Glutamate and Related Amino Acids or Other Substrates

    VI. Ammonia Turnover

    VII. Concluding Remarks


    Enzyme Induction and Regulation of Protein Synthesis

    I. Regulation of Cellular and Extracellular Astroglial Proteins

    II. Glutamine Synthetase

    III. Glial Fibrillary Acidic Protein

    IV. Carbonic Anhydrase

    V. S-100 Protein

    VI. Future Directions


    Distribution and Regulation of Hydrogen Ions in Astrocytes

    I. Introduction

    II. Measurement of Intracellular pH

    III. Glial Cell Cultures

    IV. Intracellular pH of Cultured Glial Cells

    V. Summary


    Astrocytic Lipids and their Metabolism

    I. Lipid Composition

    II. Lipid Metabolism


    Nutritional Requirements of Cultured Astroglial Cells

    I. Introduction

    II. Growth of Astroglial Cells in Serum-Containing Media

    III. Growth of Astroglial Cells in Serum-Free Chemically Defined Media

    IV. Growth Factors Affecting Astroglial Cells in Culture

    V. Conclusions


    Neuronal-Glial Interactions

    I. Effects of Glia on Neurons

    II. Effects of Neurons on Glia

    III. Summary and Conclusions


    Astroglial Cell Contributions to Neuronal Survival and Neuritic Growth

    I. Introduction and Hypothesis

    II. In Vitro Evidence of Neuronal Regulation by Astroglial (and Other) Molecules

    III. In Vivo Studies Implicating Neuronal Regulation by Astroglial Cells

    IV. In Vivo-in Vitro Combined Strategies

    V. Conclusions and Projections


    Changes in Astrocytes with Aging

    I. Introduction

    II. Astrocyte Population

    III. Biochemical Changes

    IV. Microenvironment

    V. Synapse Function

    VI. Pathological Reactions in Astrocytes



Product details

  • No. of pages: 434
  • Language: English
  • Copyright: © Academic Press 1987
  • Published: January 5, 1987
  • Imprint: Academic Press
  • eBook ISBN: 9780323150491

About the Editor

Sergey Fedorff

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