Asthma

Asthma

Physiology, Immunopharmacology, and Treatment

1st Edition - January 28, 1974

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  • Editors: K. Frank Austen, Lawrence M. Lichtenstein
  • eBook ISBN: 9781483216263

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Description

Asthma: Physiology, Immunopharmacology, and Treatment is a collection of essays that discusses the clinical signs and symptoms of allergic bronchial asthma and the effects of a number of intricate sequences of biochemical reactions initiated by the combination of antigen and antibody. It presents such topic as the pathobiologic mechanisms of asthma. The book discusses the physiologic changes in the acute asthmatic attack. It focuses on the autonomic regulation of airway smooth muscle and the nervous regulation of respiration. Another topic of interest is the genetic aspects of asthma. The section that follows is a review of the biochemical, pharmacological, and immunological factors in the release of chemical mediators from human lung. The book also presents the characteristics of pharmacologic receptor systems and the role of parasympathetic nervous system in asthma. The text will provide valuable insights for physicians, scientists, students, and researchers in the field of human anatomy.

Table of Contents


  • List of Contributors

    Participants

    Preface

    Chapter 1 Bronchial Asthma: Pathophysiology

    Original Observations

    Discussion

    References

    Discussion

    Chapter 2 Physiologic Changes in the Acute Asthmatic Attack

    Text

    Summary

    References

    Discussion

    Chapter 3 Neurophysiologic Aspects of Asthma

    Autonomic Regulation of Airway Smooth Muscle

    Nervous Regulation of Respiration

    References

    Discussion

    Chapter 4 The Genetic Basis of Asthma

    History

    Twin Studies

    Recent Family Studies

    Hypothetical Genetic Mechanisms

    Conclusion

    References

    Discussion

    Chapter 5 Role of IgE and IgG Antibodies in Reaginic Hypersensitivity in the Respiratory Tract

    Introduction

    Does IgG Antibody Induce or Block Reaginic Allergy?

    Does IgG Antibody Regulate IgE Antibody Production?

    References

    Discussion

    Chapter 6 A Human Heat-Stable Anaphylactic or Anaphylactoid Antibody Which May Participate in Pulmonary Disorders

    Examination of the Properties of the Short-Term Sensitizing IgG Antibody (IgG S-T S)

    References

    Discussion

    Chapter 7 The Control of IgE-Mediated Histamine Release: Implications for the Study of Asthma

    Text

    References

    Discussion

    Chapter 8 A Review of Immunological, Biochemical, and Pharmacological Factors in the Release of Chemical Mediators from Human Lung

    Role of IgE in Mediator Release

    Characteristics of the Chemical Mediators

    Biochemical Prerequisites for Mediator Release

    Pharmacologic Control of Mediator Release

    Concluding Comments

    References

    Discussion

    Chapter 9 Cyclic Nucleotides and Smooth Muscle Function

    Cyclic AMP and Smooth Muscle

    Cyclic GMP

    Alteration of Cyclic Nucleotide Levels in Smooth Muscle

    Does Cyclic GMP Mediate the Effects of Smooth Muscle Stimulants?

    Conclusions

    References

    Discussion

    Chapter 10 Drug Receptors in Smooth Muscle

    Introduction

    Basic Concepts of Pharmacologic Receptors

    Alterations in Pharmacologic Receptor Activity

    Drug Receptors in Tracheobronchial Tree

    Clinical Importance of Pharmacologic Receptors in Asthma

    Characteristics of Pharmacologic Receptor Systems

    Conclusion

    References

    Discussion

    Chapter 11 Cholinergic Pharmacology in Asthma

    Background

    Role of the Parasympathetic Nervous System in Asthma

    Summary

    References

    Discussion

    Chapter 12 Adrenergic Responsiveness in Asthma

    Introduction

    Catecholamine Responsiveness in Vivo in Individuals with Asthma

    In Vitro Studies of Adrenergic Responsiveness

    Unresolved Questions

    Possible Applications

    Summary

    References

    Discussion

    Chapter 13 A Review of Immunotherapy in Asthma

    Text

    References

    Discussion

    Chapter 14 Effects of Corticosteroids on the Stability and Fusion of Biomembranes

    Introduction

    Cortisone and Lysosomal Membranes

    Cortisone and Artificial Membranes

    Cortisone and Membrane Fusion

    Cortisone in the Cell Undergoing Reverse Endocytosis

    Summary

    References

    Discussion

    Chapter 15 Phosphodiesterase Inhibitors and Analogs of Cyclic AMP as Potential Agents for the Treatment of Asthma

    Text

    Summary and Discussion

    References

    Discussion

    Chapter 16 Selectively Acting β-Adrenoceptor Stimulants in Asthma

    General Introduction

    Comparison of the Biological Properties of Selected β-Adrenoreceptor Stimulants

    Pharmacology

    Clinical Results

    The Clinical Significance of Selective β2-Adrenoreceptor Stimulants

    Physicochemical Basis of Selective β-Adrenoreceptor Stimulation

    References

    Discussion

    Chapter 17 Role of Prostaglandins in the Pathogenesis and Treatment of Asthma

    Introduction

    Actions of the Ε-Series Prostaglandins on the Bronchus

    Actions of PGF2α on the Bronchus

    Prostaglandins, Inflammation, and Allergy

    Prostaglandin Antagonists

    Discussion

    Conclusions

    References

    Discussion

    Chapter 18 Disodium Cromoglycate in Clinical and Experimental Asthma

    Clinical Effects of Disodium Cromoglycate

    Long-Term (1 Year) Trials of Disodium Cromoglycate in Asthma

    Types of Asthmatic Reaction to Provocation Tests and Effects of Disodium Cromoglycate

    Comparison of Effects of Disodium Cromoglycate and Corticosteroids in Asthma

    Effects of Disodium Cromoglycate on Asthmatic Reactions in Subjects Sensitive to Chemical Inorganic and Organic Dusts, Fumes, and Gases

    Effect of Disodium Cromoglycate on Asthma Due to Ingested Allergens

    Effect of Disodium Cromoglycate in Allergic Rhinitis

    Conclusions

    References

    Discussion

    Chapter 19 General Discussion

    Index of Participants

    Subject Index

Product details

  • No. of pages: 344
  • Language: English
  • Copyright: © Academic Press 1974
  • Published: January 28, 1974
  • Imprint: Academic Press
  • eBook ISBN: 9781483216263

About the Editors

K. Frank Austen

Affiliations and Expertise

Scripps Clinic and Research Foundation la Jolla, California

Lawrence M. Lichtenstein

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