Asthma in the 21st Century

Asthma in the 21st Century

New Research Advances

1st Edition - September 8, 2022

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  • Editor: Rachel Nadif
  • eBook ISBN: 9780323854207
  • Paperback ISBN: 9780323854191

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Asthma in the 21st Century: New Research Advances provides an overview on asthma, with discussions on its heterogeneity, risk factors and their interrelations, and e-health in an aging world based on current research knowledge. The book covers heterogeneity of the disease beyond severe asthma, new risk factors, new diagnoses with climate change, a focus on chemical exposures at home, e-health and links with aging, and notable advances in key areas such as diet and microbiota, the genetics of asthma, and the asthma versus COPD debate. Worldwide, the total number of asthma sufferers is estimated to be ~270 million with an additional 100 million expected to develop asthma by 2025, and asthma is the most common chronic disease among children. There are a number of clinical books available on asthma, but none with much discussion on current scientific findings and new disease understanding. Yet, the concept of asthma has evolved quickly in the past 5–10 years, with many clinicians struggling to keep up with new scientific findings.

Key Features

  • Offers an overall view of asthma and addresses notable advances in key areas such as diet and the microbiota, the genetics of asthma, and asthma-COPD overlap syndrome
  • Covers hot topics such as heterogeneity of asthma beyond severe asthma, new risk factors, more common complications with climate change, a focus on chemical exposures at home, e-health, and links with frailty in an aging world
  • Provides a deep understanding of a multifactorial, complex, and heterogeneous chronic inflammatory disease known as asthma


Scientific researchers, such as PhDs, that do asthma research; and practicing clinicians that care for asthma patients, including pediatricians, primary care physicians, pulmonologists, allergists in addition to fellows, trainees and physician extenders (i.e. nurse practitioners and physician assistants) in these fields. Professors/ academics may find the book useful for teaching. Trainees or students in pulmonology, allergy and physiology Other healthcare stake holders, such as insurance companies, NIH, Pharma industry, providing both basic disease understanding in addition to more in-depth, complex passages for the trained researcher or care provider

Table of Contents

  • Cover Image
  • Title Page
  • Copyright
  • Table of Contents
  • Contributors
  • Foreword
  • Acknowledgments
  • Chapter 1 Asthma: From one disease to endotypes
  • 1.1 Introduction
  • 1.2 History of “asthma”
  • 1.3 Clinical and epidemiological aspects of asthma
  • 1.4 Asthma phenotypes
  • 1.5 Asthma endotypes
  • 1.6 Conclusion
  • References
  • Chapter 2 Eosinophilic and noneosinophilic asthma: Beyond severe asthma
  • 2.1 Introduction
  • 2.2 Eosinophilic asthma
  • 2.2 Noneosinophilic asthma
  • 2.3 Implications for treatment of asthma
  • 2.4 Conclusion
  • References
  • Chapter 3 Airway microbiome and asthma
  • 3.1 Introduction
  • 3.2 Sampling and characterization of airway microbiome
  • 3.3 Airway microbiota and asthma in adults
  • 3.4 Airway microbiota, wheezing and asthma in children
  • 3.5 Early life environment and airway microbiota
  • 3.6 Gut microbiota, airway microbiota and the gut–lung axis in asthma
  • 3.7 Conclusion and future directions
  • References
  • Chapter 4 Gender differences and sex-related hormonal factors in asthma
  • 4.1 Introduction
  • 4.2 Gender differences in asthma, findings from epidemiologic studies
  • 4.3 Hormonal factors: Events associated with changes in sex hormones among women
  • 4.4 Hormones and respiratory health
  • 4.5 Gender specific determinants of asthma, beyond sex hormones
  • 4.6 Conclusion
  • References
  • Chapter 5 Diet and asthma
  • 5.1 Introduction
  • 5.2 Assessment of diet in epidemiological studies
  • 5.3 Windows of exposure and expression, and measurement error
  • 5.4 Diet and asthma: State of the art
  • 5.5 Complex interrelations between diet, obesity, and physical activity in asthma prevention and management
  • 5.6 Conclusion and future directions
  • References
  • Chapter 6 Indoor air and respiratory health: Volatile organic compounds and cleaning products
  • 6.1 Introduction
  • 6.2 Exposure assessment of indoor chemicals: VOCs, SVOCs, and cleaning products
  • 6.3 Respiratory health effects of residential exposure to VOCs, SVOCs, and cleaning products: Results from epidemiological studies
  • 6.4 Conclusions on respiratory health effects of cleaning products
  • 6.5 Conclusion and future directions
  • References
  • Chapter 7 Outdoor air pollution and asthma in a changing climate
  • 7.1 General introduction
  • 7.2 Air pollution and asthma
  • 7.3 Asthma and air pollution in the context of climate change
  • 7.4 General conclusion
  • References
  • Chapter 8 Genetic and epigenetic links to asthma
  • 8.1 Introduction
  • 8.2 Asthma gene discovery through genome-wide association studies
  • 8.3 The role of rare and loss-of-function variants in asthma
  • 8.4 Epigenomic studies of asthma
  • 8.5 Conclusions and future directions
  • References
  • Chapter 9 Asthma and COPD: distinct diseases or components of a continuum?
  • 9.1 Introduction
  • 9.2 Asthma, COPD, overlap: definitions and basic epidemiology
  • 9.3 Natural history of and risk factors for obstructive airways diseases, from childhood to advanced age
  • 9.4 Shared and distinct underlying mechanisms
  • 9.5 Clinical presentations and diagnostic challenges
  • 9.6 Physiological similarities and differences between asthma and COPD
  • 9.7 The role of imaging in the assessment of chronic airways diseases
  • 9.8 Therapeutic implications
  • 9.9 Conclusions
  • References
  • Chapter 10 Asthma in an aging world
  • 10.1 Introduction
  • 10.2 Epidemiology of asthma in the elderly
  • 10.3 Physiological change in the airways due to aging
  • 10.4 Phenotype of asthma in the elderly
  • 10.5 Problems in diagnosing asthma in the elderly
  • 10.6 Treatment of asthma in the elderly
  • 10.7 Conclusion
  • References
  • Chapter 11 Asthma in the digital world
  • 11.1 Introduction
  • 11.2 Regulatory framework for data protection
  • 11.3 Electronic health records
  • 11.4 Registries in severe asthma
  • 11.5 Telehealth in asthma
  • 11.6 mHealth apps
  • 11.7 mHealth sensors
  • 11.8 Platforms
  • 11.9 Serious games
  • 11.10 Impact of digital health on asthma
  • 11.11 Conclusion
  • References
  • Index

Product details

  • No. of pages: 262
  • Language: English
  • Copyright: © Academic Press 2022
  • Published: September 8, 2022
  • Imprint: Academic Press
  • eBook ISBN: 9780323854207
  • Paperback ISBN: 9780323854191

About the Editor

Rachel Nadif

Dr Rachel Nadif is a Senior Researcher at French Institute of Health and Medical Research (inserm) and the Head of the Integrative Respiratory Team in the Centre for Epidemiology and Population Health (Inserm U1018). She has a background in biology and epidemiology, and a strong expertise in respiratory epidemiology. Her research program aims to refine asthma phenotypes by including biological markers, and to better understand the etiology of asthma and rhinitis by studying the associations with environment, genes and their interactions.

Affiliations and Expertise

Head Professor, Integrative Respiratory Team, Paris, France; Senior Investigator, French Institute of Health and Medical Research, Paris, France

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