Assessments, Treatments and Modeling in Aging and Neurological Disease

Assessments, Treatments and Modeling in Aging and Neurological Disease

The Neuroscience of Aging

1st Edition - June 1, 2021

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  • Editors: Colin Martin, Victor Preedy, Rajkumar Rajendram
  • Hardcover ISBN: 9780128180006
  • eBook ISBN: 9780128180013

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Assessments, Treatments and Modeling in Aging and Neurological Disease: The Neuroscience of Aging is a comprehensive reference on the diagnosis and management of neurological aging and associated disorders. The book discusses the mechanisms underlying neurological aging and provides readers with a detailed introduction to the aging of neural connections and complexities in biological circuitries, as well as the interactions between genetics, epigenetics and other micro-environmental processes. It also examines pharmacological and non-pharmacological interventions of age-related conditions that affect the brain, including Alzheimer’s, stroke and multiple sclerosis.

Key Features

  • Provides the most comprehensive coverage of the broad range of topics related to the neuroscience of aging
  • Features sections on diagnosis and biomarkers of neurological aging, Alzheimer’s and stroke
  • Contains an abstract, key facts, a mini dictionary of terms, and summary points in each chapter
  • Focuses on neurological diseases and conditions linked to aging, environmental factors and clinical recommendations
  • Includes more than 500 illustrations and tables


Neuroscientists, geriatricians, neurobiologists, experimental biologists, clinicians, graduate students, and post-doctoral fellows

Table of Contents

  • Part I
    Introductory chapters: Setting the scene for the neuroscience of aging

    1. The concept of productive aging
    Premchand Dommaraju and Shawn Wong

    2. Quality of life in older people
    Timo E. Strandberg

    3. Successful aging and diet
    Ekavi N. Georgousopoulou, Duane D. Mellor and Demosthenes B. Panagiotakos

    4. The impact of positive social relations on the quality of life of older people. An alternative to medicalization from an integral
    Luis Miguel Rondo

    5. The brain in life span: use of phase functional magnetic resonance
    Zikuan Chen, Zeyuan Chen and Bihong T. Chen

    6. Neuronal structure in aging:
    cytoskeleton in health and disease
    Daniele Cartelli

    7. Sporadic Alzheimer’s triad: age, sex, and ApoE
    Xin Zhang, Punam Rawal, Long Wu and Liqin Zhao

    8. The moderating effect of BDNF Val66Met polymorphism on
    inhibitory control in elderly individuals
    Michel Audiffren, Nathalie Andre´, Delphine Fagot, Christian Chicherio and Ce´dric Albinet

    9. Alcohol use disorder pharmacotherapy options for postmenopausal females: age and gender issues and considerations
    Jelena Milic, Janko Zekovic, Dunja Stankic, Ed van Beeck and Janko Samardzic

    10. The aging brain and brain banking
    R.C. Jezewski, G.M. Halliday and C.E. Shepherd

    Part II
    Impairments and diseases

    11. Dementia or no dementia in the elderly. Why?
    Lewis H. Kuller

    12. Neuropsychology, social cognition, and loss of insight in
    frontotemporal dementia
    Fiadhnait O’Keeffe and Derval McCormack

    13. Neuroinflammation and aging
    Joaeo O. Malva, Ricardo Moreira, Beatriz Martins, Joaeo Novo, Frederico C. Pereira, Ramon Raposo, Reinaldo B. Oria´ and Carlos Fontes Ribeiro

    14. Cortical microinfarcts and the aging brain
    Eniko Kovari and Gabriel Gold

    15. Cerebrovascular and neuro>degenerative racial/ethnic health
    Astrid M. Suchy-Dicey

    16. Hearing loss among the elderly
    Gary Jek Chong LEE

    17. Aging auditory cortex: the impact of reduced inhibition on function
    Bjo€rn Herrmann and Blake E. Butler

    18. Aging and vestibular disorders
    Augusto Pietro Casani and Elena Navari

    19. Brain aging in HIV and retrovirals
    Jasmina Boban, Majda M. Thurnher and Dusko Kozic

    20. Methylmercury exposure and its implications for aging
    Andrew N. Shen and M. Christopher Newland

    21. Alcohol and the aging brain: increased alcohol sensitivity potentially magnifying oxidative stress
    Candice E. Van Skike and Douglas B. Matthews

    Part III
    Biomarkers and diagnosis

    22. Brain aging: radiological biomarkers
    Banu Alicioglu and Hakki Muammer Karakas

    23. ADAM10 as a biomarker for Alzheimer’s disease
    Mariana Luciano de Almeida, Izabela Pereira Vatanabe, Patricia Regina Manzine, Rafaela Peron, Carlos Roberto Bueno Ju´nior and Ma´rcia Regina Cominetti

    24. Circulating microRNAs as biomarkers of health in elderly
    Jonas Mengel-From

    25. DHEA as a biomarker of aging in humans and nonhuman primates:
    synthesis, neuroprotection, and cognitive function
    Henryk F. Urbanski

    26. Evaluation of subjective memory abilities in elderly people
    Luigi Trojano, Gabriella Santangelo and Simona Raimo

    27. The functional activities questionnaire: applications to aging
    Ondrej Bezdicek

    28. Autobiographical memory as a diagnostic tool in aging
    Juan C. Mele´ndez and Encarnacio´n Satorres

    29. Assessment tools for subjective memory abilities in elderly people
    Simona Raimo, Gabriella Santangelo and Luigi Trojano

    30. The Knowledge of Memory Aging Questionnaire
    Celinda Reese-Melancon, Katie E. Cherry and Erin E. Harrington

    Part IV
    Management and treatments

    31. Pharmacological use of transient receptor potential (TRP) ion
    channel agonists in neurological disease and aging: effects on swallowing and implications for nutrition
    Noemı´ Tomsen and Pere Clave´

    32. Aripiprazole: features and use in the aged
    Unax Lertxundi, Rafael Herna´ndez and Juan Medrano

    33. Cognition-enhancing drugs and applications to aging
    Jelena Mili

    34. Creatine supplementation in the aging brain
    Marina Yazigi Solis, Eimear Dolan, Guilherme Giannini Artioli and Bruno Gualano

    35. Photobiomodulation as a brain-boosting strategy in aging
    Farzad Salehpour, Marvin H. Berman and Saeed Sadigh-Eteghad

    36. Innovations in deep brain stimulation in aging: a focus on
    Parkinson disease
    Paolo Amami

    37. Exergames: what they are and how they can be used to successful
    Renato Sobral Monteiro-Junior, Ana Carolina de Mello Alves Rodrigues, Laı´s Francielle Francisca Felı´cio, Luiz Felipe da Silva Figueiredo and Tu´lio Brandaeo Xavier-Rocha

    38. Linking cognitive decline and ballroom dance as a therapeutic
    intervention in the elderly
    Jacqueline C. Dominguez, Maria Clarissa O. del Moral, Ma Fe P. de Guzman and Jeshya A. Chio

    39. Training the functionality of daily life. A new neuroscientific paradigm of cognitive training
    Carmen Requena, Paula A´lvarez-Merino and Francisco Javier Belchı´

    40. Integrated medical and psychiatric self-management smartphone
    technologies for older adults with serious mental illness
    Karen L. Fortuna and Cynthia Bianco

    41. Psychosocial interventions for suicide prevention in the elderly:
    advances and future directions
    Theresa Ebo, Hannah Reich, Elizabeth Arslanoglou, Claudia Heidenreich, Jody Monkovic and Dimitris Kiosses

    Part V
    Models and modelling

    42. D-galactose-induced aging and brain mitochondria
    Fereshteh Farajdokht, Saeed Sadigh-Eteghad and Javad Mahmoudi

    43. Drosophila models of neuronal aging
    Vı´ctor Lo´pez del Amo, Andrea Tapia and Ma´ximo Ibo Galindo

    44. The zebrafish (Danio rerio) and its uses for understanding the
    neuroscience of aging: applications and observation
    Dilan Celebi-Birand, Melek Umay Tuz-Sasik, Narin Ilgim Ardic-Avci, Hande Ozge Aydogan, Begun Erbaba, Elif Tugce Karoglu-Eravsar, Hulusi Kafaligonul and Michelle M. Adams

    45. Murine models of tauopathies: a platform to study neurodegenerative diseases associated with aging
    Ghazaleh Eskandari-Sedighi and David Westaway

    46. Modeling nutrition and brain aging in rodents
    Devin Wahl, Rahul Gokarn, Samantha M. Solon-Biet, Victoria C. Cogger, Thomas J. LaRocca, David Raubenheimer, Stephen J. Simpson
    and David G. Le Couteur

    47. Nonhuman primates as models for aging and Alzheimer’s disease
    Melissa K. Edler, Emily L. Munger, Hayley Groetz and Mary Ann Raghanti

    48. Linking aging and animal models to neurodegeneration: the striatum, substantia nigra, and Parkinson’s disease
    Rodrigo Portes Ureshino and Ana Lo´pez Ramı´rez

    49. Behavioral evaluation of aging in experimental animals
    Ana Perez-Villalba and Isabel Farin˜as

    Part VI

    50. Recommended resources on the neuroscience of aging
    Rajkumar Rajendram and Victor R. Preedy

Product details

  • No. of pages: 606
  • Language: English
  • Copyright: © Academic Press 2021
  • Published: June 1, 2021
  • Imprint: Academic Press
  • Hardcover ISBN: 9780128180006
  • eBook ISBN: 9780128180013

About the Editors

Colin Martin

Dr. Martin is a Professor of Mental Health at Buckinghamshire New University. He is a Registered Nurse, Chartered Health Psychologist, and a Chartered Scientist. He has published or has in press well over 250 research papers and book chapters. He is a keen book author and editor having written and/or edited several books all of which reflect his diverse academic and clinical interests that examine in-depth, the interface between mental health and physical health. These outputs include the Handbook of Behavior; Food and Nutrition (2011), Perinatal Mental Health: A Clinical Guide (2012); Nanomedicine and the Nervous System (2012), and the major reference works Comprehensive Guide to Autism (2014), Diet and Nutrition in Dementia and Cognitive Decline (2015), Comprehensive Guide to Post-Traumatic Stress Disorder (2016) and Metabolism and Pathophysiology of Bariatric Surgery: Nutrition, Procedures, Outcomes, and Adverse Effects (2017).

Affiliations and Expertise

Professor of Clinical Psychobiology and Applied Psychoneuroimmunology and Clinical Director: Institute for Health and Wellbeing, University of Suffolk, Ipswich, UK

Victor Preedy

Victor R. Preedy BSc, PhD, DSc, FRSB, FRSPH, FRCPath, FRSC is Emeritus Professor of Nutritional Biochemistry, at King’s College London and Professor of Clinical Biochemistry (Hon) at King’s College Hospital. He was the long-term Director of the Genomics Centre at King’s College London from 2006 to 2020. Professor Preedy has carried out research when attached to Imperial College London, The School of Pharmacy (now part of University College London) and the MRC Centre at Northwick Park Hospital. He has collaborated with research groups in Finland, Japan, Australia, USA and Germany. Prof. Preedy is a leading expert on the science of health and has a long-standing interest in dietary and plant-based components. To his credit, Professor Preedy has published over 750 articles, which includes peer-reviewed manuscripts based on original research, abstracts and symposium presentations, reviews and numerous books and volumes.

Affiliations and Expertise

Emeritus Professor, King’s College London; Professor, King’s College Hospital, London, UK

Rajkumar Rajendram

Dr. Rajendram is a clinician scientist whose focus is on perioperative medicine, anesthesia, and intensive care. He graduated in 2001 with a distinction from Guy’s, King’s, and St. Thomas Medical School in London, and began his postgraduate medical training in general medicine and intensive care in Oxford. Dr. Rajendram returned to Oxford as a consultant in general medicine at the John Radcliffe Hospital, Oxford, before moving to the Royal Free London Hospitals as a consultant in intensive care, anesthesia, and perioperative medicine. He is currently a consultant in internal and perioperative medicine at King Abdulaziz Medical City, Riyadh, Saudi Arabia. As a visiting lecturer in the Division of Diabetes and Nutritional Sciences, King’s College London, he has published over 100 textbook chapters, review articles, peer-reviewed papers, and abstracts.

Affiliations and Expertise

Visiting Lecturer, Division of Diabetes and Nutritional Sciences, King’s College London, UK

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