Assessing Nanoparticle Risks to Human Health - 1st Edition - ISBN: 9781437778632, 9781437778649

Assessing Nanoparticle Risks to Human Health

1st Edition

Editors: Gurumurthy Ramachandran
Authors: Gurumurthy Ramachandran
Hardcover ISBN: 9781437778632
eBook ISBN: 9781437778649
Imprint: William Andrew
Published Date: 14th September 2011
Page Count: 297
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Table of Contents

  • Preface
  • About the Editor
  • About the Contributors
  • Chapter 1. Challenges in Nanoparticle Risk Assessment
    • 1.1. Introduction
    • 1.2. The Nature of the Engineered Nanomaterial Challenge
    • 1.3. The Problem with Definitions
    • 1.4. Principles-Based Problem Formulation for Engineered Nanomaterials
    • 1.5. Applying the Principles to Engineered Nanomaterials
    • 1.6. Looking Forward
  • Chapter 2. Assessing Exposures to Nanomaterials in the Occupational Environment
    • 2.1. Nanotechnology and Nanoparticles
    • 2.2. Exposure Routes
    • 2.3. Measurement of Health-Related Exposure Metrics
    • 2.4. Instrumentation
    • 2.5. Exposure Assessment Strategy
  • Chapter 3. Hazard and Risk Assessment of Workplace Exposure to Engineered Nanoparticles
    • 3.1. Introduction
    • 3.2. Case Study Example: Carbon Nanotubes
    • 3.3. Discussion
    • 3.4. Appendix: Pulmonary Ventilation Rate Calculations
  • Chapter 4. Pulmonary Bioassay Methods for Evaluating Hazards Following Exposures to Nanoscale or Fine Particulate Materials
    • 4.1. Introduction and General Background
    • 4.2. What Is Postulated About the Lung Hazards of Nanoparticle Exposures
    • 4.3. Species Differences in Lung Responses to Inhaled Fine and/or Ultrafine TiO2 Particles
    • 4.4. Pulmonary Bioassay Studies
  • Chapter 5. Using Expert Judgment for Risk Assessment
    • 5.1. Uncertainties in Risk Assessment
    • 5.2. Limitations of Existing Methodologies for Risk Assessment and Precedents for Using Expert Judgment
    • 5.3. Eliciting Expert Judgment – Selection of Experts, Elicitation Protocols and Best Practices
    • 5.4. Arriving at Consensus Risk Estimates
    • 5.5. The Use of Expert Judgment for Nanoparticle Risks
    • 5.6. Conclusions
  • Chapter 6. Risk Assessment Using Control Banding
    • 6.1. Introduction
    • 6.2. Challenges Related to the Traditional Industrial Hygiene Approach
    • 6.3. CB Nanotool
    • 6.4. Evaluation of the CB Nanotool
    • 6.5. Considerations for the Nanotechnology Industry
    • 6.6. Conclusion
  • Chapter 7. Controlling Nanoparticle Exposures
    • 7.1. Introduction
    • 7.2. The Hierarchy of Control
    • 7.3. Criteria for Prioritizing Control Options
    • 7.4. Form of Nanomaterials
    • 7.5. Local Exhaust Ventilation
    • 7.6. Air Pollution Control Devices
    • 7.7. Work Practices
    • 7.8. Personal Protective Equipment
    • 7.9. Summary and Recommendations
  • Chapter 8. Addressing the Risks of Nanomaterials under United States and European Union Regulatory Frameworks for Chemicals*
    • 8.1. Introduction
    • 8.2. US Chemicals Regulation
    • 8.3. European Union Chemicals Regulation
    • 8.4. Comparative Analysis
    • 8.5. Conclusion
  • Index

Description

  • Preface
  • About the Editor
  • About the Contributors
  • Chapter 1. Challenges in Nanoparticle Risk Assessment
    • 1.1. Introduction
    • 1.2. The Nature of the Engineered Nanomaterial Challenge
    • 1.3. The Problem with Definitions
    • 1.4. Principles-Based Problem Formulation for Engineered Nanomaterials
    • 1.5. Applying the Principles to Engineered Nanomaterials
    • 1.6. Looking Forward
  • Chapter 2. Assessing Exposures to Nanomaterials in the Occupational Environment
    • 2.1. Nanotechnology and Nanoparticles
    • 2.2. Exposure Routes
    • 2.3. Measurement of Health-Related Exposure Metrics
    • 2.4. Instrumentation
    • 2.5. Exposure Assessment Strategy
  • Chapter 3. Hazard and Risk Assessment of Workplace Exposure to Engineered Nanoparticles
    • 3.1. Introduction
    • 3.2. Case Study Example: Carbon Nanotubes
    • 3.3. Discussion
    • 3.4. Appendix: Pulmonary Ventilation Rate Calculations
  • Chapter 4. Pulmonary Bioassay Methods for Evaluating Hazards Following Exposures to Nanoscale or Fine Particulate Materials
    • 4.1. Introduction and General Background
    • 4.2. What Is Postulated About the Lung Hazards of Nanoparticle Exposures
    • 4.3. Species Differences in Lung Responses to Inhaled Fine and/or Ultrafine TiO2 Particles
    • 4.4. Pulmonary Bioassay Studies
  • Chapter 5. Using Expert Judgment for Risk Assessment
    • 5.1. Uncertainties in Risk Assessment
    • 5.2. Limitations of Existing Methodologies for Risk Assessment and Precedents for Using Expert Judgment
    • 5.3. Eliciting Expert Judgment – Selection of Experts, Elicitation Protocols and Best Practices
    • 5.4. Arriving at Consensus Risk Estimates
    • 5.5. The Use of Expert Judgment for Nanoparticle Risks
    • 5.6. Conclusions
  • Chapter 6. Risk Assessment Using Control Banding
    • 6.1. Introduction
    • 6.2. Challenges Related to the Traditional Industrial Hygiene Approach
    • 6.3. CB Nanotool
    • 6.4. Evaluation of the CB Nanotool
    • 6.5. Considerations for the Nanotechnology Industry
    • 6.6. Conclusion
  • Chapter 7. Controlling Nanoparticle Exposures
    • 7.1. Introduction
    • 7.2. The Hierarchy of Control
    • 7.3. Criteria for Prioritizing Control Options
    • 7.4. Form of Nanomaterials
    • 7.5. Local Exhaust Ventilation
    • 7.6. Air Pollution Control Devices
    • 7.7. Work Practices
    • 7.8. Personal Protective Equipment
    • 7.9. Summary and Recommendations
  • Chapter 8. Addressing the Risks of Nanomaterials under United States and European Union Regulatory Frameworks for Chemicals*
    • 8.1. Introduction
    • 8.2. US Chemicals Regulation
    • 8.3. European Union Chemicals Regulation
    • 8.4. Comparative Analysis
    • 8.5. Conclusion
  • Index

Details

No. of pages:
297
Language:
English
Copyright:
© William Andrew 2011
Published:
Imprint:
William Andrew
eBook ISBN:
9781437778649
Hardcover ISBN:
9781437778632
Paperback ISBN:
9780128103692

Reviews

"This is a very thought-provoking and knowledgeable book for all those interested in how exposure risks may be assessed and managed, particularly of materials which are so widely used, but the safety of which, so little is known."--BTS Winter 2012, Issue 41, page 32-33


About the Editors

Gurumurthy Ramachandran Editor

Gurumurthy Ramachandran is a Professor in the Division of Environmental Health Sciences, University of Minnesota, USA

Affiliations and Expertise

Division of Environmental Health Sciences, University of Minnesota, USA

About the Authors

Gurumurthy Ramachandran Author

Gurumurthy Ramachandran is a Professor in the Division of Environmental Health Sciences, University of Minnesota, USA

Affiliations and Expertise

Division of Environmental Health Sciences, University of Minnesota, USA