Aspirin and the Salicylates

Aspirin and the Salicylates

1st Edition - March 19, 1984

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  • Author: K. D. Rainsford
  • eBook ISBN: 9781483191997

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Description

Aspirin and the Salicylates focuses principally on aspirin. Topics ranging from analytical chemistry and pediatric medicine, taxonomy and cartels, enzymology and toxicity, to renal functions and rheumatology are also included in this compilation. This book emphasizes that salicylates are polycompetent drugs that influence a large number and variety of biological processes. Their multifactorial actions, in relation to the known therapeutic and toxic effects are clearly described. This text likewise provides a refreshing multidisciplinary approach to aspirins that cover the whole extent from chemical to clinical aspects. This publication is a good reference for clinicians, pharmacists, and students intending to acquire general knowledge of the aspirin and salicylates.

Table of Contents


  • Abbreviations and Nomenclature

    1 History and Development of the Salicylates

    Early Use of Salicylate-Containing Plants

    Hippocratic Era

    Roman and Greek Medicine

    Asia and America

    European Middle Ages

    Nineteenth Century

    Chemical Developments

    Isolation and Purification of Salicylic Acid

    Synthesis and Commercial Development of Aspirin (Acetylsalicylic Acid)

    Other Salicylates

    2 Occurrence, Properties and Synthetic Developments of the Salicylates

    Naturally Occurring Salicylates

    Commercial Synthesis And Properties of The Salicylates

    Salicylic and Acetylsalicylic Acids, Their Salts and Esters

    Salicylamide

    Salicylate Derivatives

    Experimental Drugs

    3 Methylsalicylic Acid

    Aspirin Anhydride

    Dihydroxy- and Diacetoxybenzoic Acids

    Salicylazosulphapyridine (Sulphasalazine) and 5-Aminosalicyclic Acids

    Ester Pro-Drugs

    Other Sahcylate Derivatives

    Conclusions

    3 Absorption, Metabolism and Disposition of the Salicylates

    Introduction

    Absorption, Metabolism and Distribution

    Aspirin, Salicylate and Their Esters

    Analytical Methods

    Colorimetric and Spectrophotometric Procedures

    Spectrofluorimetry

    Thin-Layer Chromatography

    Gas-Liquid Chromatography

    High Pressure (Performance) Liquid Chromatography

    Determination of Glucuronides and Sulphate Metabolites

    4 Pharmacological and Biochemical Actions of the Salicylates

    Introduction

    Anti-Inflammatory Effects

    Studies in Animal Models

    Acute Inflammatory Models

    Actions of Salicylates in Acute Inflammatory Models

    Chronic Adjuvant Polyarthritis (Rats)

    Comparative Effects of Salicylates and Other NSAI Drugs in Adjuvant Arthritis

    Biochemical and Cellular Responses of Salicylates in Adjuvant Disease

    Actions of Salicylates in Other Chronic Models of Inflammation

    Biochemical Effects of Salicylates in Relation to Their Anti-Inflammatory Actions

    Analgesic Activity

    Introduction

    Anti-Pyresis

    5 Side-Effects and Toxicology of the Salicylates

    Introduction

    Gastrointestinal Side-Effects

    Historical

    Aspirin as a Major Cause of Bleeding and Ulceration

    Gastrointestinal Side-Effects from Salicylates in Arthritic Patients

    Assessment of Gastrointestinal Damage in Man

    Site and Pathology of Lesions

    Studies in Laboratory Animals

    Mechanisms of Gastric Mucosal Damage by Salicylates

    Summary

    Nephropathy

    Analgesic Abuse Syndrome

    Studies in Arthritic Patients

    Pathology

    Biochemical Effects of Salicylates

    Hepatotoxicity

    Clinical Evidence

    Pathology and Biochemical Changes

    Hypersensitivity Reactions and Asthma

    Aspirin-Sensitive Asthma

    Urticaria and Angioedema

    Teratogenesis and Pregnancy

    Miscellaneous Side-Effects

    Acute Salicylate Poisoning

    Toxic Manifestations

    Conclusions

    6 Therapeutic Uses of the Salicylates

    Introduction

    Arthritic Conditions

    Rheumatoid Arthritis

    Osteoarthritis (Osteoarthrosis)

    Miscellaneous

    Drug Monitoring

    Interactions with Other Anti-Inflammatory Drugs

    Analgesia

    Assessment of Pain

    Assessment of Pain

    Acute Surgery

    Postpartum and Episiotomy

    Dysmenorrhoea

    Cancer

    Anti-Pyresis

    Thromboembolic Conditions

    Perturbed Metabolic States

    Diabetes Melhtus

    Thyroiditis and Thyrotoxicosis

    Bartter's Syndrome

    Obesity

    Cystic Fibrosis

    Other Possible Uses

    Dermatological Conditions

    Diarrhea

    Ductus Arteriosus

    Sickle-Cell Anemia

    Thrombocytic Thrombocytopenic Purpura

    Anti-Tumor Activity

    Prevention of Allograft Rejection

    Anti-Viral and Anti-Parasitic Activities

    Multiple Sclerosis

    Miscellaneous

Product details

  • No. of pages: 358
  • Language: English
  • Copyright: © Butterworth-Heinemann 1984
  • Published: March 19, 1984
  • Imprint: Butterworth-Heinemann
  • eBook ISBN: 9781483191997

About the Author

K. D. Rainsford

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