Aspects of Pathogenesis

Aspects of Pathogenesis

1st Edition - January 1, 1974

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  • Editor: Gilbert Gottfried
  • eBook ISBN: 9780323156721

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Studies on the Development of Behavior and the Nervous System, Volume 2: Aspects of Neurogenesis describes the establishment of the connections between and within different parts of the nervous system. This book is organized into three sections encompassing eight chapters that specifically tackle the synaptogenesis, fetal function, and metamorphosis of the brain. The first four chapters of this book deal with a microscopic study of synapse formation, the specificity of interneuronal connections, and the development of excitatory and inhibitory synapses, especially in relation to early behavior. The following chapters examine the electrophysiological functioning of intact, living fetuses at macroscopic level. The concluding chapters look into the important events happening in the nervous system during metamorphosis and birth. These chapters also discuss the critical role of hormones and biochemical factors during these stages. This book is of great value to neurologists, developmental biologists, and researchers.

Table of Contents

  • List of Contributors


    Dedication to G. E. Coghill (1872-1941)

    Section 1 Synaptogenesis and the Problem of Neuronal Specificity: Structural and Functional Aspects


    Development of the Cerebral Neocortex of the Rat

    I. Introduction

    II. Histogenesis of the Cerebral Cortex

    III. Growth of Dendrites

    IV. Growth of Axons

    V. Synaptogenesis

    VI. Summary


    Tissue Culture Models of Developing Brain Functions

    I. Introduction

    II. Synaptogenesis in Embryonic CNS Cultures

    III. Development of Complex Organotypic Bioelectric Activities in Long-Term CNS Cultures

    IV. Spontaneous Patterned Discharges in CNS Explants as Model of Embryonic Motility

    V. Role of Inhibitory Systems in Masking Early "Behavioral Repertoire" of CNS Cultures and Embryos

    VI. Plasticity in Stereotyped "Self-Organizing" CNS Explants

    VII. Outlook


    Problems of Neuronal Specificity in the Development of Some Behavioral Patterns in Amphibia

    I. Introduction

    II. Corneal Specificity

    III. Cutaneous Local Sign Specificity

    IV. Myotypic Specificity

    V. Summary and Conclusions


    A Plentitude of Neurons

    I. Introduction

    II. Two Modes of Neuronal Ontogeny

    III. Constructive and Destructive Forms of Neuronal Plasticity

    IV. Neuronal Evolution in Relation to Ontogeny

    V. The Functions of Experience

    VI. Neuronal Modification by Selective Depletion

    VII. Nativism and Empiricism in the Light of the Theory of Neuronal Plenitude

    VIII. Summary


    Section 2 Fetal Brain Function: Sensory and Motor Aspects


    Early Epigenesis of Recipient Functions in the Neocortex

    I. Introduction

    II. Choice of Experimental Animal

    III. Surgical Preparation and Recording Technique

    IV. On the Properties of the Neocortex in Newborn Animals

    V. Results

    VI. Comments

    VII. Summary


    Entropy and Information in Fetal Behavior

    I. Introduction

    II. Development of Order in Fetal Behavior

    III. A Quantitative Entropy Model of the Fetal Brain

    IV. Dynamics of Fetal Behavior

    V. Conclusions


    Section 3 Metamorphosis and Birth: Hormonal and Physiological Aspects


    Endocrines, Neural Development, and Behavior

    I. Introduction

    II. The Anura

    III. Urodela

    IV. Mammals

    V. Summary


    The Significance of the Perinatal Period in the Neural and Behavioral Development of Precocial Mammals

    I. Introduction

    II. Subjects and Methods

    III. Results

    IV. Discussion

    V. Conclusion

    VI. Summary


    Author Index

    Subject Index

Product details

  • No. of pages: 304
  • Language: English
  • Copyright: © Academic Press 1974
  • Published: January 1, 1974
  • Imprint: Academic Press
  • eBook ISBN: 9780323156721

About the Editor

Gilbert Gottfried

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